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p53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling.

Nayak G, Cooper GM.

Cell Death Dis. 2012 Oct 11;3:e400. doi: 10.1038/cddis.2012.138.


The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling.

Terragni J, Nayak G, Banerjee S, Medrano JL, Graham JR, Brennan JF, Sepulveda S, Cooper GM.

J Biol Chem. 2011 Oct 21;286(42):36215-27. doi: 10.1074/jbc.M111.246116. Epub 2011 Aug 26.


GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4.

Huo X, Liu S, Shao T, Hua H, Kong Q, Wang J, Luo T, Jiang Y.

J Biol Chem. 2014 Sep 5;289(36):24759-70. doi: 10.1074/jbc.M114.580738. Epub 2014 Jul 22.


Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53.

Charvet C, Wissler M, Brauns-Schubert P, Wang SJ, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U.

Mol Cell. 2011 Jun 10;42(5):584-96. doi: 10.1016/j.molcel.2011.03.033.


Inhibition of AKT/FoxO3a signaling induced PUMA expression in response to p53-independent cytotoxic effects of H1: A derivative of tetrandrine.

Zhang YX, Liu XM, Wang J, Li J, Liu Y, Zhang H, Yu XW, Wei N.

Cancer Biol Ther. 2015;16(6):965-75. doi: 10.1080/15384047.2015.1040950. Epub 2015 Apr 20.


Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ.

J Biol Chem. 2002 Dec 20;277(51):49676-84. Epub 2002 Oct 21.


Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells.

Li Y, Wang Z, Kong D, Li R, Sarkar SH, Sarkar FH.

J Biol Chem. 2008 Oct 10;283(41):27707-16. doi: 10.1074/jbc.M802759200. Epub 2008 Aug 7.


Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells.

Singh S, Ramamoorthy M, Vaughan C, Yeudall WA, Deb S, Palit Deb S.

Cell Death Differ. 2013 Apr;20(4):558-66. doi: 10.1038/cdd.2012.153. Epub 2012 Dec 14.


The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation.

Ambacher KK, Pitzul KB, Karajgikar M, Hamilton A, Ferguson SS, Cregan SP.

PLoS One. 2012;7(10):e46885. doi: 10.1371/journal.pone.0046885. Epub 2012 Oct 3.


miR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis.

Adlakha YK, Saini N.

Cell Death Dis. 2013 Mar 14;4:e542. doi: 10.1038/cddis.2013.46.


Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses.

Nair VD, Olanow CW.

J Biol Chem. 2008 May 30;283(22):15469-78. doi: 10.1074/jbc.M707238200. Epub 2008 Apr 3.


A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.

Hill R, Kalathur RK, Callejas S, Colaço L, Brandão R, Serelde B, Cebriá A, Blanco-Aparicio C, Pastor J, Futschik M, Dopazo A, Link W.

Breast Cancer Res. 2014 Dec 9;16(6):482. doi: 10.1186/s13058-014-0482-y.


Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3.

Allard D, Figg N, Bennett MR, Littlewood TD.

J Biol Chem. 2008 Jul 11;283(28):19739-47. doi: 10.1074/jbc.M710098200. Epub 2008 May 5.


Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1.

Zhang M, Zhang J, Chen X, Cho SJ, Chen X.

Genes Dev. 2013 Oct 15;27(20):2246-58. doi: 10.1101/gad.221739.113.


Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors.

Evans-Anderson HJ, Alfieri CM, Yutzey KE.

Circ Res. 2008 Mar 28;102(6):686-94. doi: 10.1161/CIRCRESAHA.107.163428. Epub 2008 Jan 24.


Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry.

Yeste-Velasco M, Folch J, Casadesús G, Smith MA, Pallàs M, Camins A.

Neuroscience. 2009 Mar 31;159(3):1135-47. doi: 10.1016/j.neuroscience.2009.01.035. Epub 2009 Jan 27.


Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway.

Shukla S, Bhaskaran N, Babcook MA, Fu P, Maclennan GT, Gupta S.

Carcinogenesis. 2014 Feb;35(2):452-60. doi: 10.1093/carcin/bgt316. Epub 2013 Sep 25.

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