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Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.

Murail S, Howard RJ, Broemstrup T, Bertaccini EJ, Harris RA, Trudell JR, Lindahl E.

PLoS Comput Biol. 2012;8(10):e1002710. doi: 10.1371/journal.pcbi.1002710. Epub 2012 Oct 4.


Structural basis for alcohol modulation of a pentameric ligand-gated ion channel.

Howard RJ, Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12149-54. doi: 10.1073/pnas.1104480108. Epub 2011 Jul 5.


Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.

Olsen RW, Li GD, Wallner M, Trudell JR, Bertaccini EJ, Lindahl E, Miller KW, Alkana RL, Davies DL.

Alcohol Clin Exp Res. 2014 Mar;38(3):595-603. doi: 10.1111/acer.12283. Epub 2013 Oct 24. Review.


Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.

Murail S, Wallner B, Trudell JR, Bertaccini E, Lindahl E.

Biophys J. 2011 Apr 6;100(7):1642-50. doi: 10.1016/j.bpj.2011.02.032.


X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.

Althoff T, Hibbs RE, Banerjee S, Gouaux E.

Nature. 2014 Aug 21;512(7514):333-7. doi: 10.1038/nature13669.


Structural insights into Cys-loop receptor function and ligand recognition.

Nys M, Kesters D, Ulens C.

Biochem Pharmacol. 2013 Oct 15;86(8):1042-53. doi: 10.1016/j.bcp.2013.07.001. Epub 2013 Jul 10. Review.


Reversal of ion-charge selectivity renders the pentameric ligand-gated ion channel GLIC insensitive to anaesthetics.

Tillman T, Cheng MH, Chen Q, Tang P, Xu Y.

Biochem J. 2013 Jan 1;449(1):61-8. doi: 10.1042/BJ20121072.


Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.

Nys M, Wijckmans E, Farinha A, Yoluk Ö, Andersson M, Brams M, Spurny R, Peigneur S, Tytgat J, Lindahl E, Ulens C.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6696-E6703. Epub 2016 Oct 10.


Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.

Horani S, Stater EP, Corringer PJ, Trudell JR, Harris RA, Howard RJ.

Alcohol Clin Exp Res. 2015 Jun;39(6):962-8. doi: 10.1111/acer.12735. Epub 2015 May 14.


General anesthetics predicted to block the GLIC pore with micromolar affinity.

LeBard DN, Hénin J, Eckenhoff RG, Klein ML, Brannigan G.

PLoS Comput Biol. 2012 May;8(5):e1002532. doi: 10.1371/journal.pcbi.1002532. Epub 2012 May 31.


Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.

Perkins DI, Trudell JR, Crawford DK, Asatryan L, Alkana RL, Davies DL.

J Biol Chem. 2009 Oct 2;284(40):27304-14. doi: 10.1074/jbc.M109.023598. Epub 2009 Aug 5.


Characterization of cys-loop receptor genes involved in inhibitory amine neurotransmission in parasitic and free living nematodes.

Beech RN, Callanan MK, Rao VT, Dawe GB, Forrester SG.

Parasitol Int. 2013 Dec;62(6):599-605. doi: 10.1016/j.parint.2013.03.010. Epub 2013 Apr 16.


Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR.

Chasapis CT, Argyriou AI, Corringer PJ, Bentrop D, Spyroulias GA.

Biochemistry. 2011 Nov 15;50(45):9681-3. doi: 10.1021/bi201223u. Epub 2011 Oct 20.


Anesthetic binding in a pentameric ligand-gated ion channel: GLIC.

Chen Q, Cheng MH, Xu Y, Tang P.

Biophys J. 2010 Sep 22;99(6):1801-9. doi: 10.1016/j.bpj.2010.07.023.


Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.

Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ.

J Neurochem. 2016 Jul;138(2):243-53. doi: 10.1111/jnc.13644. Epub 2016 May 25.


Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.

Forman SA, Miller KW.

Can J Anaesth. 2011 Feb;58(2):191-205. doi: 10.1007/s12630-010-9419-9. Epub 2011 Jan 7. Review.


Probing residues in the pore-forming (M2) domain of the Cys-loop receptor homologue GLIC reveals some unusual features.

Alqazzaz MA, Lummis SC.

Mol Membr Biol. 2015;32(1):26-31. doi: 10.3109/09687688.2015.1023377. Epub 2015 Apr 13.


Functional evaluation of key interactions evident in the structure of the eukaryotic Cys-loop receptor GluCl.

Daeffler KN, Lester HA, Dougherty DA.

ACS Chem Biol. 2014 Oct 17;9(10):2283-90. doi: 10.1021/cb500323d. Epub 2014 Aug 5.


Signal transduction pathways in the pentameric ligand-gated ion channels.

Mowrey D, Chen Q, Liang Y, Liang J, Xu Y, Tang P.

PLoS One. 2013 May 8;8(5):e64326. doi: 10.1371/journal.pone.0064326. Print 2013.

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