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Lipopolysaccharide promotes lipid accumulation in human adventitial fibroblasts via TLR4-NF-κB pathway.

Wang J, Si Y, Wu C, Sun L, Ma Y, Ge A, Li B.

Lipids Health Dis. 2012 Oct 17;11:139. doi: 10.1186/1476-511X-11-139.


miR-21 attenuates lipopolysaccharide-induced lipid accumulation and inflammatory response: potential role in cerebrovascular disease.

Feng J, Li A, Deng J, Yang Y, Dang L, Ye Y, Li Y, Zhang W.

Lipids Health Dis. 2014 Feb 7;13:27. doi: 10.1186/1476-511X-13-27.


Pycnogenol attenuates atherosclerosis by regulating lipid metabolism through the TLR4-NF-κB pathway.

Luo H, Wang J, Qiao C, Ma N, Liu D, Zhang W.

Exp Mol Med. 2015 Oct 23;47:e191. doi: 10.1038/emm.2015.74.


Lipopolysaccharide activated TLR4/NF-κB signaling pathway of fibroblasts from uterine fibroids.

Guo J, Zheng L, Chen L, Luo N, Yang W, Qu X, Liu M, Cheng Z.

Int J Clin Exp Pathol. 2015 Sep 1;8(9):10014-25. eCollection 2015.


oxLDL/β2GPI/anti-β2GPI complex induced macrophage differentiation to foam cell involving TLR4/NF-kappa B signal transduction pathway.

Xu Y, Kong X, Zhou H, Zhang X, Liu J, Yan J, Xie H, Xie Y.

Thromb Res. 2014 Aug;134(2):384-92. doi: 10.1016/j.thromres.2014.05.017. Epub 2014 May 20.


Toll-like receptor 4 is involved in bacterial endotoxin-induced endothelial cell injury and SOC-mediated calcium regulation.

Sun R, Zhu Z, Su Q, Li T, Song Q.

Cell Biol Int. 2012 May 1;36(5):475-81. doi: 10.1042/CBI20110535.


Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells.

Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA.

Hepatology. 2003 May;37(5):1043-55.


Effects of hydroxysafflor yellow A on proliferation and collagen synthesis of rat vascular adventitial fibroblasts induced by angiotensin II.

Yuan W, Yang D, Sun X, Liu W, Wang L, Li X, Man X, Fu Q.

Int J Clin Exp Pathol. 2014 Aug 15;7(9):5772-81. eCollection 2014.


Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages.

Gu JQ, Ikuyama S, Wei P, Fan B, Oyama J, Inoguchi T, Nishimura J.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1390-400. doi: 10.1152/ajpendo.90543.2008. Epub 2008 Oct 14.


Statin pretreatment inhibits the lipopolysaccharide-induced epithelial-mesenchymal transition via the downregulation of toll-like receptor 4 and nuclear factor-κB in human biliary epithelial cells.

Kim Y, Lee EJ, Jang HK, Kim CH, Kim DG, Han JH, Park SM.

J Gastroenterol Hepatol. 2016 Jun;31(6):1220-8. doi: 10.1111/jgh.13230.


Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts.

Burke JP, Cunningham MF, Watson RW, Docherty NG, Coffey JC, O'Connell PR.

Br J Surg. 2010 Jul;97(7):1126-34. doi: 10.1002/bjs.7045.


The role of TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in neuroinflammation in hippocampal neurons.

Zhao M, Zhou A, Xu L, Zhang X.

Neuroscience. 2014 Jun 6;269:93-101. doi: 10.1016/j.neuroscience.2014.03.039. Epub 2014 Mar 27.


TLR4/NF-κB signaling contributes to chronic unpredictable mild stress-induced atherosclerosis in ApoE-/- mice.

Tang YL, Jiang JH, Wang S, Liu Z, Tang XQ, Peng J, Yang YZ, Gu HF.

PLoS One. 2015 Apr 10;10(4):e0123685. doi: 10.1371/journal.pone.0123685. eCollection 2015.


The effects of ox-LDL in human atherosclerosis may be mediated in part via the toll-like receptor 4 pathway.

Geng H, Wang A, Rong G, Zhu B, Deng Y, Chen J, Zhong R.

Mol Cell Biochem. 2010 Sep;342(1-2):201-6. doi: 10.1007/s11010-010-0484-8. Epub 2010 May 14.


Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-κB pathway.

Zhao W, Ma G, Chen X.

Vascul Pharmacol. 2014 Dec;63(3):162-72. doi: 10.1016/j.vph.2014.06.008. Epub 2014 Aug 16.


Oncostatin M and TLR-4 ligand synergize to induce MCP-1, IL-6, and VEGF in human aortic adventitial fibroblasts and smooth muscle cells.

Schnittker D, Kwofie K, Ashkar A, Trigatti B, Richards CD.

Mediators Inflamm. 2013;2013:317503. doi: 10.1155/2013/317503. Epub 2013 Nov 6.


Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages.

Feng X, Zhang Y, Xu R, Xie X, Tao L, Gao H, Gao Y, He Z, Wang H.

Atherosclerosis. 2010 Feb;208(2):396-405. doi: 10.1016/j.atherosclerosis.2009.07.035. Epub 2009 Jul 23.


Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes.

Guijarro-Muñoz I, Compte M, Álvarez-Cienfuegos A, Álvarez-Vallina L, Sanz L.

J Biol Chem. 2014 Jan 24;289(4):2457-68. doi: 10.1074/jbc.M113.521161. Epub 2013 Dec 4.


Tormentic acid inhibits LPS-induced inflammatory response in human gingival fibroblasts via inhibition of TLR4-mediated NF-κB and MAPK signalling pathway.

Jian CX, Li MZ, Zheng WY, He Y, Ren Y, Wu ZM, Fan QS, Hu YH, Li CJ.

Arch Oral Biol. 2015 Sep;60(9):1327-32. doi: 10.1016/j.archoralbio.2015.05.005. Epub 2015 May 22.


Atorvastatin suppresses LPS-induced rapid upregulation of Toll-like receptor 4 and its signaling pathway in endothelial cells.

Wang Y, Zhang MX, Meng X, Liu FQ, Yu GS, Zhang C, Sun T, Wang XP, Li L, Wang YY, Ding SF, Yang JM, Zhang Y.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1743-52. doi: 10.1152/ajpheart.01335.2008. Epub 2011 Feb 11.

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