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Variance in total levels of phospholipase C zeta (PLC-ζ) in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability.

Kashir J, Jones C, Mounce G, Ramadan WM, Lemmon B, Heindryckx B, de Sutter P, Parrington J, Turner K, Child T, McVeigh E, Coward K.

Fertil Steril. 2013 Jan;99(1):107-17. doi: 10.1016/j.fertnstert.2012.09.001. Epub 2012 Oct 3.


Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection.

Yelumalai S, Yeste M, Jones C, Amdani SN, Kashir J, Mounce G, Da Silva SJ, Barratt CL, McVeigh E, Coward K.

Fertil Steril. 2015 Sep;104(3):561-8.e4. doi: 10.1016/j.fertnstert.2015.05.018. Epub 2015 Jun 18.


Motile sperm organelle morphology evaluation-selected globozoospermic human sperm with an acrosomal bud exhibits novel patterns and higher levels of phospholipase C zeta.

Kashir J, Sermondade N, Sifer C, Oo SL, Jones C, Mounce G, Turner K, Child T, McVeigh E, Coward K.

Hum Reprod. 2012 Nov;27(11):3150-60. doi: 10.1093/humrep/des312. Epub 2012 Aug 31.


Phospholipase C-zeta deficiency as a cause for repetitive oocyte fertilization failure during ovarian stimulation for in vitro fertilization with ICSI: a case report.

Chithiwala ZH, Lee HC, Hill DL, Jellerette-Nolan T, Fissore R, Grow D, Dumesic DA.

J Assist Reprod Genet. 2015 Sep;32(9):1415-9. doi: 10.1007/s10815-015-0531-1. Epub 2015 Jul 15.


Phospholipase C zeta (PLCζ): oocyte activation and clinical links to male factor infertility.

Amdani SN, Jones C, Coward K.

Adv Biol Regul. 2013 Sep;53(3):292-308. doi: 10.1016/j.jbior.2013.07.005. Epub 2013 Jul 17. Review.


Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.

Heytens E, Parrington J, Coward K, Young C, Lambrecht S, Yoon SY, Fissore RA, Hamer R, Deane CM, Ruas M, Grasa P, Soleimani R, Cuvelier CA, Gerris J, Dhont M, Deforce D, Leybaert L, De Sutter P.

Hum Reprod. 2009 Oct;24(10):2417-28. doi: 10.1093/humrep/dep207. Epub 2009 Jul 7.


Phospholipase C zeta undergoes dynamic changes in its pattern of localization in sperm during capacitation and the acrosome reaction.

Young C, Grasa P, Coward K, Davis LC, Parrington J.

Fertil Steril. 2009 May;91(5 Suppl):2230-42. doi: 10.1016/j.fertnstert.2008.05.021. Epub 2008 Aug 16.


Sperm involved in recurrent partial hydatidiform moles cannot induce the normal pattern of calcium oscillations.

Nikiforaki D, Vanden Meerschaut F, De Gheselle S, Qian C, Van den Abbeel E, De Vos WH, Deroo T, De Sutter P, Heindryckx B.

Fertil Steril. 2014 Aug;102(2):581-588.e1. doi: 10.1016/j.fertnstert.2014.05.004. Epub 2014 Jun 12.


Phospholipase C zeta (PLCζ) and male infertility: Clinical update and topical developments.

Amdani SN, Yeste M, Jones C, Coward K.

Adv Biol Regul. 2016 May;61:58-67. doi: 10.1016/j.jbior.2015.11.009. Epub 2015 Nov 30. Review.


Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells.

Kashir J, Konstantinidis M, Jones C, Heindryckx B, De Sutter P, Parrington J, Wells D, Coward K.

Fertil Steril. 2012 Aug;98(2):423-31. doi: 10.1016/j.fertnstert.2012.05.002. Epub 2012 May 24.


The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation.

Nomikos M, Kashir J, Lai FA.

Biochem J. 2017 Oct 23;474(21):3659-3673. doi: 10.1042/BCJ20160521. Review.


PLCζ sequence, protein levels, and distribution in human sperm do not correlate with semen characteristics and fertilization rates after ICSI.

Ferrer-Vaquer A, Barragan M, Freour T, Vernaeve V, Vassena R.

J Assist Reprod Genet. 2016 Jun;33(6):747-56. doi: 10.1007/s10815-016-0718-0. Epub 2016 May 2.


Diagnostic and prognostic value of calcium oscillatory pattern analysis for patients with ICSI fertilization failure.

Vanden Meerschaut F, Leybaert L, Nikiforaki D, Qian C, Heindryckx B, De Sutter P.

Hum Reprod. 2013 Jan;28(1):87-98. doi: 10.1093/humrep/des368. Epub 2012 Oct 18.


Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.

Kashir J, Jones C, Lee HC, Rietdorf K, Nikiforaki D, Durrans C, Ruas M, Tee ST, Heindryckx B, Galione A, De Sutter P, Fissore RA, Parrington J, Coward K.

Hum Reprod. 2011 Dec;26(12):3372-87. doi: 10.1093/humrep/der336. Epub 2011 Oct 18.


Reduced fertilization after ICSI and abnormal phospholipase C zeta presence in spermatozoa from the wobbler mouse.

Heytens E, Schmitt-John T, Moser JM, Jensen NM, Soleimani R, Young C, Coward K, Parrington J, De Sutter P.

Reprod Biomed Online. 2010 Dec;21(6):742-9. doi: 10.1016/j.rbmo.2010.07.006. Epub 2010 Jul 18.


Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection.

Swann K, Windsor S, Campbell K, Elgmati K, Nomikos M, Zernicka-Goetz M, Amso N, Lai FA, Thomas A, Graham C.

Fertil Steril. 2012 Mar;97(3):742-7. doi: 10.1016/j.fertnstert.2011.12.013. Epub 2012 Jan 2.


Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility.

Nomikos M, Yu Y, Elgmati K, Theodoridou M, Campbell K, Vassilakopoulou V, Zikos C, Livaniou E, Amso N, Nounesis G, Swann K, Lai FA.

Fertil Steril. 2013 Jan;99(1):76-85. doi: 10.1016/j.fertnstert.2012.08.035. Epub 2012 Sep 21.


Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP.

Escoffier J, Lee HC, Yassine S, Zouari R, Martinez G, Karaouzène T, Coutton C, Kherraf ZE, Halouani L, Triki C, Nef S, Thierry-Mieg N, Savinov SN, Fissore R, Ray PF, Arnoult C.

Hum Mol Genet. 2016 Mar 1;25(5):878-91. doi: 10.1093/hmg/ddv617. Epub 2015 Dec 31.


Successful pregnancy after oocyte activation by a calcium ionophore for a patient with recurrent intracytoplasmic sperm injection failure, with an assessment of oocyte activation and sperm centrosomal function using bovine eggs.

Terada Y, Hasegawa H, Takahashi A, Ugajin T, Yaegashi N, Okamura K.

Fertil Steril. 2009 Mar;91(3):935.e11-4. doi: 10.1016/j.fertnstert.2008.09.043. Epub 2008 Nov 14.


Use of Mammalian eggs for assessment of human sperm function: molecular and cellular analyses of fertilization by intracytoplasmic sperm injection.

Terada Y, Nakamura S, Morita J, Tachibana M, Morito Y, Ito K, Murakami T, Yaegashi N, Okamura K.

Am J Reprod Immunol. 2004 Apr;51(4):290-3.


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