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Items: 1 to 20 of 95

1.

Differential mitochondrial toxicity screening and multi-parametric data analysis.

Tsiper MV, Sturgis J, Avramova LV, Parakh S, Fatig R, Juan-García A, Li N, Rajwa B, Narayanan P, Qualls CW Jr, Robinson JP, Davisson VJ.

PLoS One. 2012;7(10):e45226. doi: 10.1371/journal.pone.0045226. Epub 2012 Oct 15.

2.

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.

O'Brien PJ, Irwin W, Diaz D, Howard-Cofield E, Krejsa CM, Slaughter MR, Gao B, Kaludercic N, Angeline A, Bernardi P, Brain P, Hougham C.

Arch Toxicol. 2006 Sep;80(9):580-604. Epub 2006 Apr 6.

PMID:
16598496
3.

A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells.

Li N, Oquendo E, Capaldi RA, Robinson JP, He YD, Hamadeh HK, Afshari CA, Lightfoot-Dunn R, Narayanan PK.

Toxicol Sci. 2014 Nov;142(1):261-73. doi: 10.1093/toxsci/kfu176. Epub 2014 Aug 27.

PMID:
25163676
4.

Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death.

Swiss R, Niles A, Cali JJ, Nadanaciva S, Will Y.

Toxicol In Vitro. 2013 Sep;27(6):1789-97. doi: 10.1016/j.tiv.2013.05.007. Epub 2013 May 29.

PMID:
23726864
5.
6.
7.

Boar spermatozoa successfully predict mitochondrial modes of toxicity: implications for drug toxicity testing and the 3R principles.

Vicente-Carrillo A, Edebert I, Garside H, Cotgreave I, Rigler R, Loitto V, Magnusson KE, Rodríguez-Martínez H.

Toxicol In Vitro. 2015 Apr;29(3):582-91. doi: 10.1016/j.tiv.2015.01.004. Epub 2015 Jan 23.

PMID:
25624015
8.

A combined in vitro approach to improve the prediction of mitochondrial toxicants.

Eakins J, Bauch C, Woodhouse H, Park B, Bevan S, Dilworth C, Walker P.

Toxicol In Vitro. 2016 Aug;34:161-70. doi: 10.1016/j.tiv.2016.03.016. Epub 2016 Apr 12.

9.

Mitochondrial biogenesis: pharmacological approaches.

Valero T.

Curr Pharm Des. 2014;20(35):5507-9.

PMID:
24606795
10.

Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.

EFSA GMO Panel Working Group on Animal Feeding Trials.

Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. doi: 10.1016/j.fct.2008.02.008. Epub 2008 Feb 13. Review.

PMID:
18328408
11.

The acute extracellular flux (XF) assay to assess compound effects on mitochondrial function.

Wang R, Novick SJ, Mangum JB, Queen K, Ferrick DA, Rogers GW, Stimmel JB.

J Biomol Screen. 2015 Mar;20(3):422-9. doi: 10.1177/1087057114557621. Epub 2014 Nov 7.

PMID:
25381255
12.

Assessment of mitochondrial toxicity in HepG2 cells cultured in high-glucose- or galactose-containing media.

Swiss R, Will Y.

Curr Protoc Toxicol. 2011 Aug;Chapter 2:Unit2.20. doi: 10.1002/0471140856.tx0220s49.

PMID:
21818751
13.

Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants.

Marroquin LD, Hynes J, Dykens JA, Jamieson JD, Will Y.

Toxicol Sci. 2007 Jun;97(2):539-47. Epub 2007 Mar 14.

PMID:
17361016
14.

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.

Kirkland D, Pfuhler S, Tweats D, Aardema M, Corvi R, Darroudi F, Elhajouji A, Glatt H, Hastwell P, Hayashi M, Kasper P, Kirchner S, Lynch A, Marzin D, Maurici D, Meunier JR, Müller L, Nohynek G, Parry J, Parry E, Thybaud V, Tice R, van Benthem J, Vanparys P, White P.

Mutat Res. 2007 Mar 30;628(1):31-55. Epub 2007 Jan 13.

PMID:
17293159
15.

Use of transgenic animals in understanding molecular mechanisms of toxicity.

Wolf CR, Henderson CJ.

J Pharm Pharmacol. 1998 Jun;50(6):567-74. Review.

PMID:
9680065
16.

Can drug safety be predicted and animal experiments reduced by using isolated mitochondrial fractions?

Pereira SP, Pereira GC, Moreno AJ, Oliveira PJ.

Altern Lab Anim. 2009 Sep;37(4):355-65. Review.

PMID:
19807208
17.

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.

Tolosa L, Gómez-Lechón MJ, Pérez-Cataldo G, Castell JV, Donato MT.

Arch Toxicol. 2013 Jun;87(6):1115-27. doi: 10.1007/s00204-013-1012-x. Epub 2013 Feb 9.

PMID:
23397584
18.

Computational systems biology and dose-response modeling in relation to new directions in toxicity testing.

Zhang Q, Bhattacharya S, Andersen ME, Conolly RB.

J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):253-76. doi: 10.1080/10937404.2010.483943.

PMID:
20574901
19.

Investigation of drug-induced mitochondrial toxicity using fluorescence-based oxygen-sensitive probes.

Hynes J, Marroquin LD, Ogurtsov VI, Christiansen KN, Stevens GJ, Papkovsky DB, Will Y.

Toxicol Sci. 2006 Jul;92(1):186-200. Epub 2006 Apr 25.

PMID:
16638925
20.

Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay.

McGowan EM, Alling N, Jackson EA, Yagoub D, Haass NK, Allen JD, Martinello-Wilks R.

PLoS One. 2011;6(6):e20623. doi: 10.1371/journal.pone.0020623. Epub 2011 Jun 3.

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