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Regulation of hepatic phase II metabolism in pregnant mice.

Wen X, Donepudi AC, Thomas PE, Slitt AL, King RS, Aleksunes LM.

J Pharmacol Exp Ther. 2013 Jan;344(1):244-52. doi: 10.1124/jpet.112.199034. Epub 2012 Oct 10.


Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARĪ±-, and Nrf2-null mice.

Aleksunes LM, Klaassen CD.

Drug Metab Dispos. 2012 Jul;40(7):1366-79. doi: 10.1124/dmd.112.045112. Epub 2012 Apr 11.


Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease.

Hardwick RN, Ferreira DW, More VR, Lake AD, Lu Z, Manautou JE, Slitt AL, Cherrington NJ.

Drug Metab Dispos. 2013 Mar;41(3):554-61. doi: 10.1124/dmd.112.048439. Epub 2012 Dec 7.


UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.

Xu J, Kulkarni SR, Li L, Slitt AL.

Drug Metab Dispos. 2012 Feb;40(2):259-66. doi: 10.1124/dmd.111.039925. Epub 2011 Oct 26.


The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure.

Court MH, Freytsis M, Wang X, Peter I, Guillemette C, Hazarika S, Duan SX, Greenblatt DJ, Lee WM; Acute Liver Failure Study Group.

J Pharmacol Exp Ther. 2013 May;345(2):297-307. doi: 10.1124/jpet.112.202010. Epub 2013 Feb 13.


Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy.

Aleksunes LM, Yeager RL, Wen X, Cui JY, Klaassen CD.

Toxicol Sci. 2012 Dec;130(2):257-68. doi: 10.1093/toxsci/kfs248. Epub 2012 Aug 17.


RNA-sequencing quantification of hepatic ontogeny and tissue distribution of mRNAs of phase II enzymes in mice.

Lu H, Gunewardena S, Cui JY, Yoo B, Zhong XB, Klaassen CD.

Drug Metab Dispos. 2013 Apr;41(4):844-57. doi: 10.1124/dmd.112.050211. Epub 2013 Feb 4.


Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.

Brand W, Boersma MG, Bik H, Hoek-van den Hil EF, Vervoort J, Barron D, Meinl W, Glatt H, Williamson G, van Bladeren PJ, Rietjens IM.

Drug Metab Dispos. 2010 Apr;38(4):617-25. doi: 10.1124/dmd.109.031047. Epub 2010 Jan 7.


Simultaneous determination of sulfation and glucuronidation of flavones in FVB mouse intestine in vitro and in vivo.

Fan Y, Tang L, Zhou J, Feng Q, Xia B, Liu Z.

J Appl Toxicol. 2013 Apr;33(4):273-80. doi: 10.1002/jat.1737. Epub 2011 Dec 15.


Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis.

Wu B, Basu S, Meng S, Wang X, Hu M.

Curr Drug Metab. 2011 Nov;12(9):900-16. Review.


Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice.

Fu ZD, Klaassen CD.

Toxicol Appl Pharmacol. 2014 Jan 1;274(1):137-46. doi: 10.1016/j.taap.2013.11.003. Epub 2013 Nov 13.


In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans.

Wong CC, Meinl W, Glatt HR, Barron D, Stalmach A, Steiling H, Crozier A, Williamson G.

J Nutr Biochem. 2010 Nov;21(11):1060-8. doi: 10.1016/j.jnutbio.2009.09.001. Epub 2009 Dec 1.


Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometry.

Doerge DR, Chang HC, Churchwell MI, Holder CL.

Drug Metab Dispos. 2000 Mar;28(3):298-307.


Glucuronidation and sulfation of 7-hydroxycoumarin in liver matrices from human, dog, monkey, rat, and mouse.

Wang Q, Jia R, Ye C, Garcia M, Li J, Hidalgo IJ.

In Vitro Cell Dev Biol Anim. 2005 Mar-Apr;41(3-4):97-103.


Tissue distribution and ontogeny of sulfotransferase enzymes in mice.

Alnouti Y, Klaassen CD.

Toxicol Sci. 2006 Oct;93(2):242-55. Epub 2006 Jun 28.


Regulation of Drug Disposition Gene Expression in Pregnant Mice with Car Receptor Activation.

Bright AS, Herrera-Garcia G, Moscovitz JE, You D, Guo GL, Aleksunes LM.

Nucl Receptor Res. 2016;3. pii: 101193.


Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells.

Westerink WM, Schoonen WG.

Toxicol In Vitro. 2007 Dec;21(8):1592-602. Epub 2007 Jul 18.


Modulation of metabolizing enzymes by bisphenol a in human and animal models.

Quesnot N, Bucher S, Fromenty B, Robin MA.

Chem Res Toxicol. 2014 Sep 15;27(9):1463-73. doi: 10.1021/tx500087p. Epub 2014 Aug 29. Review.


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