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Items: 1 to 20 of 82

1.

Doxorubicin induces the DNA damage response in cultured human mesenchymal stem cells.

Cruet-Hennequart S, Prendergast ÁM, Shaw G, Barry FP, Carty MP.

Int J Hematol. 2012 Nov;96(5):649-56. doi: 10.1007/s12185-012-1196-5. Epub 2012 Oct 18.

PMID:
23076878
2.

Activation of DNA damage response pathways in human mesenchymal stem cells exposed to cisplatin or γ-irradiation.

Prendergast ÁM, Cruet-Hennequart S, Shaw G, Barry FP, Carty MP.

Cell Cycle. 2011 Nov 1;10(21):3768-77. doi: 10.4161/cc.10.21.17972. Epub 2011 Nov 1.

PMID:
22037398
3.

Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells.

Vera J, Raatz Y, Wolkenhauer O, Kottek T, Bhattacharya A, Simon JC, Kunz M.

Cell Signal. 2015 May;27(5):951-60. doi: 10.1016/j.cellsig.2015.01.020. Epub 2015 Feb 12.

PMID:
25683911
4.

Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1.

Sugimoto K, Sasaki M, Isobe Y, Tsutsui M, Suto H, Ando J, Tamayose K, Ando M, Oshimi K.

Oncogene. 2008 May 15;27(22):3091-101. Epub 2007 Dec 10.

PMID:
18071310
5.

Genotoxic effect of doxorubicin-transferrin conjugate on human leukemia cells.

Szwed M, Jozwiak Z.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Sep 1;771:53-63. doi: 10.1016/j.mrgentox.2014.06.007. Epub 2014 Jun 30.

PMID:
25308442
6.

Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics.

Ziegler V, Albers A, Fritz G.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1082-92. doi: 10.1016/j.bbamcr.2016.02.009. Epub 2016 Feb 12.

PMID:
26876155
7.

E2F1-dependent pathways are involved in amonafide analogue 7-d-induced DNA damage, G2/M arrest, and apoptosis in p53-deficient K562 cells.

Li Y, Shao J, Shen K, Xu Y, Liu J, Qian X.

J Cell Biochem. 2012 Oct;113(10):3165-77. doi: 10.1002/jcb.24194.

PMID:
22593008
8.

The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage.

Lee JH, Kang Y, Khare V, Jin ZY, Kang MY, Yoon Y, Hyun JW, Chung MH, Cho SI, Jun JY, Chang IY, You HJ.

Oncogene. 2010 Mar 11;29(10):1431-50. doi: 10.1038/onc.2009.438. Epub 2009 Dec 21.

PMID:
20023697
9.

[Mechanism of G2/M blockage triggered by activated-Chk1 in regulation of drug-resistance in K562/A02 cell line].

Wang HY, Zhang M, Zou P, You Y, Guo JM, Tang XQ, Zhao ZG, Wu YH.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Dec;14(6):1105-9. Chinese.

PMID:
17204173
10.

The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells.

Wang FZ, Fei HR, Cui YJ, Sun YK, Li ZM, Wang XY, Yang XY, Zhang JG, Sun BL.

Apoptosis. 2014 Sep;19(9):1389-98. doi: 10.1007/s10495-014-1010-3.

PMID:
24928205
11.

Persistent DNA damage-induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells.

Minieri V, Saviozzi S, Gambarotta G, Lo Iacono M, Accomasso L, Cibrario Rocchietti E, Gallina C, Turinetto V, Giachino C.

J Cell Mol Med. 2015 Apr;19(4):734-43. doi: 10.1111/jcmm.12387. Epub 2015 Jan 26.

12.

Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.

Lossaint G, Besnard E, Fisher D, Piette J, Dulić V.

Oncogene. 2011 Oct 13;30(41):4261-74. doi: 10.1038/onc.2011.135. Epub 2011 May 2.

PMID:
21532626
13.

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H.

J Biol Chem. 2003 Jun 13;278(24):21767-73. Epub 2003 Apr 3.

14.

Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma.

Ma J, Sun F, Li C, Zhang Y, Xiao W, Li Z, Pan Q, Zeng H, Xiao G, Yao K, Hong A, An J.

Cell Death Dis. 2014 Aug 14;5:e1377. doi: 10.1038/cddis.2014.293.

15.

Chk1, but not Chk2, is responsible for G2/M phase arrest induced by diallyl disulfide in human gastric cancer BGC823 cells.

Bo S, Hui H, Li W, Hui L, Hong X, Lin D, Dai WX, Wu YH, Ai XH, Hao J, Qi S.

Food Chem Toxicol. 2014 Jun;68:61-70. doi: 10.1016/j.fct.2014.03.007. Epub 2014 Mar 18.

PMID:
24650757
16.

Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.

King C, Diaz H, Barnard D, Barda D, Clawson D, Blosser W, Cox K, Guo S, Marshall M.

Invest New Drugs. 2014 Apr;32(2):213-26. doi: 10.1007/s10637-013-0036-7. Epub 2013 Oct 10.

PMID:
24114124
17.

Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways.

Ouyang G, Yao L, Ruan K, Song G, Mao Y, Bao S.

Cell Biol Int. 2009 Dec;33(12):1237-44. doi: 10.1016/j.cellbi.2009.08.011. Epub 2009 Sep 2.

PMID:
19732843
18.

Sterigmatocystin induces G1 arrest in primary human esophageal epithelial cells but induces G2 arrest in immortalized cells: key mechanistic differences in these two models.

Wang J, Huang S, Xing L, Cui J, Tian Z, Shen H, Jiang X, Yan X, Wang J, Zhang X.

Arch Toxicol. 2015 Nov;89(11):2015-25. doi: 10.1007/s00204-014-1362-z. Epub 2014 Oct 8.

PMID:
25294323
19.

A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation.

Xiao Z, Xue J, Sowin TJ, Rosenberg SH, Zhang H.

Oncogene. 2005 Feb 17;24(8):1403-11.

PMID:
15608676
20.

p73alpha regulates the sensitivity of bone marrow mesenchymal stem cells to DNA damage agents.

Liang W, Lu C, Li J, Yin JQ, Zhao RC.

Toxicology. 2010 Mar 30;270(1):49-56. doi: 10.1016/j.tox.2010.01.011. Epub 2010 Jan 25.

PMID:
20100536

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