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Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement.

Lok BH, Powell SN.

Clin Cancer Res. 2012 Dec 1;18(23):6400-6. doi: 10.1158/1078-0432.CCR-11-3150. Epub 2012 Oct 15. Review.


Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.

Cramer-Morales K, Nieborowska-Skorska M, Scheibner K, Padget M, Irvine DA, Sliwinski T, Haas K, Lee J, Geng H, Roy D, Slupianek A, Rassool FV, Wasik MA, Childers W, Copland M, Müschen M, Civin CI, Skorski T.

Blood. 2013 Aug 15;122(7):1293-304. doi: 10.1182/blood-2013-05-501072. Epub 2013 Jul 8.


RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination.

Lok BH, Carley AC, Tchang B, Powell SN.

Oncogene. 2013 Jul 25;32(30):3552-8. doi: 10.1038/onc.2012.391. Epub 2012 Sep 10.


Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins.

Prakash R, Zhang Y, Feng W, Jasin M.

Cold Spring Harb Perspect Biol. 2015 Apr 1;7(4):a016600. doi: 10.1101/cshperspect.a016600. Review.


Dynamic regulatory interactions of rad51, rad52, and replication protein-a in recombination intermediates.

Sugiyama T, Kantake N.

J Mol Biol. 2009 Jul 3;390(1):45-55. doi: 10.1016/j.jmb.2009.05.009. Epub 2009 May 13.


Recovery of deficient homologous recombination in Brca2-depleted mouse cells by wild-type Rad51 expression.

Lee SA, Roques C, Magwood AC, Masson JY, Baker MD.

DNA Repair (Amst). 2009 Feb 1;8(2):170-81. doi: 10.1016/j.dnarep.2008.10.002. Epub 2008 Nov 18.


Therapeutic exploitation of tumor cell defects in homologous recombination.

Powell SN, Kachnic LA.

Anticancer Agents Med Chem. 2008 May;8(4):448-60. Review.


Effect of the expression of BRCA2 on spontaneous homologous recombination and DNA damage-induced nuclear foci in Saccharomyces cerevisiae.

Spugnesi L, Balia C, Collavoli A, Falaschi E, Quercioli V, Caligo MA, Galli A.

Mutagenesis. 2013 Mar;28(2):187-95. doi: 10.1093/mutage/ges069. Epub 2013 Jan 16.


Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.

Chandramouly G, McDevitt S, Sullivan K, Kent T, Luz A, Glickman JF, Andrake M, Skorski T, Pomerantz RT.

Chem Biol. 2015 Nov 19;22(11):1491-504. doi: 10.1016/j.chembiol.2015.10.003. Epub 2015 Nov 5.


Protein dynamics during presynaptic-complex assembly on individual single-stranded DNA molecules.

Gibb B, Ye LF, Kwon Y, Niu H, Sung P, Greene EC.

Nat Struct Mol Biol. 2014 Oct;21(10):893-900. doi: 10.1038/nsmb.2886. Epub 2014 Sep 7.


Rad51 protein controls Rad52-mediated DNA annealing.

Wu Y, Kantake N, Sugiyama T, Kowalczykowski SC.

J Biol Chem. 2008 May 23;283(21):14883-92. doi: 10.1074/jbc.M801097200. Epub 2008 Mar 12.


Functional analyses of the C-terminal half of the Saccharomyces cerevisiae Rad52 protein.

Kagawa W, Arai N, Ichikawa Y, Saito K, Sugiyama S, Saotome M, Shibata T, Kurumizaka H.

Nucleic Acids Res. 2014 Jan;42(2):941-51. doi: 10.1093/nar/gkt986. Epub 2013 Oct 25.


Vital roles of the second DNA-binding site of Rad52 protein in yeast homologous recombination.

Arai N, Kagawa W, Saito K, Shingu Y, Mikawa T, Kurumizaka H, Shibata T.

J Biol Chem. 2011 May 20;286(20):17607-17. doi: 10.1074/jbc.M110.216739. Epub 2011 Mar 28.


Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.

Huang F, Goyal N, Sullivan K, Hanamshet K, Patel M, Mazina OM, Wang CX, An WF, Spoonamore J, Metkar S, Emmitte KA, Cocklin S, Skorski T, Mazin AV.

Nucleic Acids Res. 2016 May 19;44(9):4189-99. doi: 10.1093/nar/gkw087. Epub 2016 Feb 11.


Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.

Chun J, Buechelmaier ES, Powell SN.

Mol Cell Biol. 2013 Jan;33(2):387-95. doi: 10.1128/MCB.00465-12. Epub 2012 Nov 12.


Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA capture.

Sugiyama T, Kantake N, Wu Y, Kowalczykowski SC.

EMBO J. 2006 Nov 29;25(23):5539-48. Epub 2006 Nov 9.


Rad52 promotes second-end DNA capture in double-stranded break repair to form complement-stabilized joint molecules.

Nimonkar AV, Sica RA, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3077-82. doi: 10.1073/pnas.0813247106. Epub 2009 Feb 9.


Role of the Rad52 amino-terminal DNA binding activity in DNA strand capture in homologous recombination.

Shi I, Hallwyl SC, Seong C, Mortensen U, Rothstein R, Sung P.

J Biol Chem. 2009 Nov 27;284(48):33275-84. doi: 10.1074/jbc.M109.057752. Epub 2009 Oct 6.


Rad52 inactivation is synthetically lethal with BRCA2 deficiency.

Feng Z, Scott SP, Bussen W, Sharma GG, Guo G, Pandita TK, Powell SN.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):686-91. doi: 10.1073/pnas.1010959107. Epub 2010 Dec 8.


Synergistic actions of Rad51 and Rad52 in recombination and DNA repair.

Benson FE, Baumann P, West SC.

Nature. 1998 Jan 22;391(6665):401-4.


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