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Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development.

Newbigging S, Zhang M, Saba JD.

Gene Expr Patterns. 2013 Jan-Feb;13(1-2):21-9. doi: 10.1016/j.gep.2012.09.001. Epub 2012 Oct 4.


Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.

Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD.

J Lipid Res. 2012 Sep;53(9):1920-31. doi: 10.1194/jlr.M028084. Epub 2012 Jul 9.


First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.

Brizuela L, Ader I, Mazerolles C, Bocquet M, Malavaud B, Cuvillier O.

Mol Cancer Ther. 2012 Sep;11(9):1841-51. doi: 10.1158/1535-7163.MCT-12-0227. Epub 2012 Jul 10.


Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.

Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17384-9. Epub 2006 Nov 7.


Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease.

Ceccom J, Loukh N, Lauwers-Cances V, Touriol C, Nicaise Y, Gentil C, Uro-Coste E, Pitson S, Maurage CA, Duyckaerts C, Cuvillier O, Delisle MB.

Acta Neuropathol Commun. 2014 Jan 27;2:12. doi: 10.1186/2051-5960-2-12.


Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression.

de la Garza-Rodea AS, Baldwin DM, Oskouian B, Place RF, Bandhuvula P, Kumar A, Saba JD.

FASEB J. 2014 Jan;28(1):506-19. doi: 10.1096/fj.13-233155. Epub 2013 Oct 24.


Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm.

Kihara A, Ikeda M, Kariya Y, Lee EY, Lee YM, Igarashi Y.

J Biol Chem. 2003 Apr 18;278(16):14578-85. Epub 2003 Feb 12.


S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase.

Saba JD, de la Garza-Rodea AS.

Biochim Biophys Acta. 2013 Jan;1831(1):167-75. doi: 10.1016/j.bbalip.2012.06.009. Epub 2012 Jun 28. Review.


Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation.

Colié S, Van Veldhoven PP, Kedjouar B, Bedia C, Albinet V, Sorli SC, Garcia V, Djavaheri-Mergny M, Bauvy C, Codogno P, Levade T, Andrieu-Abadie N.

Cancer Res. 2009 Dec 15;69(24):9346-53. doi: 10.1158/0008-5472.CAN-09-2198. Epub .


Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis.

Kariya Y, Kihara A, Ikeda M, Kikuchi F, Nakamura S, Hashimoto S, Choi CH, Lee YM, Igarashi Y.

Genes Cells. 2005 Jun;10(6):605-15.


Lyase to live by: sphingosine phosphate lyase as a therapeutic target.

Kumar A, Saba JD.

Expert Opin Ther Targets. 2009 Aug;13(8):1013-25. doi: 10.1517/14728220903039722. Review.


Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast.

Zhou J, Saba JD.

Biochem Biophys Res Commun. 1998 Jan 26;242(3):502-7.


Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.

Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD.

J Clin Invest. 2014 Dec;124(12):5368-84. doi: 10.1172/JCI74188. Epub 2014 Oct 27.


Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight.

Fyrst H, Saba JD.

Biochim Biophys Acta. 2008 Sep;1781(9):448-58. doi: 10.1016/j.bbalip.2008.05.005. Epub 2008 Jun 17. Review.


Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme.

Ikeda M, Kihara A, Kariya Y, Lee YM, Igarashi Y.

Biochem Biophys Res Commun. 2005 Apr 8;329(2):474-9.


Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren.

Bandhuvula P, Saba JD.

Trends Mol Med. 2007 May;13(5):210-7. Epub 2007 Apr 6. Review.


S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart.

Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1753-61. doi: 10.1152/ajpheart.00946.2010. Epub 2011 Feb 18.


Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity.

Seo YJ, Blake C, Alexander S, Hahm B.

J Virol. 2010 Aug;84(16):8124-31. doi: 10.1128/JVI.00510-10. Epub 2010 Jun 2.

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