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Items: 1 to 20 of 77

1.

Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.

Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17603-8. doi: 10.1073/pnas.1208807109. Epub 2012 Oct 8.

2.

Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.

Ansari KI, Mishra BP, Mandal SS.

Biochim Biophys Acta. 2008 Jan;1779(1):66-73. Epub 2007 Dec 3.

PMID:
18082152
3.

Altered expression of MLL methyltransferase family genes in breast cancer.

Rabello Ddo A, de Moura CA, de Andrade RV, Motoyama AB, Silva FP.

Int J Oncol. 2013 Aug;43(2):653-60. doi: 10.3892/ijo.2013.1981. Epub 2013 Jun 10.

PMID:
23754336
4.

Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.

Bach C, Mueller D, Buhl S, Garcia-Cuellar MP, Slany RK.

Oncogene. 2009 Feb 12;28(6):815-23. doi: 10.1038/onc.2008.443. Epub 2008 Dec 8.

PMID:
19060922
5.

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.

Issaeva I, Zonis Y, Rozovskaia T, Orlovsky K, Croce CM, Nakamura T, Mazo A, Eisenbach L, Canaani E.

Mol Cell Biol. 2007 Mar;27(5):1889-903. Epub 2006 Dec 18.

6.

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

Ansari KI, Mandal SS.

FEBS J. 2010 Apr;277(8):1790-804. doi: 10.1111/j.1742-4658.2010.07606.x. Epub 2010 Mar 4. Review.

7.

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.

Jiang H, Lu X, Shimada M, Dou Y, Tang Z, Roeder RG.

Nat Struct Mol Biol. 2013 Oct;20(10):1156-63. doi: 10.1038/nsmb.2656. Epub 2013 Sep 1.

8.

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

Wang J, Muntean AG, Wu L, Hess JL.

J Biol Chem. 2012 Dec 21;287(52):43410-6. doi: 10.1074/jbc.M112.423855. Epub 2012 Nov 5.

9.

Identification of the MLL2 complex as a coactivator for estrogen receptor alpha.

Mo R, Rao SM, Zhu YJ.

J Biol Chem. 2006 Jun 9;281(23):15714-20. Epub 2006 Apr 7.

10.

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.

Guo C, Chen LH, Huang Y, Chang CC, Wang P, Pirozzi CJ, Qin X, Bao X, Greer PK, McLendon RE, Yan H, Keir ST, Bigner DD, He Y.

Oncotarget. 2013 Nov;4(11):2144-53.

11.

Mechanisms of transformation by MLL.

Hess JL.

Crit Rev Eukaryot Gene Expr. 2004;14(4):235-54. Review.

PMID:
15663355
12.

Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.

Robert I, Aussems M, Keutgens A, Zhang X, Hennuy B, Viatour P, Vanstraelen G, Merville MP, Chapelle JP, de Leval L, Lambert F, Dejardin E, Gothot A, Chariot A.

Oncogene. 2009 Apr 2;28(13):1626-38. doi: 10.1038/onc.2009.6. Epub 2009 Feb 16.

PMID:
19219072
13.

The cancer COMPASS: navigating the functions of MLL complexes in cancer.

Ford DJ, Dingwall AK.

Cancer Genet. 2015 May;208(5):178-91. doi: 10.1016/j.cancergen.2015.01.005. Epub 2015 Jan 30. Review.

PMID:
25794446
14.

MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines.

Huntsman DG, Chin SF, Muleris M, Batley SJ, Collins VP, Wiedemann LM, Aparicio S, Caldas C.

Oncogene. 1999 Dec 23;18(56):7975-84.

15.

Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3.

Chauhan C, Zraly CB, Parilla M, Diaz MO, Dingwall AK.

Development. 2012 Jun;139(11):1997-2008. doi: 10.1242/dev.076687.

16.

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4.

Dhar SS, Lee SH, Kan PY, Voigt P, Ma L, Shi X, Reinberg D, Lee MG.

Genes Dev. 2012 Dec 15;26(24):2749-62. doi: 10.1101/gad.203356.112.

17.

Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice.

Kerimoglu C, Agis-Balboa RC, Kranz A, Stilling R, Bahari-Javan S, Benito-Garagorri E, Halder R, Burkhardt S, Stewart AF, Fischer A.

J Neurosci. 2013 Feb 20;33(8):3452-64. doi: 10.1523/JNEUROSCI.3356-12.2013. Erratum in: J Neurosci. 2013 Apr 17;33(16):7108.

18.

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML.

Mol Cell Biol. 2004 Jul;24(13):5639-49.

19.

PRAME expression is not associated with down-regulation of retinoic acid signaling in primary acute myeloid leukemia.

Steinbach D, Pfaffendorf N, Wittig S, Gruhn B.

Cancer Genet Cytogenet. 2007 Aug;177(1):51-4.

PMID:
17693191
20.

MLL2: A new mammalian member of the trx/MLL family of genes.

FitzGerald KT, Diaz MO.

Genomics. 1999 Jul 15;59(2):187-92.

PMID:
10409430
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