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Ion channel regulation by the LKB1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level.

Evans AM, Peers C, Wyatt CN, Kumar P, Hardie DG.

Adv Exp Med Biol. 2012;758:81-90. doi: 10.1007/978-94-007-4584-1_11. Review.


AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.

Moral-Sanz J, Mahmoud AD, Ross FA, Eldstrom J, Fedida D, Hardie DG, Evans AM.

J Physiol. 2016 Sep 1;594(17):4901-15. doi: 10.1113/JP272032. Epub 2016 Jun 30.


AMP-activated protein kinase mediates carotid body excitation by hypoxia.

Wyatt CN, Mustard KJ, Pearson SA, Dallas ML, Atkinson L, Kumar P, Peers C, Hardie DG, Evans AM.

J Biol Chem. 2007 Mar 16;282(11):8092-8. Epub 2006 Dec 19.


Effects of modulators of AMP-activated protein kinase on TASK-1/3 and intracellular Ca(2+) concentration in rat carotid body glomus cells.

Kim D, Kang D, Martin EA, Kim I, Carroll JL.

Respir Physiol Neurobiol. 2014 May 1;195:19-26. doi: 10.1016/j.resp.2014.01.020. Epub 2014 Feb 13.


AMP-activated protein kinase and chemotransduction in the carotid body.

Wyatt CN, Evans AM.

Respir Physiol Neurobiol. 2007 Jul 1;157(1):22-9. Epub 2007 Mar 2. Review.


Ion channel regulation by AMPK: the route of hypoxia-response coupling in thecarotid body and pulmonary artery.

Evans AM, Hardie DG, Peers C, Wyatt CN, Viollet B, Kumar P, Dallas ML, Ross F, Ikematsu N, Jordan HL, Barr BL, Rafferty JN, Ogunbayo O.

Ann N Y Acad Sci. 2009 Oct;1177:89-100. doi: 10.1111/j.1749-6632.2009.05041.x.


AMP-activated protein kinase inhibits TREK channels.

Kréneisz O, Benoit JP, Bayliss DA, Mulkey DK.

J Physiol. 2009 Dec 15;587(Pt 24):5819-30. doi: 10.1113/jphysiol.2009.180372.


Translating blood-borne stimuli: chemotransduction in the carotid body.

Kumar P, Phil D.

Sheng Li Xue Bao. 2007 Apr 25;59(2):128-32. Review.


Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase.

Dallas ML, Scragg JL, Wyatt CN, Ross F, Hardie DG, Evans AM, Peers C.

Adv Exp Med Biol. 2009;648:57-63. doi: 10.1007/978-90-481-2259-2_6.


AMPK: a key regulator of energy balance in the single cell and the whole organism.

Hardie DG.

Int J Obes (Lond). 2008 Sep;32 Suppl 4:S7-12. doi: 10.1038/ijo.2008.116. Review.


Key roles for AMP-activated protein kinase in the function of the carotid body?

Wyatt CN, Pearson SA, Kumar P, Peers C, Hardie DG, Evans AM.

Adv Exp Med Biol. 2008;605:63-8.


AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells.

Evans AM, Hardie DG, Galione A, Peers C, Kumar P, Wyatt CN.

Novartis Found Symp. 2006;272:234-52; discussion 252-8, 274-9. Review.


Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase.

Ross FA, Rafferty JN, Dallas ML, Ogunbayo O, Ikematsu N, McClafferty H, Tian L, Widmer H, Rowe IC, Wyatt CN, Shipston MJ, Peers C, Hardie DG, Evans AM.

J Biol Chem. 2011 Apr 8;286(14):11929-36. doi: 10.1074/jbc.M110.189779. Epub 2011 Jan 5.


Modulation of the LKB1-AMPK Signalling Pathway Underpins Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.

Evans AM, Lewis SA, Ogunbayo OA, Moral-Sanz J.

Adv Exp Med Biol. 2015;860:89-99. doi: 10.1007/978-3-319-18440-1_11. Review.


Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.

Rajamohan F, Harris MS, Frisbie RK, Hoth LR, Geoghegan KF, Valentine JJ, Reyes AR, Landro JA, Qiu X, Kurumbail RG.

Protein Expr Purif. 2010 Oct;73(2):189-97. doi: 10.1016/j.pep.2010.04.022. Epub 2010 May 6.


Stress peptide PACAP engages multiple signaling pathways within the carotid body to initiate excitatory responses in respiratory and sympathetic chemosensory afferents.

Roy A, Derakhshan F, Wilson RJ.

Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15;304(12):R1070-84. doi: 10.1152/ajpregu.00465.2012. Epub 2013 Apr 17.


Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U, Neumann D, Schlattner U, Zou MH.

J Biol Chem. 2006 Mar 10;281(10):6366-75. Epub 2006 Jan 9.


Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?

Evans AM, Mustard KJ, Wyatt CN, Peers C, Dipp M, Kumar P, Kinnear NP, Hardie DG.

J Biol Chem. 2005 Dec 16;280(50):41504-11. Epub 2005 Sep 30. Erratum in: J Biol Chem. 2006 Jul 21;281(29):20660.


Carotid body chemosensory responses in mice deficient of TASK channels.

Ortega-Sáenz P, Levitsky KL, Marcos-Almaraz MT, Bonilla-Henao V, Pascual A, López-Barneo J.

J Gen Physiol. 2010 Apr;135(4):379-92. doi: 10.1085/jgp.200910302.


Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells.

Turner PJ, Buckler KJ.

J Physiol. 2013 Dec 1;591(23):5977-98. doi: 10.1113/jphysiol.2013.262022. Epub 2013 Sep 16.

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