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Items: 1 to 20 of 145

1.

Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection.

Sánchez-Moreno M, Gómez-Contreras F, Navarro P, Marín C, Olmo F, Yunta MJ, Sanz AM, Rosales MJ, Cano C, Campayo L.

J Med Chem. 2012 Nov 26;55(22):9900-13. doi: 10.1021/jm3011004. Epub 2012 Oct 22.

PMID:
23043291
2.

Synthesis and evaluation of in vitro and in vivo trypanocidal properties of a new imidazole-containing nitrophthalazine derivative.

Olmo F, Gómez-Contreras F, Navarro P, Marín C, Yunta MJ, Cano C, Campayo L, Martín-Oliva D, Rosales MJ, Sánchez-Moreno M.

Eur J Med Chem. 2015 Dec 1;106:106-19. doi: 10.1016/j.ejmech.2015.10.034. Epub 2015 Oct 23.

PMID:
26523668
3.

In vivo trypanosomicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against acute and chronic phases of Chagas disease.

Sánchez-Moreno M, Sanz AM, Gómez-Contreras F, Navarro P, Marín C, Ramírez-Macias I, Rosales MJ, Olmo F, Garcia-Aranda I, Campayo L, Cano C, Arrebola F, Yunta MJ.

J Med Chem. 2011 Feb 24;54(4):970-9. doi: 10.1021/jm101198k. Epub 2011 Jan 13.

PMID:
21229977
4.

Efficient inhibition of iron superoxide dismutase and of Trypanosoma cruzi growth by benzo[g]phthalazine derivatives functionalized with one or two imidazole rings.

Sanz AM, Gómez-Contreras F, Navarro P, Sánchez-Moreno M, Boutaleb-Charki S, Campuzano J, Pardo M, Osuna A, Cano C, Yunta MJ, Campayo L.

J Med Chem. 2008 Mar 27;51(6):1962-6. doi: 10.1021/jm701179m. Epub 2008 Feb 23.

PMID:
18293910
5.

An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase.

Olmo F, Urbanová K, Rosales MJ, Martín-Escolano R, Sánchez-Moreno M, Marín C.

Int J Parasitol Drugs Drug Resist. 2015 Jun 20;5(3):110-6. doi: 10.1016/j.ijpddr.2015.05.002. eCollection 2015 Dec.

6.

In vitro leishmanicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against Leishmania infantum and Leishmania braziliensis species.

Sánchez-Moreno M, Gómez-Contreras F, Navarro P, Marín C, Ramírez-Macías I, Olmo F, Sanz AM, Campayo L, Cano C, Yunta MJ.

J Antimicrob Chemother. 2012 Feb;67(2):387-97. doi: 10.1093/jac/dkr480. Epub 2011 Nov 29.

PMID:
22127582
7.

In vitro and in vivo trypanosomicidal activity of pyrazole-containing macrocyclic and macrobicyclic polyamines: their action on acute and chronic phases of Chagas disease.

Sánchez-Moreno M, Marín C, Navarro P, Lamarque L, García-España E, Miranda C, Huertas O, Olmo F, Gómez-Contreras F, Pitarch J, Arrebola F.

J Med Chem. 2012 May 10;55(9):4231-43. doi: 10.1021/jm2017144. Epub 2012 Apr 24.

PMID:
22443115
8.

In vitro and in vivo identification of tetradentated polyamine complexes as highly efficient metallodrugs against Trypanosoma cruzi.

Olmo F, Cussó O, Marín C, Rosales MJ, Urbanová K, Krauth-Siegel RL, Costas M, Ribas X, Sánchez-Moreno M.

Exp Parasitol. 2016 May;164:20-30. doi: 10.1016/j.exppara.2016.02.004. Epub 2016 Feb 10.

PMID:
26874306
9.

Scorpiand-like azamacrocycles prevent the chronic establishment of Trypanosoma cruzi in a murine model.

Olmo F, Marín C, Clares MP, Blasco S, Albelda MT, Soriano C, Gutiérrez-Sánchez R, Arrebola-Vargas F, García-España E, Sánchez-Moreno M.

Eur J Med Chem. 2013;70:189-98. doi: 10.1016/j.ejmech.2013.09.048. Epub 2013 Oct 9.

PMID:
24158012
10.

Prospects of an alternative treatment against Trypanosoma cruzi based on abietic acid derivatives show promising results in Balb/c mouse model.

Olmo F, Guardia JJ, Marin C, Messouri I, Rosales MJ, Urbanová K, Chayboun I, Chahboun R, Alvarez-Manzaneda EJ, Sánchez-Moreno M.

Eur J Med Chem. 2015 Jan 7;89:683-90. doi: 10.1016/j.ejmech.2014.11.004. Epub 2014 Nov 3.

PMID:
25462275
11.

In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.

Moreno-Viguri E, Jiménez-Montes C, Martín-Escolano R, Santivañez-Veliz M, Martin-Montes A, Azqueta A, Jimenez-Lopez M, Zamora Ledesma S, Cirauqui N, López de Ceráin A, Marín C, Sánchez-Moreno M, Pérez-Silanes S.

J Med Chem. 2016 Dec 22;59(24):10929-10945. doi: 10.1021/acs.jmedchem.6b00784. Epub 2016 Dec 6.

PMID:
28002965
12.

In vitro and in vivo trypanocidal activity of flavonoids from Delphinium staphisagria against Chagas disease.

Marín C, Ramírez-Macías I, López-Céspedes A, Olmo F, Villegas N, Díaz JG, Rosales MJ, Gutiérrez-Sánchez R, Sánchez-Moreno M.

J Nat Prod. 2011 Apr 25;74(4):744-50. doi: 10.1021/np1008043. Epub 2011 Apr 5.

PMID:
21466157
13.

Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins.

Búa J, Fichera LE, Fuchs AG, Potenza M, Dubin M, Wenger RO, Moretti G, Scabone CM, Ruiz AM.

Parasitology. 2008 Feb;135(2):217-28. Epub 2007 Oct 9.

PMID:
17922928
14.

New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.

Carneiro PF, do Nascimento SB, Pinto AV, Pinto Mdo C, Lechuga GC, Santos DO, dos Santos Júnior HM, Resende JA, Bourguignon SC, Ferreira VF.

Bioorg Med Chem. 2012 Aug 15;20(16):4995-5000. doi: 10.1016/j.bmc.2012.06.027. Epub 2012 Jun 21.

PMID:
22795899
15.

Taiwaniaquinoid and abietane quinone derivatives with trypanocidal activity against T. cruzi and Leishmania spp.

Ramírez-Macías I, Marín C, Es-Samti H, Fernández A, Guardia JJ, Zentar H, Agil A, Chahboun R, Alvarez-Manzaneda E, Sánchez-Moreno M.

Parasitol Int. 2012 Sep;61(3):405-13. doi: 10.1016/j.parint.2012.02.001. Epub 2012 Feb 16.

PMID:
22366342
16.

Imidazole-containing phthalazine derivatives inhibit Fe-SOD performance in Leishmania species and are active in vitro against visceral and mucosal leishmaniasis.

Sánchez-Moreno M, Gómez-Contreras F, Navarro P, Marín C, Ramírez-Macías I, Rosales MJ, Campayo L, Cano C, Sanz AM, Yunta MJ.

Parasitology. 2015 Jul;142(8):1115-29. doi: 10.1017/S0031182015000219. Epub 2015 Mar 31. Erratum in: Parasitology. 2015 Sep;142(10):1350.

PMID:
25823476
17.

Benznidazole alters the pattern of Cyclophosphamide-induced reactivation in experimental Trypanosoma cruzi-dependent lineage infection.

Santos DM, Martins TA, Caldas IS, Diniz LF, Machado-Coelho GL, Carneiro CM, Oliveira Rde P, Talvani A, Lana M, Bahia MT.

Acta Trop. 2010 Feb;113(2):134-8. doi: 10.1016/j.actatropica.2009.10.007. Epub 2009 Oct 23.

PMID:
19854145
18.

Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.

Seguel V, Castro L, Reigada C, Cortes L, Díaz MV, Miranda MR, Pereira CA, Lapier M, Campos-Estrada C, Morello A, Kemmerling U, Maya JD, López-Muñoz R.

Exp Parasitol. 2016 Dec;171:23-32. doi: 10.1016/j.exppara.2016.10.007. Epub 2016 Oct 8.

PMID:
27729250
19.

Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from beta-lapachone.

De Moura KC, Salomão K, Menna-Barreto RF, Emery FS, Pinto Mdo C, Pinto AV, de Castro SL.

Eur J Med Chem. 2004 Jul;39(7):639-45.

PMID:
15236845
20.

Imidazoles from nitroallylic acetates and α-bromonitroalkenes with amidines: synthesis and trypanocidal activity studies.

Gopi E, Kumar T, Menna-Barreto RF, Valença WO, da Silva Júnior EN, Namboothiri IN.

Org Biomol Chem. 2015 Oct 14;13(38):9862-71. doi: 10.1039/c5ob01444a.

PMID:
26288376

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