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Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.

Coffey K, Blackburn TJ, Cook S, Golding BT, Griffin RJ, Hardcastle IR, Hewitt L, Huberman K, McNeill HV, Newell DR, Roche C, Ryan-Munden CA, Watson A, Robson CN.

PLoS One. 2012;7(10):e45539. doi: 10.1371/journal.pone.0045539. Epub 2012 Oct 8.


A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

Sun Y, Jiang X, Chen S, Fernandes N, Price BD.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13182-7. Epub 2005 Sep 2.


Regulation of TIP60 by ATF2 modulates ATM activation.

Bhoumik A, Singha N, O'Connell MJ, Ronai ZA.

J Biol Chem. 2008 Jun 20;283(25):17605-14. doi: 10.1074/jbc.M802030200. Epub 2008 Apr 8.


Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation.

Kobayashi J, Kato A, Ota Y, Ohba R, Komatsu K.

Mol Cancer. 2010 Feb 9;9:34. doi: 10.1186/1476-4598-9-34.


Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells.

Gong J, Zhu J, Goodman OB Jr, Pestell RG, Schlegel PN, Nanus DM, Shen R.

Oncogene. 2006 Mar 30;25(14):2011-21.


Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity.

Stimson L, Rowlands MG, Newbatt YM, Smith NF, Raynaud FI, Rogers P, Bavetsias V, Gorsuch S, Jarman M, Bannister A, Kouzarides T, McDonald E, Workman P, Aherne GW.

Mol Cancer Ther. 2005 Oct;4(10):1521-32.


Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation.

Sun Y, Jiang X, Chen S, Price BD.

FEBS Lett. 2006 Aug 7;580(18):4353-6. Epub 2006 Jul 10.


Tip60 in DNA damage response and growth control: many tricks in one HAT.

Squatrito M, Gorrini C, Amati B.

Trends Cell Biol. 2006 Sep;16(9):433-42. Epub 2006 Aug 9. Review.


KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.

Kaidi A, Jackson SP.

Nature. 2013 Jun 6;498(7452):70-4. doi: 10.1038/nature12201. Epub 2013 May 26.


Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.

Collins HM, Abdelghany MK, Messmer M, Yue B, Deeves SE, Kindle KB, Mantelingu K, Aslam A, Winkler GS, Kundu TK, Heery DM.

BMC Cancer. 2013 Jan 29;13:37. doi: 10.1186/1471-2407-13-37.


p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.

Eymin B, Claverie P, Salon C, Leduc C, Col E, Brambilla E, Khochbin S, Gazzeri S.

Mol Cell Biol. 2006 Jun;26(11):4339-50.


Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2.

Carlessi L, Buscemi G, Larson G, Hong Z, Wu JZ, Delia D.

Mol Cancer Ther. 2007 Mar;6(3):935-44.


A bivalent role of TIP60 histone acetyl transferase in human cancer.

Judes G, Rifaï K, Ngollo M, Daures M, Bignon YJ, Penault-Llorca F, Bernard-Gallon D.

Epigenomics. 2015;7(8):1351-63. doi: 10.2217/epi.15.76. Epub 2015 Dec 7. Review.


Rational design and validation of a Tip60 histone acetyltransferase inhibitor.

Gao C, Bourke E, Scobie M, Famme MA, Koolmeister T, Helleday T, Eriksson LA, Lowndes NF, Brown JA.

Sci Rep. 2014 Jun 20;4:5372. doi: 10.1038/srep05372.


The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.

Jiang X, Sun Y, Chen S, Roy K, Price BD.

J Biol Chem. 2006 Jun 9;281(23):15741-6. Epub 2006 Apr 9.


MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

Sharma GG, So S, Gupta A, Kumar R, Cayrou C, Avvakumov N, Bhadra U, Pandita RK, Porteus MH, Chen DJ, Cote J, Pandita TK.

Mol Cell Biol. 2010 Jul;30(14):3582-95. doi: 10.1128/MCB.01476-09. Epub 2010 May 17.


ING5 is a Tip60 cofactor that acetylates p53 in response to DNA damage.

Liu N, Wang J, Wang J, Wang R, Liu Z, Yu Y, Lu H.

Cancer Res. 2013 Jun 15;73(12):3749-60. doi: 10.1158/0008-5472.CAN-12-3684. Epub 2013 Apr 10.


Targeting cancer using KAT inhibitors to mimic lethal knockouts.

Brown JA, Bourke E, Eriksson LA, Kerin MJ.

Biochem Soc Trans. 2016 Aug 15;44(4):979-86. doi: 10.1042/BST20160081. Review.

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