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Items: 1 to 20 of 84

1.

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA.

Science. 2012 Nov 9;338(6108):818-22. doi: 10.1126/science.1226191. Epub 2012 Oct 4.

2.

Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress.

Back SH, Lee K, Vink E, Kaufman RJ.

J Biol Chem. 2006 Jul 7;281(27):18691-706. Epub 2006 Apr 27.

3.

Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis.

Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M.

Sci Signal. 2014 Jun 10;7(329):ra54. doi: 10.1126/scisignal.2004983.

4.

HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction.

Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, Samali A.

PLoS Biol. 2010 Jul 6;8(7):e1000410. doi: 10.1371/journal.pbio.1000410.

5.

RNF13 protein regulates endoplasmic reticulum stress induced apoptosis in dopaminergic SH-SY5Y cells by enhancing IRE1α stability.

Arshad A, Gu X, Arshad M.

J Recept Signal Transduct Res. 2014 Apr;34(2):119-24. doi: 10.3109/10799893.2013.863920. Epub 2013 Dec 5.

PMID:
24303962
6.

IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis.

So JS, Cho S, Min SH, Kimball SR, Lee AH.

Mol Cell Biol. 2015 Aug;35(16):2761-70. doi: 10.1128/MCB.00215-15. Epub 2015 Jun 1.

7.

Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress.

Bouchecareilh M, Higa A, Fribourg S, Moenner M, Chevet E.

FASEB J. 2011 Sep;25(9):3115-29. doi: 10.1096/fj.11-182931. Epub 2011 Jun 16.

PMID:
21680894
8.

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR.

Cell. 2014 Jul 31;158(3):534-48. doi: 10.1016/j.cell.2014.07.002. Epub 2014 Jul 10.

9.

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

Sandow JJ, Dorstyn L, O'Reilly LA, Tailler M, Kumar S, Strasser A, Ekert PG.

Cell Death Differ. 2014 Mar;21(3):475-80. doi: 10.1038/cdd.2013.168. Epub 2013 Nov 29.

10.

MicroRNA-1291-mediated silencing of IRE1α enhances Glypican-3 expression.

Maurel M, Dejeans N, Taouji S, Chevet E, Grosset CF.

RNA. 2013 Jun;19(6):778-88. doi: 10.1261/rna.036483.112. Epub 2013 Apr 18.

11.

Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia.

Sun H, Lin DC, Guo X, Kharabi Masouleh B, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP.

Oncotarget. 2016 Apr 5;7(14):18736-49. doi: 10.18632/oncotarget.7702.

13.

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR.

Cell. 2009 Aug 7;138(3):562-75. doi: 10.1016/j.cell.2009.07.017.

14.

Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy.

Wang F, Weng H, Quon MJ, Yu J, Wang JY, Hueber AO, Yang P.

Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E861-73. doi: 10.1152/ajpendo.00215.2015. Epub 2015 Sep 29.

15.

Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor.

Son SM, Byun J, Roh SE, Kim SJ, Mook-Jung I.

Cell Death Dis. 2014 Apr 17;5:e1188. doi: 10.1038/cddis.2014.129.

16.

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis.

Zhang K, Wang S, Malhotra J, Hassler JR, Back SH, Wang G, Chang L, Xu W, Miao H, Leonardi R, Chen YE, Jackowski S, Kaufman RJ.

EMBO J. 2011 Apr 6;30(7):1357-75. doi: 10.1038/emboj.2011.52. Epub 2011 Mar 15.

17.

Ask1 gene deletion blocks maternal diabetes-induced endoplasmic reticulum stress in the developing embryo by disrupting the unfolded protein response signalosome.

Wang F, Wu Y, Gu H, Reece EA, Fang S, Gabbay-Benziv R, Aberdeen G, Yang P.

Diabetes. 2015 Mar;64(3):973-88. doi: 10.2337/db14-0409. Epub 2014 Sep 23.

18.

A functional link between the co-translational protein translocation pathway and the UPR.

Plumb R, Zhang ZR, Appathurai S, Mariappan M.

Elife. 2015 May 20;4. doi: 10.7554/eLife.07426.

19.

Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins.

Oikawa D, Kimata Y, Kohno K, Iwawaki T.

Exp Cell Res. 2009 Sep 10;315(15):2496-504. doi: 10.1016/j.yexcr.2009.06.009. Epub 2009 Jun 16.

PMID:
19538957
20.

Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α.

Itzhak D, Bright M, McAndrew P, Mirza A, Newbatt Y, Strover J, Widya M, Thompson A, Morgan G, Collins I, Davies F.

BMC Biochem. 2014 Feb 13;15:3. doi: 10.1186/1471-2091-15-3.

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