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Items: 1 to 20 of 117

1.

Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells.

Kwon KC, Nityanandam R, New JS, Daniell H.

Plant Biotechnol J. 2013 Jan;11(1):77-86. doi: 10.1111/pbi.12008. Epub 2012 Oct 18.

2.

Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide.

Boyhan D, Daniell H.

Plant Biotechnol J. 2011 Jun;9(5):585-98. doi: 10.1111/j.1467-7652.2010.00582.x. Epub 2010 Dec 8.

3.

Low cost tuberculosis vaccine antigens in capsules: expression in chloroplasts, bio-encapsulation, stability and functional evaluation in vitro.

Lakshmi PS, Verma D, Yang X, Lloyd B, Daniell H.

PLoS One. 2013;8(1):e54708. doi: 10.1371/journal.pone.0054708. Epub 2013 Jan 23.

4.
5.

A fusion protein derived from plants holds promising potential as a new oral therapy for type 2 diabetes.

Choi J, Diao H, Feng ZC, Lau A, Wang R, Jevnikar AM, Ma S.

Plant Biotechnol J. 2014 May;12(4):425-35. doi: 10.1111/pbi.12149. Epub 2013 Dec 30.

6.
7.

A Cdk5 inhibitor enhances the induction of insulin secretion by exendin-4 both in vitro and in vivo.

Kitani K, Oguma S, Nishiki T, Ohmori I, Galons H, Matsui H, Meijer L, Tomizawa K.

J Physiol Sci. 2007 Aug;57(4):235-9. Epub 2007 Sep 15.

PMID:
17854513
8.

Oral delivery of Acid Alpha Glucosidase epitopes expressed in plant chloroplasts suppresses antibody formation in treatment of Pompe mice.

Su J, Sherman A, Doerfler PA, Byrne BJ, Herzog RW, Daniell H.

Plant Biotechnol J. 2015 Oct;13(8):1023-32. doi: 10.1111/pbi.12413. Epub 2015 Jun 5.

9.

Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents.

Arakawa M, Ebato C, Mita T, Hirose T, Kawamori R, Fujitani Y, Watada H.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):809-14. doi: 10.1016/j.bbrc.2009.10.054. Epub 2009 Oct 21.

PMID:
19836346
10.

Biological activity of AC3174, a peptide analog of exendin-4.

Hargrove DM, Kendall ES, Reynolds JM, Lwin AN, Herich JP, Smith PA, Gedulin BR, Flanagan SD, Jodka CM, Hoyt JA, McCowen KM, Parkes DG, Anderson CM.

Regul Pept. 2007 Jun 7;141(1-3):113-9. Epub 2007 Jan 11.

PMID:
17292977
11.
12.

The role of clusterin on pancreatic beta cell regeneration after exendin-4 treatment in neonatal streptozotocin administrated rats.

Kaya-Dagistanli F, Ozturk M.

Acta Histochem. 2013 Jul;115(6):577-86. doi: 10.1016/j.acthis.2012.12.007. Epub 2013 Jan 23.

PMID:
23351716
13.
14.

Effects of prolonged exendin-4 administration on entero-insular axis of normal and streptozotocin-induced diabetic rats.

Malendowicz LK, Macchi C, Nussdorfer GG, Nowak KW, Zyterska A, Ziolkowska A.

Int J Mol Med. 2003 Jun;11(6):763-6.

PMID:
12736719
15.

Pulmonary administered palmitic-acid modified exendin-4 peptide prolongs hypoglycemia in type 2 diabetic db/db mice.

Lee J, Lee C, Kim TH, Chi SC, Moon HR, Oh KT, Lee ES, Lee KC, Youn YS.

Regul Pept. 2012 Aug 20;177(1-3):68-72. doi: 10.1016/j.regpep.2012.04.010. Epub 2012 May 4.

PMID:
22561689
16.

Delivery of two-step transcription amplification exendin-4 plasmid system with arginine-grafted bioreducible polymer in type 2 diabetes animal model.

Kim PH, Lee M, Kim SW.

J Control Release. 2012 Aug 20;162(1):9-18. doi: 10.1016/j.jconrel.2012.06.010. Epub 2012 Jun 15.

17.

A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice.

Jin CH, Chae SY, Son S, Kim TH, Um KA, Youn YS, Lee S, Lee KC.

J Control Release. 2009 Feb 10;133(3):172-7. doi: 10.1016/j.jconrel.2008.09.091. Epub 2008 Oct 21.

PMID:
18977255
18.

Oral delivery of bioencapsulated proteins across blood-brain and blood-retinal barriers.

Kohli N, Westerveld DR, Ayache AC, Verma A, Shil P, Prasad T, Zhu P, Chan SL, Li Q, Daniell H.

Mol Ther. 2014 Mar;22(3):535-546. doi: 10.1038/mt.2013.273. Epub 2013 Dec 6.

19.

Novel glucagon-like peptide-1 analog delivered orally reduces postprandial glucose excursions in porcine and canine models.

Eldor R, Kidron M, Greenberg-Shushlav Y, Arbit E.

J Diabetes Sci Technol. 2010 Nov 1;4(6):1516-23.

20.

The GLP-1 mimetic exenatide potentiates insulin secretion in healthy cats.

Gilor C, Graves TK, Gilor S, Ridge TK, Rick M.

Domest Anim Endocrinol. 2011 Jul;41(1):42-9. doi: 10.1016/j.domaniend.2011.03.001. Epub 2011 Apr 6.

PMID:
21645806

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