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Detection of methylated SEPT9 in plasma is a reliable screening method for both left- and right-sided colon cancers.

Tóth K, Sipos F, Kalmár A, Patai AV, Wichmann B, Stoehr R, Golcher H, Schellerer V, Tulassay Z, Molnár B.

PLoS One. 2012;7(9):e46000. doi: 10.1371/journal.pone.0046000. Epub 2012 Sep 25.


Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer.

Warren JD, Xiong W, Bunker AM, Vaughn CP, Furtado LV, Roberts WL, Fang JC, Samowitz WS, Heichman KA.

BMC Med. 2011 Dec 14;9:133. doi: 10.1186/1741-7015-9-133.


Validation of a real-time PCR-based qualitative assay for the detection of methylated SEPT9 DNA in human plasma.

Potter NT, Hurban P, White MN, Whitlock KD, Lofton-Day CE, Tetzner R, Koenig T, Quigley NB, Weiss G.

Clin Chem. 2014 Sep;60(9):1183-91. doi: 10.1373/clinchem.2013.221044. Epub 2014 Jun 17.


Detection of methylated septin 9 in tissue and plasma of colorectal patients with neoplasia and the relationship to the amount of circulating cell-free DNA.

Tóth K, Wasserkort R, Sipos F, Kalmár A, Wichmann B, Leiszter K, Valcz G, Juhász M, Miheller P, Patai ÁV, Tulassay Z, Molnár B.

PLoS One. 2014 Dec 19;9(12):e115415. doi: 10.1371/journal.pone.0115415. eCollection 2014.


Performance of a second-generation methylated SEPT9 test in detecting colorectal neoplasm.

Jin P, Kang Q, Wang X, Yang L, Yu Y, Li N, He YQ, Han X, Hang J, Zhang J, Song L, Han Y, Sheng JQ.

J Gastroenterol Hepatol. 2015 May;30(5):830-3. doi: 10.1111/jgh.12855.


Performance of the colorectal cancer screening marker Sept9 is influenced by age, diabetes and arthritis: a nested case-control study.

Ørntoft MB, Nielsen HJ, Ørntoft TF, Andersen CL; Danish Study Group on Early Detection of Colorectal Cancer.

BMC Cancer. 2015 Oct 29;15:819. doi: 10.1186/s12885-015-1832-6.


Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer.

Church TR, Wandell M, Lofton-Day C, Mongin SJ, Burger M, Payne SR, Castaños-Vélez E, Blumenstein BA, Rösch T, Osborn N, Snover D, Day RW, Ransohoff DF; PRESEPT Clinical Study Steering Committee, Investigators and Study Team.

Gut. 2014 Feb;63(2):317-25. doi: 10.1136/gutjnl-2012-304149. Epub 2013 Feb 13.


Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay.

Grützmann R, Molnar B, Pilarsky C, Habermann JK, Schlag PM, Saeger HD, Miehlke S, Stolz T, Model F, Roblick UJ, Bruch HP, Koch R, Liebenberg V, Devos T, Song X, Day RH, Sledziewski AZ, Lofton-Day C.

PLoS One. 2008;3(11):e3759. doi: 10.1371/journal.pone.0003759. Epub 2008 Nov 19.


Detection of Colorectal Cancer Using a Simplified SEPT9 Gene Methylation Assay Is a Reliable Method for Opportunistic Screening.

Wu D, Zhou G, Jin P, Zhu J, Li S, Wu Q, Wang G, Sheng J, Wang J, Song L, Han X, Qian J.

J Mol Diagn. 2016 Jul;18(4):535-45. doi: 10.1016/j.jmoldx.2016.02.005. Epub 2016 Apr 28.


Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island.

Wasserkort R, Kalmar A, Valcz G, Spisak S, Krispin M, Toth K, Tulassay Z, Sledziewski AZ, Molnar B.

BMC Cancer. 2013 Aug 30;13:398. doi: 10.1186/1471-2407-13-398.


Postoperative serum methylation levels of TAC1 and SEPT9 are independent predictors of recurrence and survival of patients with colorectal cancer.

Tham C, Chew M, Soong R, Lim J, Ang M, Tang C, Zhao Y, Ong SY, Liu Y.

Cancer. 2014 Oct 15;120(20):3131-41. doi: 10.1002/cncr.28802. Epub 2014 Jun 12.


High methylation of the SEPT9 gene in Chinese colorectal cancer patients.

Su XL, Wang YF, Li SJ, Zhang F, Cui HW.

Genet Mol Res. 2014 Jan 17;13(2):2513-20. doi: 10.4238/2014.January.17.5.


Colon cancer screening: which non-invasive filter tests?

Pox C.

Dig Dis. 2011;29 Suppl 1:56-9. doi: 10.1159/000331127. Epub 2011 Nov 15. Review.


Colorectal cancer screening with blood-based biomarkers: cost-effectiveness of methylated septin 9 DNA versus current strategies.

Ladabaum U, Allen J, Wandell M, Ramsey S.

Cancer Epidemiol Biomarkers Prev. 2013 Sep;22(9):1567-76. doi: 10.1158/1055-9965.EPI-13-0204. Epub 2013 Jun 24.


The stool DNA test is more accurate than the plasma septin 9 test in detecting colorectal neoplasia.

Ahlquist DA, Taylor WR, Mahoney DW, Zou H, Domanico M, Thibodeau SN, Boardman LA, Berger BM, Lidgard GP.

Clin Gastroenterol Hepatol. 2012 Mar;10(3):272-7.e1. doi: 10.1016/j.cgh.2011.10.008. Epub 2011 Oct 20.


Plasma methylated septin 9: a colorectal cancer screening marker.

Molnár B, Tóth K, Barták BK, Tulassay Z.

Expert Rev Mol Diagn. 2015 Feb;15(2):171-84. doi: 10.1586/14737159.2015.975212. Epub 2014 Nov 27.


[Expression of TROP2 mRNA in left-sided and right-sided colon cancer and its clinical significance].

Xu KY, Gu J.

Zhonghua Wei Chang Wai Ke Za Zhi. 2009 May;12(3):285-9. Chinese.


Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions.

Tänzer M, Balluff B, Distler J, Hale K, Leodolter A, Röcken C, Molnar B, Schmid R, Lofton-Day C, Schuster T, Ebert MP.

PLoS One. 2010 Feb 4;5(2):e9061. doi: 10.1371/journal.pone.0009061.


Serum methylation levels of TAC1. SEPT9 and EYA4 as diagnostic markers for early colorectal cancers: a pilot study.

Liu Y, Tham CK, Ong SY, Ho KS, Lim JF, Chew MH, Lim CK, Zhao Y, Tang CL, Eu KW.

Biomarkers. 2013 Aug;18(5):399-405. doi: 10.3109/1354750X.2013.798745.


The Relationship between the Methylated Septin-9 DNA Blood Test and Stool Occult Blood Test for Diagnosing Colorectal Cancer in Taiwanese People.

Chen CH, Yan SL, Yang TH, Chen SF, Yeh YH, Ou JJ, Lin CH, Lee YT, Chen CH.

J Clin Lab Anal. 2017 Jan;31(1). doi: 10.1002/jcla.22013. Epub 2016 Jul 8.


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