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Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma.

He L, Yang X, Cao X, Liu F, Quan M, Cao J.

Oncol Rep. 2013 Jan;29(1):103-8. doi: 10.3892/or.2012.2076. Epub 2012 Oct 9.


Purified vitexin compound 1 inhibits growth and angiogenesis through activation of FOXO3a by inactivation of Akt in hepatocellular carcinoma.

Wang J, Zheng X, Zeng G, Zhou Y, Yuan H.

Int J Mol Med. 2014 Feb;33(2):441-8. doi: 10.3892/ijmm.2013.1587. Epub 2013 Dec 12.


Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma.

Wang JG, Zheng XX, Zeng GY, Zhou YJ, Yuan H.

Oncol Rep. 2014 Jan;31(1):488-96. doi: 10.3892/or.2013.2855. Epub 2013 Nov 15.


Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells.

Yang J, Yang Y, Tian L, Sheng XF, Liu F, Cao JG.

World J Gastroenterol. 2011 Oct 14;17(38):4298-307. doi: 10.3748/wjg.v17.i38.4298.


Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro.

Wu QF, Liu C, Tai MH, Liu D, Lei L, Wang RT, Tian M, Lü Y.

Acta Pharmacol Sin. 2010 Mar;31(3):361-6. doi: 10.1038/aps.2010.4. Epub 2010 Feb 15.


7-difluoromethoxyl-5,4'-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1.

Xiang HL, Liu F, Quan MF, Cao JG, Lv Y.

World J Gastroenterol. 2012 Sep 7;18(33):4618-26. doi: 10.3748/wjg.v18.i33.4618.


Arsenic trioxide-induced growth arrest of human hepatocellular carcinoma cells involving FOXO3a expression and localization.

Fei M, Lu M, Wang Y, Zhao Y, He S, Gao S, Ke Q, Liu Y, Li P, Cui X, Shen A, Cheng C.

Med Oncol. 2009;26(2):178-85. doi: 10.1007/s12032-008-9105-8. Epub 2008 Oct 21.


Apoptosis induced by 7-difluoromethoxyl-5,4'-di-n-octyl genistein via the inactivation of FoxM1 in ovarian cancer cells.

Ning Y, Li Q, Xiang H, Liu F, Cao J.

Oncol Rep. 2012 Jun;27(6):1857-64. doi: 10.3892/or.2012.1739. Epub 2012 Mar 22.


Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma.

Qu K, Xu X, Liu C, Wu Q, Wei J, Meng F, Zhou L, Wang Z, Lei L, Liu P.

Cancer Lett. 2013 Apr 30;331(1):105-14. doi: 10.1016/j.canlet.2012.12.008. Epub 2012 Dec 20.


[Effects of AG1478 on the expression of FOXM1 gene via FOXO3a in non-small cell lung cancer cells].

Gong XD, Yuan HH, Wang JY, Guo YH, Shi J, Jiang B.

Zhonghua Zhong Liu Za Zhi. 2013 Aug;35(8):572-8. Chinese.


Interferon-β gene-modified human bone marrow mesenchymal stem cells attenuate hepatocellular carcinoma through inhibiting AKT/FOXO3a pathway.

Xie C, Xie DY, Lin BL, Zhang GL, Wang PP, Peng L, Gao ZL.

Br J Cancer. 2013 Sep 3;109(5):1198-205. doi: 10.1038/bjc.2013.422. Epub 2013 Jul 25.


Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a.

Jiang L, Cao XC, Cao JG, Liu F, Quan MF, Sheng XF, Ren KQ.

Oncol Lett. 2013 May;5(5):1605-1610. Epub 2013 Mar 14.


Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating FOXO3a.

Xie C, Song LB, Wu JH, Li J, Yun JP, Lai JM, Xie DY, Lin BL, Yuan YF, Li M, Gao ZL.

PLoS One. 2012;7(7):e40607. doi: 10.1371/journal.pone.0040607. Epub 2012 Jul 16.


FOXO/TXNIP pathway is involved in the suppression of hepatocellular carcinoma growth by glutamate antagonist MK-801.

Yamaguchi F, Hirata Y, Akram H, Kamitori K, Dong Y, Sui L, Tokuda M.

BMC Cancer. 2013 Oct 10;13:468. doi: 10.1186/1471-2407-13-468.


Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells.

Yang LJ, Tang Q, Wu J, Chen Y, Zheng F, Dai Z, Hann SS.

J Exp Clin Cancer Res. 2016 Mar 31;35:59. doi: 10.1186/s13046-016-0330-2. Erratum in: J Exp Clin Cancer Res. 2016;35:81.


Serotonin promotes the proliferation of serum-deprived hepatocellular carcinoma cells via upregulation of FOXO3a.

Liang C, Chen W, Zhi X, Ma T, Xia X, Liu H, Zhang Q, Hu Q, Zhang Y, Bai X, Liang T.

Mol Cancer. 2013 Feb 19;12:14. doi: 10.1186/1476-4598-12-14.


T63, a new 4-arylidene curcumin analogue, induces cell cycle arrest and apoptosis through activation of the reactive oxygen species-FOXO3a pathway in lung cancer cells.

Liu H, Zhou BH, Qiu X, Wang HS, Zhang F, Fang R, Wang XF, Cai SH, Du J, Bu XZ.

Free Radic Biol Med. 2012 Dec 15;53(12):2204-17. doi: 10.1016/j.freeradbiomed.2012.10.537. Epub 2012 Oct 17.


LXRα-mediated downregulation of FOXM1 suppresses the proliferation of hepatocellular carcinoma cells.

Hu C, Liu D, Zhang Y, Lou G, Huang G, Chen B, Shen X, Gao M, Gong W, Zhou P, Dai S, Zeng Y, He F.

Oncogene. 2014 May 29;33(22):2888-97. doi: 10.1038/onc.2013.250. Epub 2013 Jul 1.


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