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Items: 1 to 20 of 165

1.

Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination.

Xu X, Keshwani M, Meyer K, Sarikas A, Taylor S, Pan ZQ.

J Biol Chem. 2012 Nov 23;287(48):40758-66. doi: 10.1074/jbc.M112.405209. Epub 2012 Oct 8.

2.

Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen.

Hartmann T, Xu X, Kronast M, Muehlich S, Meyer K, Zimmermann W, Hurwitz J, Pan ZQ, Engelhardt S, Sarikas A.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3371-6. doi: 10.1073/pnas.1401556111. Epub 2014 Feb 18.

3.

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.

Scheufele F, Wolf B, Kruse M, Hartmann T, Lempart J, Mühlich S, Pfeiffer AFH, Field LJ, Charron MJ, Pan ZQ, Engelhardt S, Sarikas A.

Cell Signal. 2014 Feb;26(2):233-239. doi: 10.1016/j.cellsig.2013.11.005. Epub 2013 Nov 9.

4.

The role of the cullin-5 e3 ubiquitin ligase in the regulation of insulin receptor substrate-1.

Hu CZ, Sethi JK, Hagen T.

Biochem Res Int. 2012;2012:282648. doi: 10.1155/2012/282648. Epub 2012 Dec 9.

5.

Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase.

Rajan MR, Fagerholm S, Jönsson C, Kjølhede P, Turkina MV, Strålfors P.

PLoS One. 2013;8(4):e59725. doi: 10.1371/journal.pone.0059725. Epub 2013 Apr 2.

6.

The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.

Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ.

Dev Cell. 2011 Nov 15;21(5):835-47. doi: 10.1016/j.devcel.2011.09.011. Epub 2011 Oct 25.

7.

Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.

Leng S, Zhang W, Zheng Y, Liberman Z, Rhodes CJ, Eldar-Finkelman H, Sun XJ.

J Endocrinol. 2010 Aug;206(2):171-81. doi: 10.1677/JOE-09-0456. Epub 2010 May 13.

8.

Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes.

Wang Y, Kim SM, Trnka MJ, Liu Y, Burlingame AL, Correia MA.

J Biol Chem. 2015 Feb 6;290(6):3308-32. doi: 10.1074/jbc.M114.611525. Epub 2014 Dec 1.

9.

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders.

Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP.

Nature. 2013 Feb 21;494(7437):375-9. doi: 10.1038/nature11834. Epub 2013 Jan 27.

PMID:
23354051
10.

Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells.

Wiza C, Herzfeld de Wiza D, Nascimento EB, Lehr S, Al-Hasani H, Ouwens DM.

Diabetologia. 2013 May;56(5):1118-28. doi: 10.1007/s00125-013-2861-9. Epub 2013 Mar 5.

PMID:
23460019
11.

Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction.

Wang Y, Guan S, Acharya P, Liu Y, Thirumaran RK, Brandman R, Schuetz EG, Burlingame AL, Correia MA.

Mol Cell Proteomics. 2012 Feb;11(2):M111.010132. doi: 10.1074/mcp.M111.010132. Epub 2011 Nov 17.

12.

Shooting the messenger: CULLIN' insulin signaling with Fbw8.

Mieulet V, Lamb RF.

Dev Cell. 2008 Jun;14(6):816-7. doi: 10.1016/j.devcel.2008.05.010.

13.

Phosphorylation of serine 323 of ASB2α is pivotal for the targeting of filamin A to degradation.

Zakaria R, Lamsoul I, Uttenweiler-Joseph S, Erard M, Monsarrat B, Burlet-Schiltz O, Moog-Lutz C, Lutz PG.

Cell Signal. 2013 Dec;25(12):2823-30. doi: 10.1016/j.cellsig.2013.09.011. Epub 2013 Sep 15.

PMID:
24044920
14.

Amino Acids Attenuate Insulin Action on Gluconeogenesis and Promote Fatty Acid Biosynthesis via mTORC1 Signaling Pathway in trout Hepatocytes.

Dai W, Panserat S, Plagnes-Juan E, Seiliez I, Skiba-Cassy S.

Cell Physiol Biochem. 2015;36(3):1084-100. doi: 10.1159/000430281. Epub 2015 Jun 25.

15.

Carrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1.

Bhattacharyya S, Feferman L, Tobacman JK.

J Biol Chem. 2015 Apr 24;290(17):10764-74. doi: 10.1074/jbc.M114.630053. Epub 2015 Mar 17.

16.

Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1).

Ge Y, Yoon MS, Chen J.

J Biol Chem. 2011 Oct 14;286(41):35675-82. doi: 10.1074/jbc.M111.262881. Epub 2011 Aug 18.

17.

The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.

Warren KJ, Fang X, Gowda NM, Thompson JJ, Heller NM.

J Biol Chem. 2016 Nov 25;291(48):24922-24930. Epub 2016 Oct 14.

PMID:
27742835
18.

mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.

Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E.

Mol Cell. 2012 Dec 28;48(6):875-87. doi: 10.1016/j.molcel.2012.09.029. Epub 2012 Nov 8.

19.

Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP.

Nie L, Wu H, Sun XH.

J Biol Chem. 2008 Jan 11;283(2):684-92. Epub 2007 Oct 25.

20.

Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling.

Gao S, Duan C, Gao G, Wang X, Yang H.

Int J Biochem Cell Biol. 2015 Jul;64:25-33. doi: 10.1016/j.biocel.2015.03.006. Epub 2015 Mar 23.

PMID:
25813876

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