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Items: 1 to 20 of 95

1.

Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents.

Tarleton M, Gilbert J, Sakoff JA, McCluskey A.

Eur J Med Chem. 2012 Nov;57:65-73. doi: 10.1016/j.ejmech.2012.09.019. Epub 2012 Sep 18.

PMID:
23047225
2.

Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents.

Tarleton M, Dyson L, Gilbert J, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2013 Jan 1;21(1):333-47. doi: 10.1016/j.bmc.2012.10.003. Epub 2012 Oct 23.

PMID:
23176751
4.

Synthesis and anti-tumor activity of 2-amino-3-cyano-6-(1H-indol-3-yl)-4-phenylpyridine derivatives in vitro.

Zhang F, Zhao Y, Sun L, Ding L, Gu Y, Gong P.

Eur J Med Chem. 2011 Jul;46(7):3149-57. doi: 10.1016/j.ejmech.2011.03.055. Epub 2011 Apr 3.

PMID:
21514012
5.

A facile synthesis of novel bis-(indolyl)-1,3,4-oxadiazoles as potent cytotoxic agents.

Kumar D, Arun V, Maruthi Kumar N, Acosta G, Noel B, Shah K.

ChemMedChem. 2012 Nov;7(11):1915-20. doi: 10.1002/cmdc.201200363. Epub 2012 Sep 20.

PMID:
22997171
6.

Novel DNA intercalators without basic side chains as efficient antitumor agents: design, synthesis and evaluation of benzo-[c,d]-indol-malononitrile derivatives.

Li X, Wang Q, Qing Y, Lin Y, Zhang Y, Qian X, Cui J.

Bioorg Med Chem. 2010 May 1;18(9):3279-84. doi: 10.1016/j.bmc.2010.03.017. Epub 2010 Mar 21.

PMID:
20385497
7.

Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.

Berry JM, Bradshaw TD, Fichtner I, Ren R, Schwalbe CH, Wells G, Chew EH, Stevens MF, Westwell AD.

J Med Chem. 2005 Jan 27;48(2):639-44.

PMID:
15658878
8.

Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles.

Kumar D, Kumar NM, Chang KH, Gupta R, Shah K.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5897-900. doi: 10.1016/j.bmcl.2011.07.089. Epub 2011 Jul 30.

PMID:
21873049
9.

Synthesis and antiproliferative activity of 3-aryl-2-[1H(2H)-benzotriazol-1(2)-yl]acrylonitriles variously substituted: Part 4.

Carta A, Palomba M, Boatto G, Busonera B, Murreddu M, Loddo R.

Farmaco. 2004 Aug;59(8):637-44.

PMID:
15262533
10.

Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazoles.

Kumar D, Maruthi Kumar N, Chang KH, Shah K.

Eur J Med Chem. 2010 Oct;45(10):4664-8. doi: 10.1016/j.ejmech.2010.07.023. Epub 2010 Jul 21.

PMID:
20692741
11.

Multisubstituted indole-acrylonitrile hybrids as potential cytotoxic agents.

Ke S, Yang Z, Zhang Z, Liang Y, Wang K, Liu M, Shi L.

Bioorg Med Chem Lett. 2014 Apr 15;24(8):1907-11. doi: 10.1016/j.bmcl.2014.03.011. Epub 2014 Mar 17.

PMID:
24684840
12.

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.

Huang KH, Barta TE, Rice JW, Smith ED, Ommen AJ, Ma W, Veal JM, Fadden RP, Barabasz AF, Foley BE, Hughes PF, Hanson GJ, Markworth CJ, Silinski M, Partridge JM, Steed PM, Hall SE.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2550-4. doi: 10.1016/j.bmcl.2012.01.137. Epub 2012 Feb 15.

PMID:
22386527
13.

Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents.

Chen Z, Cao R, Shi B, Guo L, Sun J, Ma Q, Fan W, Song H.

Eur J Med Chem. 2011 Oct;46(10):5127-37. doi: 10.1016/j.ejmech.2011.08.027. Epub 2011 Aug 26.

PMID:
21875764
14.

Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions.

McCarroll AJ, Bradshaw TD, Westwell AD, Matthews CS, Stevens MF.

J Med Chem. 2007 Apr 5;50(7):1707-10. Epub 2007 Mar 8.

PMID:
17343370
15.

Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents.

Zhu W, Liu Y, Zhai X, Wang X, Zhu Y, Wu D, Zhou H, Gong P, Zhao Y.

Eur J Med Chem. 2012 Nov;57:162-75. doi: 10.1016/j.ejmech.2012.09.002. Epub 2012 Sep 10.

PMID:
23059545
16.

An efficient synthesis and biological study of novel indolyl-1,3,4-oxadiazoles as potent anticancer agents.

Kumar D, Sundaree S, Johnson EO, Shah K.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4492-4. doi: 10.1016/j.bmcl.2009.03.172. Epub 2009 Jun 13.

PMID:
19559607
17.

Synthesis, X-ray crystal structures, stabilities, and in vitro cytotoxic activities of new heteroarylacrylonitriles.

Saczewski F, Reszka P, Gdaniec M, Grünert R, Bednarski PJ.

J Med Chem. 2004 Jun 17;47(13):3438-49.

PMID:
15189040
18.

Synthesis and structure-activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents.

Marchand P, Antoine M, Le Baut G, Czech M, Baasner S, Günther E.

Bioorg Med Chem. 2009 Sep 15;17(18):6715-27. doi: 10.1016/j.bmc.2009.07.048. Epub 2009 Jul 25.

PMID:
19682911
19.

Antitumor activity and COMPARE analysis of bis-indole derivatives.

Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Landi L, Prata C, Dalla Sega FV, Caliceti C, Shoemaker RH.

Bioorg Med Chem. 2010 May 1;18(9):3004-11. doi: 10.1016/j.bmc.2010.03.063. Epub 2010 Mar 28.

PMID:
20395150
20.

Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line.

Virsodia V, Manvar A, Upadhyay K, Loriya R, Karia D, Jaggi M, Singh A, Mukherjee R, Shaikh MS, Coutinho EC, Shah A.

Eur J Med Chem. 2009 Mar;44(3):1355-62. doi: 10.1016/j.ejmech.2008.01.012. Epub 2008 Jan 25.

PMID:
18316139

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