Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 235

1.

Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure.

Hirota SA, Iablokov V, Tulk SE, Schenck LP, Becker H, Nguyen J, Al Bashir S, Dingle TC, Laing A, Liu J, Li Y, Bolstad J, Mulvey GL, Armstrong GD, MacNaughton WK, Muruve DA, MacDonald JA, Beck PL.

Infect Immun. 2012 Dec;80(12):4474-84. doi: 10.1128/IAI.00933-12. Epub 2012 Oct 8.

2.

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections.

Carter GP, Chakravorty A, Pham Nguyen TA, Mileto S, Schreiber F, Li L, Howarth P, Clare S, Cunningham B, Sambol SP, Cheknis A, Figueroa I, Johnson S, Gerding D, Rood JI, Dougan G, Lawley TD, Lyras D.

MBio. 2015 Jun 2;6(3):e00551. doi: 10.1128/mBio.00551-15.

3.

Contribution of adenosine A(2B) receptors in Clostridium difficile intoxication and infection.

Warren CA, Li Y, Calabrese GM, Freire RS, Zaja-Milatovic S, van Opstal E, Figler RA, Linden J, Guerrant RL.

Infect Immun. 2012 Dec;80(12):4463-73. doi: 10.1128/IAI.00782-12. Epub 2012 Oct 8.

4.

The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction.

Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA.

PLoS One. 2013 Nov 22;8(11):e81491. doi: 10.1371/journal.pone.0081491. eCollection 2013.

5.

Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome.

Ng J, Hirota SA, Gross O, Li Y, Ulke-Lemee A, Potentier MS, Schenck LP, Vilaysane A, Seamone ME, Feng H, Armstrong GD, Tschopp J, Macdonald JA, Muruve DA, Beck PL.

Gastroenterology. 2010 Aug;139(2):542-52, 552.e1-3. doi: 10.1053/j.gastro.2010.04.005. Epub 2010 Apr 13.

PMID:
20398664
6.

The enterotoxicity of Clostridium difficile toxins.

Sun X, Savidge T, Feng H.

Toxins (Basel). 2010 Jul;2(7):1848-80. doi: 10.3390/toxins2071848. Epub 2010 Jul 14. Review.

7.

Fidaxomicin inhibits Clostridium difficile toxin A-mediated enteritis in the mouse ileum.

Koon HW, Ho S, Hing TC, Cheng M, Chen X, Ichikawa Y, Kelly CP, Pothoulakis C.

Antimicrob Agents Chemother. 2014 Aug;58(8):4642-50. doi: 10.1128/AAC.02783-14. Epub 2014 Jun 2.

8.

Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models.

Steele J, Chen K, Sun X, Zhang Y, Wang H, Tzipori S, Feng H.

J Infect Dis. 2012 Feb 1;205(3):384-91. doi: 10.1093/infdis/jir748. Epub 2011 Dec 5.

9.

Study of the frequency of Clostridium difficile tcdA, tcdB, cdtA and cdtB genes in feces of Calves in south west of Iran.

Doosti A, Mokhtari-Farsani A.

Ann Clin Microbiol Antimicrob. 2014 Jun 5;13:21. doi: 10.1186/1476-0711-13-21.

10.

A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile.

Zhang BZ, Cai J, Yu B, Hua Y, Lau CC, Kao RY, Sze KH, Yuen KY, Huang JD.

BMC Infect Dis. 2016 Oct 22;16(1):596.

11.

Clostridium difficile toxins: mechanism of action and role in disease.

Voth DE, Ballard JD.

Clin Microbiol Rev. 2005 Apr;18(2):247-63. Review.

12.

CdtR Regulates TcdA and TcdB Production in Clostridium difficile.

Lyon SA, Hutton ML, Rood JI, Cheung JK, Lyras D.

PLoS Pathog. 2016 Jul 14;12(7):e1005758. doi: 10.1371/journal.ppat.1005758. eCollection 2016 Jul.

13.

Clostridium difficile Toxins TcdA and TcdB Cause Colonic Tissue Damage by Distinct Mechanisms.

Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Lacy DB.

Infect Immun. 2016 Sep 19;84(10):2871-7. doi: 10.1128/IAI.00583-16. Print 2016 Oct.

14.

Development of a recombinant toxin fragment vaccine for Clostridium difficile infection.

Karczewski J, Zorman J, Wang S, Miezeiewski M, Xie J, Soring K, Petrescu I, Rogers I, Thiriot DS, Cook JC, Chamberlin M, Xoconostle RF, Nahas DD, Joyce JG, Bodmer JL, Heinrichs JH, Secore S.

Vaccine. 2014 May 19;32(24):2812-8. doi: 10.1016/j.vaccine.2014.02.026. Epub 2014 Mar 21.

PMID:
24662701
15.

Toxin gene analysis of a variant strain of Clostridium difficile that causes human clinical disease.

Sambol SP, Merrigan MM, Lyerly D, Gerding DN, Johnson S.

Infect Immun. 2000 Oct;68(10):5480-7.

16.

Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic Clostridium difficile disease.

Steele J, Mukherjee J, Parry N, Tzipori S.

J Infect Dis. 2013 Jan 15;207(2):323-30. doi: 10.1093/infdis/jis669. Epub 2012 Nov 2.

17.

In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B.

D'Auria KM, Kolling GL, Donato GM, Warren CA, Gray MC, Hewlett EL, Papin JA.

Infect Immun. 2013 Oct;81(10):3814-24. doi: 10.1128/IAI.00869-13. Epub 2013 Jul 29.

18.

A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice.

Yang Z, Schmidt D, Liu W, Li S, Shi L, Sheng J, Chen K, Yu H, Tremblay JM, Chen X, Piepenbrink KH, Sundberg EJ, Kelly CP, Bai G, Shoemaker CB, Feng H.

J Infect Dis. 2014 Sep 15;210(6):964-72. doi: 10.1093/infdis/jiu196. Epub 2014 Mar 27.

19.

High temporal resolution of glucosyltransferase dependent and independent effects of Clostridium difficile toxins across multiple cell types.

D'Auria KM, Bloom MJ, Reyes Y, Gray MC, van Opstal EJ, Papin JA, Hewlett EL.

BMC Microbiol. 2015 Feb 4;15:7. doi: 10.1186/s12866-015-0361-4.

20.

Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model.

Qiu H, Cassan R, Johnstone D, Han X, Joyee AG, McQuoid M, Masi A, Merluza J, Hrehorak B, Reid R, Kennedy K, Tighe B, Rak C, Leonhardt M, Dupas B, Saward L, Berry JD, Nykiforuk CL.

PLoS One. 2016 Jun 23;11(6):e0157970. doi: 10.1371/journal.pone.0157970. eCollection 2016.

Supplemental Content

Support Center