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Items: 1 to 20 of 99

1.

Small molecules that target protein misfolding.

Gavrin LK, Denny RA, Saiah E.

J Med Chem. 2012 Dec 27;55(24):10823-43. doi: 10.1021/jm301182j. Epub 2012 Nov 1.

PMID:
23075044
2.

Recent developments in targeting protein misfolding diseases.

Denny RA, Gavrin LK, Saiah E.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):1935-44. doi: 10.1016/j.bmcl.2013.01.089. Epub 2013 Feb 4. Review.

3.

Pressure-temperature folding landscape in proteins involved in neurodegenerative diseases and cancer.

Cordeiro Y, Foguel D, Silva JL.

Biophys Chem. 2013 Dec 15;183:9-18. doi: 10.1016/j.bpc.2013.06.002. Epub 2013 Jun 14. Review.

4.

Protein-misfolding diseases and chaperone-based therapeutic approaches.

Chaudhuri TK, Paul S.

FEBS J. 2006 Apr;273(7):1331-49. Review.

5.

Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form.

Kerman A, Liu HN, Croul S, Bilbao J, Rogaeva E, Zinman L, Robertson J, Chakrabartty A.

Acta Neuropathol. 2010 Mar;119(3):335-44. doi: 10.1007/s00401-010-0646-5. Epub 2010 Jan 29.

PMID:
20111867
6.

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis.

Walker AK, Farg MA, Bye CR, McLean CA, Horne MK, Atkin JD.

Brain. 2010 Jan;133(Pt 1):105-16. doi: 10.1093/brain/awp267. Epub 2009 Nov 10.

PMID:
19903735
7.

Protein misfolding in disease and small molecule therapies.

Gomes CM.

Curr Top Med Chem. 2012;12(22):2460-9. Review.

PMID:
23339300
8.

Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.

Mulligan VK, Chakrabartty A.

Proteins. 2013 Aug;81(8):1285-303. doi: 10.1002/prot.24285. Epub 2013 Jul 2. Review.

PMID:
23508986
9.

Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency.

Nyon MP, Gooptu B.

Future Med Chem. 2014 Jun;6(9):1047-65. doi: 10.4155/fmc.14.58. Review.

PMID:
25068987
10.

[Can prion-like propagation occur in neurodegenerative diseases?: in view of transmissible systemic amyloidosis].

Yoshida K, Higuchi K, Ikeda S.

Brain Nerve. 2012 Jun;64(6):665-74. Review. Japanese.

PMID:
22647474
11.

Molecular pathways to polyglutamine aggregation.

Robertson AL, Bottomley SP.

Adv Exp Med Biol. 2012;769:115-24. Review.

PMID:
23560307
12.

Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review.

Khanam H, Ali A, Asif M, Shamsuzzaman.

Eur J Med Chem. 2016 Nov 29;124:1121-1141. doi: 10.1016/j.ejmech.2016.08.006. Epub 2016 Aug 6. Review.

PMID:
27597727
13.

Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.

Naeem A, Fazili NA.

Cell Biochem Biophys. 2011 Nov;61(2):237-50. doi: 10.1007/s12013-011-9200-x. Review.

PMID:
21573992
14.

Animal models for prion-like diseases.

Fernández-Borges N, Eraña H, Venegas V, Elezgarai SR, Harrathi C, Castilla J.

Virus Res. 2015 Sep 2;207:5-24. doi: 10.1016/j.virusres.2015.04.014. Epub 2015 Apr 20. Review.

PMID:
25907990
15.

Prediction of "hot spots" of aggregation in disease-linked polypeptides.

Sánchez de Groot N, Pallarés I, Avilés FX, Vendrell J, Ventura S.

BMC Struct Biol. 2005 Sep 30;5:18.

16.

Ligand binding and hydration in protein misfolding: insights from studies of prion and p53 tumor suppressor proteins.

Silva JL, Vieira TC, Gomes MP, Bom AP, Lima LM, Freitas MS, Ishimaru D, Cordeiro Y, Foguel D.

Acc Chem Res. 2010 Feb 16;43(2):271-9. doi: 10.1021/ar900179t. Review.

17.

Chemical kinetics for drug discovery to combat protein aggregation diseases.

Arosio P, Vendruscolo M, Dobson CM, Knowles TP.

Trends Pharmacol Sci. 2014 Mar;35(3):127-35. doi: 10.1016/j.tips.2013.12.005. Epub 2014 Feb 20. Review.

PMID:
24560688
18.

Prion, prionoids and infectious amyloid.

Liberski PP.

Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1:S80-4. doi: 10.1016/S1353-8020(13)70021-X. Review.

PMID:
24262195
19.

Pharmacological correction of misfolding of ABC proteins.

Rudashevskaya EL, Stockner T, Trauner M, Freissmuth M, Chiba P.

Drug Discov Today Technol. 2014 Jun;12:e87-94. doi: 10.1016/j.ddtec.2014.03.009. Review.

20.

Amyloidogenicity of p53: a hidden link between protein misfolding and cancer.

Gong H, Yang X, Zhao Y, Petersen RB, Liu X, Liu Y, Huang K.

Curr Protein Pept Sci. 2015;16(2):135-46. Review.

PMID:
25692950

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