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Items: 1 to 20 of 89

1.

Experimental and in silico modelling analyses of the gene expression pathway for recombinant antibody and by-product production in NS0 cell lines.

Mead EJ, Chiverton LM, Spurgeon SK, Martin EB, Montague GA, Smales CM, von der Haar T.

PLoS One. 2012;7(10):e47422. doi: 10.1371/journal.pone.0047422. Epub 2012 Oct 10.

2.

Functional proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate.

Dinnis DM, Stansfield SH, Schlatter S, Smales CM, Alete D, Birch JR, Racher AJ, Marshall CT, Nielsen LK, James DC.

Biotechnol Bioeng. 2006 Aug 5;94(5):830-41.

PMID:
16489627
3.

Derivation and characterization of cholesterol-independent non-GS NS0 cell lines for production of recombinant antibodies.

Hartman TE, Sar N, Genereux K, Barritt DS, He Y, Burky JE, Wesson MC, Tso JY, Tsurushita N, Zhou W, Sauer PW.

Biotechnol Bioeng. 2007 Feb 1;96(2):294-306.

PMID:
16897745
4.

Comparative proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate.

Smales CM, Dinnis DM, Stansfield SH, Alete D, Sage EA, Birch JR, Racher AJ, Marshall CT, James DC.

Biotechnol Bioeng. 2004 Nov 20;88(4):474-88.

PMID:
15459912
5.

Molecular analysis of successful cell line selection in transfected GS-NS0 myeloma cells.

Barnes LM, Bentley CM, Moy N, Dickson AJ.

Biotechnol Bioeng. 2007 Feb 1;96(2):337-48.

PMID:
17001634
6.

Dynamic analysis of GS-NS0 cells producing a recombinant monoclonal antibody during fed-batch culture.

Stansfield SH, Allen EE, Dinnis DM, Racher AJ, Birch JR, James DC.

Biotechnol Bioeng. 2007 Jun 1;97(2):410-24.

PMID:
17115445
7.

CHO cell line specific prediction and control of recombinant monoclonal antibody N-glycosylation.

Grainger RK, James DC.

Biotechnol Bioeng. 2013 Nov;110(11):2970-83. doi: 10.1002/bit.24959. Epub 2013 Jun 6.

PMID:
23737295
8.

Metabolic rates, growth phase, and mRNA levels influence cell-specific antibody production levels from in vitro-cultured mammalian cells at sub-physiological temperatures.

Marchant RJ, Al-Fageeh MB, Underhill MF, Racher AJ, Smales CM.

Mol Biotechnol. 2008 May;39(1):69-77. doi: 10.1007/s12033-008-9032-0. Epub 2008 Feb 6. Erratum in: Mol Biotechnol. 2011 Nov;49(3):277.

PMID:
18253867
9.

On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells.

Schlatter S, Stansfield SH, Dinnis DM, Racher AJ, Birch JR, James DC.

Biotechnol Prog. 2005 Jan-Feb;21(1):122-33.

PMID:
15903249
10.

Proteomic analysis of enriched microsomal fractions from GS-NS0 murine myeloma cells with varying secreted recombinant monoclonal antibody productivities.

Alete DE, Racher AJ, Birch JR, Stansfield SH, James DC, Smales CM.

Proteomics. 2005 Dec;5(18):4689-704.

PMID:
16247733
11.

Controlling trisulfide modification in recombinant monoclonal antibody produced in fed-batch cell culture.

Kshirsagar R, McElearney K, Gilbert A, Sinacore M, Ryll T.

Biotechnol Bioeng. 2012 Oct;109(10):2523-32. doi: 10.1002/bit.24511. Epub 2012 Apr 9.

PMID:
22473825
12.
13.

An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer.

McLeod J, O'Callaghan PM, Pybus LP, Wilkinson SJ, Root T, Racher AJ, James DC.

Biotechnol Bioeng. 2011 Sep;108(9):2193-204. doi: 10.1002/bit.23146. Epub 2011 Apr 27.

PMID:
21445882
14.
15.

Molecular definition of predictive indicators of stable protein expression in recombinant NS0 myeloma cells.

Barnes LM, Bentley CM, Dickson AJ.

Biotechnol Bioeng. 2004 Jan 20;85(2):115-21.

PMID:
14704993
16.

Cyclin and DNA distributed cell cycle model for GS-NS0 cells.

García Münzer DG, Kostoglou M, Georgiadis MC, Pistikopoulos EN, Mantalaris A.

PLoS Comput Biol. 2015 Feb 27;11(2):e1004062. doi: 10.1371/journal.pcbi.1004062. eCollection 2015 Feb.

17.

Proteins improving recombinant antibody production in mammalian cells.

Nishimiya D.

Appl Microbiol Biotechnol. 2014 Feb;98(3):1031-42. doi: 10.1007/s00253-013-5427-3. Epub 2013 Dec 11. Review.

PMID:
24327213
18.

Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells.

Hills AE, Patel A, Boyd P, James DC.

Biotechnol Bioeng. 2001 Oct 20;75(2):239-51.

PMID:
11536148
19.

Protein disulfide isomerase does not control recombinant IgG4 productivity in mammalian cell lines.

Hayes NV, Smales CM, Klappa P.

Biotechnol Bioeng. 2010 Mar 1;105(4):770-9. doi: 10.1002/bit.22587.

PMID:
19882737
20.

A global RNA-seq-driven analysis of CHO host and production cell lines reveals distinct differential expression patterns of genes contributing to recombinant antibody glycosylation.

Könitzer JD, Müller MM, Leparc G, Pauers M, Bechmann J, Schulz P, Schaub J, Enenkel B, Hildebrandt T, Hampel M, Tolstrup AB.

Biotechnol J. 2015 Sep;10(9):1412-23. doi: 10.1002/biot.201400652. Epub 2015 Aug 26.

PMID:
26212696

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