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Items: 1 to 20 of 97

1.

Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele.

Chen L, Faire M, Kissner MD, Laird DJ.

Hum Mol Genet. 2013 Jan 15;22(2):313-27. doi: 10.1093/hmg/dds430. Epub 2012 Oct 16.

2.

Discovery of N-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKIT Kinase.

Li B, Wang A, Liu J, Qi Z, Liu X, Yu K, Wu H, Chen C, Hu C, Wang W, Wu J, Hu Z, Ye L, Zou F, Liu F, Wang B, Wang L, Ren T, Zhang S, Bai M, Zhang S, Liu J, Liu Q.

J Med Chem. 2016 Sep 22;59(18):8456-72. doi: 10.1021/acs.jmedchem.6b00902. Epub 2016 Aug 30.

PMID:
27545040
3.

MicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation.

Kim WK, Park M, Kim YK, Tae YK, Yang HK, Lee JM, Kim H.

Clin Cancer Res. 2011 Dec 15;17(24):7584-94. doi: 10.1158/1078-0432.CCR-11-0166. Epub 2011 Oct 31.

4.

Low frequency of MAP kinase pathway alterations in KIT and PDGFRA wild-type GISTs.

Martinho O, Gouveia A, Viana-Pereira M, Silva P, Pimenta A, Reis RM, Lopes JM.

Histopathology. 2009 Jul;55(1):53-62. doi: 10.1111/j.1365-2559.2009.03323.x.

PMID:
19614767
5.

PDGFRA activating mutations in gastrointestinal stromal tumors.

Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA.

Science. 2003 Jan 31;299(5607):708-10. Epub 2003 Jan 9.

6.

High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors.

Hapkova I, Skarda J, Rouleau C, Thys A, Notarnicola C, Janikova M, Bernex F, Rypka M, Vanderwinden JM, Faure S, Vesely J, de Santa Barbara P.

Exp Mol Pathol. 2013 Apr;94(2):314-21. doi: 10.1016/j.yexmp.2012.12.004. Epub 2013 Jan 4.

PMID:
23295309
7.

The majority of early primordial germ cells acquire pluripotency by AKT activation.

Matsui Y, Takehara A, Tokitake Y, Ikeda M, Obara Y, Morita-Fujimura Y, Kimura T, Nakano T.

Development. 2014 Dec;141(23):4457-67. doi: 10.1242/dev.113779. Epub 2014 Oct 30.

8.

Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells.

Vincent JJ, Li Z, Lee SA, Liu X, Etter MO, Diaz-Perez SV, Taylor SK, Gkountela S, Lindgren AG, Clark AT.

PLoS One. 2011;6(12):e28960. doi: 10.1371/journal.pone.0028960. Epub 2011 Dec 15.

9.

Stem cell factor-mediated wild-type KIT receptor activation is critical for gastrointestinal stromal tumor cell growth.

Bai CG, Hou XW, Wang F, Qiu C, Zhu Y, Huang L, Zhao J, Xu JJ, Ma DL.

World J Gastroenterol. 2012 Jun 21;18(23):2929-37. doi: 10.3748/wjg.v18.i23.2929.

10.

Chemoattractant action and molecular signaling pathways of Kit ligand on mouse primordial germ cells.

Farini D, La Sala G, Tedesco M, De Felici M.

Dev Biol. 2007 Jun 15;306(2):572-83. Epub 2007 Mar 28.

11.
12.
13.

Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).

Duensing A, Medeiros F, McConarty B, Joseph NE, Panigrahy D, Singer S, Fletcher CD, Demetri GD, Fletcher JA.

Oncogene. 2004 May 13;23(22):3999-4006.

PMID:
15007386
14.

A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E.

Rubin BP, Antonescu CR, Scott-Browne JP, Comstock ML, Gu Y, Tanas MR, Ware CB, Woodell J.

Cancer Res. 2005 Aug 1;65(15):6631-9.

15.

Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer.

De Miguel MP, Cheng L, Holland EC, Federspiel MJ, Donovan PJ.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10458-63. Epub 2002 Jul 24.

16.

KIT receptor gain-of-function in hematopoiesis enhances stem cell self-renewal and promotes progenitor cell expansion.

Deshpande S, Bosbach B, Yozgat Y, Park CY, Moore MA, Besmer P.

Stem Cells. 2013 Aug;31(8):1683-95. doi: 10.1002/stem.1419.

17.

Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors.

Tarn C, Rink L, Merkel E, Flieder D, Pathak H, Koumbi D, Testa JR, Eisenberg B, von Mehren M, Godwin AK.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8387-92. doi: 10.1073/pnas.0803383105. Epub 2008 Jun 11.

18.

Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.

Noma K, Naomoto Y, Gunduz M, Matsuoka J, Yamatsuji T, Shirakawa Y, Nobuhisa T, Okawa T, Takaoka M, Tomono Y, Hiroyuki O, Gunduz E, Tanaka N.

Oncol Rep. 2005 Sep;14(3):645-50.

PMID:
16077968
19.

Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor.

Bosbach B, Deshpande S, Rossi F, Shieh JH, Sommer G, de Stanchina E, Veach DR, Scandura JM, Manova-Todorova K, Moore MA, Antonescu CR, Besmer P.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2276-83. doi: 10.1073/pnas.1115240109. Epub 2012 May 31.

20.

The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation.

Gkountela S, Li Z, Vincent JJ, Zhang KX, Chen A, Pellegrini M, Clark AT.

Nat Cell Biol. 2013 Jan;15(1):113-22. doi: 10.1038/ncb2638. Epub 2012 Dec 16.

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