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Influence of ivabradine on reverse remodelling during mechanical unloading.

Navaratnarajah M, Ibrahim M, Siedlecka U, van Doorn C, Shah A, Gandhi A, Dias P, Sarathchandra P, Yacoub MH, Terracciano CM.

Cardiovasc Res. 2013 Feb 1;97(2):230-9. doi: 10.1093/cvr/cvs318. Epub 2012 Oct 18.


Impact of combined clenbuterol and metoprolol therapy on reverse remodelling during mechanical unloading.

Navaratnarajah M, Siedlecka U, Ibrahim M, van Doorn C, Soppa G, Gandhi A, Shah A, Kukadia P, Yacoub MH, Terracciano CM.

PLoS One. 2014 Sep 30;9(9):e92909. doi: 10.1371/journal.pone.0092909. eCollection 2014.


Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure.

Soppa GK, Lee J, Stagg MA, Felkin LE, Barton PJ, Siedlecka U, Youssef S, Yacoub MH, Terracciano CM.

Cardiovasc Res. 2008 Mar 1;77(4):695-706. doi: 10.1093/cvr/cvm106. Epub 2008 Jan 4. Erratum in: Cardiovasc Res. 2008 Oct 1;80(1):159.


Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart.

Maczewski M, Mackiewicz U.

Cardiovasc Res. 2008 Jul 1;79(1):42-51. doi: 10.1093/cvr/cvn057. Epub 2008 Mar 1.


Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca(2+)-induced Ca(2+)release in a rodent model of heart failure.

Ibrahim M, Navaratnarajah M, Siedlecka U, Rao C, Dias P, Moshkov AV, Gorelik J, Yacoub MH, Terracciano CM.

Eur J Heart Fail. 2012 Jun;14(6):571-80. doi: 10.1093/eurjhf/hfs038. Epub 2012 Apr 1.


Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure.

Milliez P, Messaoudi S, Nehme J, Rodriguez C, Samuel JL, Delcayre C.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H435-41. doi: 10.1152/ajpheart.00591.2008. Epub 2008 Dec 12.


Effect of Chronic Heart Rate Reduction by I(f) Current Inhibitor Ivabradine on Left Ventricular Remodeling and Systolic Performance in Middle-Aged Rats With Postmyocardial Infarction Heart Failure.

Dedkov EI, Bogatyryov Y, McCooey DS, Christensen LP, Weiss RM, Tomanek RJ.

J Cardiovasc Pharmacol Ther. 2015 May;20(3):299-312. doi: 10.1177/1074248414553231. Epub 2014 Oct 5.


Heterotopic transplantation of the failing rat heart as a model of left ventricular mechanical unloading toward recovery.

Tsuneyoshi H, Oriyanhan W, Kanemitsu H, Shiina R, Nishina T, Ikeda T, Nishimura K, Komeda M.

ASAIO J. 2005 Jan-Feb;51(1):116-20.


Determination of optimal duration of mechanical unloading for failing hearts to achieve bridge to recovery in a rat heterotopic heart transplantation model.

Oriyanhan W, Tsuneyoshi H, Nishina T, Matsuoka S, Ikeda T, Komeda M.

J Heart Lung Transplant. 2007 Jan;26(1):16-23.


Myocardial atrophy and chronic mechanical unloading of the failing human heart: implications for cardiac assist device-induced myocardial recovery.

Diakos NA, Selzman CH, Sachse FB, Stehlik J, Kfoury AG, Wever-Pinzon O, Catino A, Alharethi R, Reid BB, Miller DV, Salama M, Zaitsev AV, Shibayama J, Li H, Fang JC, Li DY, Drakos SG.

J Am Coll Cardiol. 2014 Oct 14;64(15):1602-12. doi: 10.1016/j.jacc.2014.05.073.


Comparison of a beta-blocker and an If current inhibitor in rabbits with myocardial infarction.

Langenbach MR, Schmitz-Spanke S, Brockert M, Schepan M, Pomblum VJ, Gams E, Zirngibl H, Schipke JD.

J Cardiovasc Surg (Torino). 2006 Dec;47(6):719-25.


Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure.

Mulder P, Barbier S, Chagraoui A, Richard V, Henry JP, Lallemand F, Renet S, Lerebours G, Mahlberg-Gaudin F, Thuillez C.

Circulation. 2004 Apr 6;109(13):1674-9. Epub 2004 Feb 23.


Heterotopic abdominal heart transplantation in rats for functional studies of ventricular unloading.

Ibrahim M, Navaratnarajah M, Kukadia P, Rao C, Siedlecka U, Cartledge JE, Soppa GK, Van Doorn C, Yacoub MH, Terracciano CM.

J Surg Res. 2013 Jan;179(1):e31-9. doi: 10.1016/j.jss.2012.01.053. Epub 2012 Apr 1.


Heart rate reduction with ivabradine prevents thyroid hormone-induced cardiac remodeling in rat.

Kim BH, Cho KI, Kim SM, Kim N, Han J, Kim JY, Kim IJ.

Heart Vessels. 2013 Jul;28(4):524-35. doi: 10.1007/s00380-012-0304-z. Epub 2012 Nov 11.


Prolonged mechanical unloading reduces myofilament sensitivity to calcium and sarcoplasmic reticulum calcium uptake leading to contractile dysfunction.

Soppa GK, Lee J, Stagg MA, Siedlecka U, Youssef S, Yacoub MH, Terracciano CM.

J Heart Lung Transplant. 2008 Aug;27(8):882-9. doi: 10.1016/j.healun.2008.05.005. Epub 2008 Jun 25.


Long-term treatment with ivabradine in post-myocardial infarcted rats counteracts f-channel overexpression.

Suffredini S, Stillitano F, Comini L, Bouly M, Brogioni S, Ceconi C, Ferrari R, Mugelli A, Cerbai E.

Br J Pharmacol. 2012 Mar;165(5):1457-66. doi: 10.1111/j.1476-5381.2011.01627.x.


Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling.

Ceconi C, Comini L, Suffredini S, Stillitano F, Bouly M, Cerbai E, Mugelli A, Ferrari R.

Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H366-73. doi: 10.1152/ajpheart.01117.2009. Epub 2010 Oct 15.

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