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FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model.

Deuschle U, Schüler J, Schulz A, Schlüter T, Kinzel O, Abel U, Kremoser C.

PLoS One. 2012;7(10):e43044. doi: 10.1371/journal.pone.0043044. Epub 2012 Oct 9.


Regulation of N-Myc downstream regulated gene 2 by bile acids.

Langhi C, Pedraz-Cuesta E, Donate Y, Marrero PF, Haro D, Rodríguez JC.

Biochem Biophys Res Commun. 2013 Apr 26;434(1):102-9. doi: 10.1016/j.bbrc.2013.03.058. Epub 2013 Mar 27.


FXR induces SOCS3 and suppresses hepatocellular carcinoma.

Guo F, Xu Z, Zhang Y, Jiang P, Huang G, Chen S, Lyu X, Zheng P, Zhao X, Zeng Y, Wang S, He F.

Oncotarget. 2015 Oct 27;6(33):34606-16. doi: 10.18632/oncotarget.5314.


Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells.

He J, Zhao K, Zheng L, Xu Z, Gong W, Chen S, Shen X, Huang G, Gao M, Zeng Y, Zhang Y, He F.

Mol Cancer. 2015 Aug 25;14:163. doi: 10.1186/s12943-015-0427-9.


Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding.

Li G, Thomas AM, Williams JA, Kong B, Liu J, Inaba Y, Xie W, Guo GL.

PLoS One. 2012;7(4):e35895. doi: 10.1371/journal.pone.0035895. Epub 2012 Apr 23.


The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.

Deuschle U, Birkel M, Hambruch E, Hornberger M, Kinzel O, Perović-Ottstadt S, Schulz A, Hahn U, Burnet M, Kremoser C.

Int J Cancer. 2015 Jun 1;136(11):2693-704. doi: 10.1002/ijc.29312. Epub 2014 Nov 13.


Inhibition of Leydig tumor growth by farnesoid X receptor activation: the in vitro and in vivo basis for a novel therapeutic strategy.

Catalano S, Panza S, Malivindi R, Giordano C, Barone I, Bossi G, Lanzino M, Sirianni R, Mauro L, Sisci D, Bonofiglio D, Andò S.

Int J Cancer. 2013 May 15;132(10):2237-47. doi: 10.1002/ijc.27915. Epub 2012 Nov 7.


Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression.

Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, Forman BM, Xu Z, Xu R, Huang W.

Mol Endocrinol. 2012 May;26(5):775-85. doi: 10.1210/me.2011-1383. Epub 2012 Apr 2.


Functional and clinical evidence for NDRG2 as a candidate suppressor of liver cancer metastasis.

Lee DC, Kang YK, Kim WH, Jang YJ, Kim DJ, Park IY, Sohn BH, Sohn HA, Lee HG, Lim JS, Kim JW, Song EY, Kim DM, Lee MN, Oh GT, Kim SJ, Park KC, Yoo HS, Choi JY, Yeom YI.

Cancer Res. 2008 Jun 1;68(11):4210-20. doi: 10.1158/0008-5472.CAN-07-5040.


Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3.

Wang YD, Chen WD, Li C, Guo C, Li Y, Qi H, Shen H, Kong J, Long X, Yuan F, Wang X, Huang W.

Mol Endocrinol. 2015 Feb;29(2):322-31. doi: 10.1210/me.2014-1225. Epub 2014 Dec 12.


The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2.

Tarling EJ, Ahn H, de Aguiar Vallim TQ.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):787-95. doi: 10.1161/ATVBAHA.114.304179. Epub 2015 Jan 15.


The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway.

Wang J, Yin D, Xie C, Zheng T, Liang Y, Hong X, Lu Z, Song X, Song R, Yang H, Sun B, Bhatta N, Meng X, Pan S, Jiang H, Liu L.

Oncotarget. 2014 Sep 30;5(18):8478-91.


Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice.

Li G, Kong B, Zhu Y, Zhan L, Williams JA, Tawfik O, Kassel KM, Luyendyk JP, Wang L, Guo GL.

Toxicol Appl Pharmacol. 2013 Oct 15;272(2):299-305. doi: 10.1016/j.taap.2013.06.016. Epub 2013 Jun 26.


N-myc downstream-regulated gene 2 expression is associated with glucose transport and correlated with prognosis in breast carcinoma.

Ma J, Liu W, Guo H, Li S, Cao W, Du X, Lei S, Hou W, Xiong L, Yao L, Li N, Li Y.

Breast Cancer Res. 2014 Mar 18;16(2):R27. doi: 10.1186/bcr3628.


Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2.

Li D, Mei H, Pu J, Xiang X, Zhao X, Qu H, Huang K, Zheng L, Tong Q.

Mol Cancer. 2015 Feb 21;14:47. doi: 10.1186/s12943-015-0320-6.


Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064.

Martínez-Fernández P, Hierro L, Jara P, Alvarez L.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1119-29. doi: 10.1152/ajpgi.90371.2008. Epub 2009 Feb 19.


Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.

Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B.

Mol Endocrinol. 2003 Feb;17(2):259-72.


Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells.

Song Y, Pan G, Chen L, Ma S, Zeng T, Man Chan TH, Li L, Lian Q, Chow R, Cai X, Li Y, Li Y, Liu M, Li Y, Zhu Y, Wong N, Yuan YF, Pei D, Guan XY.

Gastroenterology. 2015 Oct;149(4):1068-81.e5. doi: 10.1053/j.gastro.2015.06.010. Epub 2015 Jun 20.


Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.

Catalano S, Malivindi R, Giordano C, Gu G, Panza S, Bonofiglio D, Lanzino M, Sisci D, Panno ML, Andò S.

J Biol Chem. 2010 Feb 19;285(8):5581-93. doi: 10.1074/jbc.M109.052670. Epub 2009 Dec 21.


Overexpression of N-Myc downstream-regulated gene 2 (NDRG2) regulates the proliferation and invasion of bladder cancer cells in vitro and in vivo.

Li R, Yu C, Jiang F, Gao L, Li J, Wang Y, Beckwith N, Yao L, Zhang J, Wu G.

PLoS One. 2013 Oct 16;8(10):e76689. doi: 10.1371/journal.pone.0076689. eCollection 2013.

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