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A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster.

Pickering AM, Staab TA, Tower J, Sieburth D, Davies KJ.

J Exp Biol. 2013 Feb 15;216(Pt 4):543-53. doi: 10.1242/jeb.074757. Epub 2012 Oct 4.


Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans.

Raynes R, Juarez C, Pomatto LC, Sieburth D, Davies KJ.

J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):143-151. doi: 10.1093/gerona/glw093. Epub 2016 Jun 23.


Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway.

Keith SA, Maddux SK, Zhong Y, Chinchankar MN, Ferguson AA, Ghazi A, Fisher AL.

PLoS Genet. 2016 Feb 1;12(2):e1005823. doi: 10.1371/journal.pgen.1005823. eCollection 2016 Feb.


Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome.

Grimberg KB, Beskow A, Lundin D, Davis MM, Young P.

Mol Cell Biol. 2011 Feb;31(4):897-909. doi: 10.1128/MCB.00799-10. Epub 2010 Dec 13.


Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.

Tsakiri EN, Sykiotis GP, Papassideri IS, Terpos E, Dimopoulos MA, Gorgoulis VG, Bohmann D, Trougakos IP.

Aging Cell. 2013 Oct;12(5):802-13. doi: 10.1111/acel.12111. Epub 2013 Jun 28.


Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.

Pickering AM, Linder RA, Zhang H, Forman HJ, Davies KJ.

J Biol Chem. 2012 Mar 23;287(13):10021-31. doi: 10.1074/jbc.M111.277145. Epub 2012 Feb 3.


SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.

Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M.

Free Radic Biol Med. 2015 Nov;88(Pt B):290-301. doi: 10.1016/j.freeradbiomed.2015.06.008. Epub 2015 Aug 5. Review.


Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans.

Ishikado A, Sono Y, Matsumoto M, Robida-Stubbs S, Okuno A, Goto M, King GL, Blackwell TK, Makino T.

Free Radic Biol Med. 2013 Dec;65:1506-15. doi: 10.1016/j.freeradbiomed.2012.12.006. Epub 2012 Dec 28.


20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans.

Chondrogianni N, Georgila K, Kourtis N, Tavernarakis N, Gonos ES.

FASEB J. 2015 Feb;29(2):611-22. doi: 10.1096/fj.14-252189. Epub 2014 Nov 13.


Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone.

Przybysz AJ, Choe KP, Roberts LJ, Strange K.

Mech Ageing Dev. 2009 Jun;130(6):357-69. doi: 10.1016/j.mad.2009.02.004. Epub 2009 Mar 13.


Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans.

Kampkötter A, Gombitang Nkwonkam C, Zurawski RF, Timpel C, Chovolou Y, Wätjen W, Kahl R.

Arch Toxicol. 2007 Dec;81(12):849-58. Epub 2007 Jun 6.


Inhibition of the oxidative stress response by heat stress in Caenorhabditis elegans.

Crombie TA, Tang L, Choe KP, Julian D.

J Exp Biol. 2016 Jul 15;219(Pt 14):2201-11. doi: 10.1242/jeb.135327. Epub 2016 May 13.


The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.

Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K.

Genes Dev. 2005 Oct 1;19(19):2278-83. Epub 2005 Sep 15.


The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster.

Pomatto LCD, Wong S, Carney C, Shen B, Tower J, Davies KJA.

Aging (Albany NY). 2017 Apr;9(4):1153-1185. doi: 10.18632/aging.101218.


Stress induced nuclear granules form in response to accumulation of misfolded proteins in Caenorhabditis elegans.

Sampuda KM, Riley M, Boyd L.

BMC Cell Biol. 2017 Apr 19;18(1):18. doi: 10.1186/s12860-017-0136-x.


Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.

Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK.

PLoS Genet. 2011 Jun;7(6):e1002119. doi: 10.1371/journal.pgen.1002119. Epub 2011 Jun 9.


The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans.

Staab TA, Griffen TC, Corcoran C, Evgrafov O, Knowles JA, Sieburth D.

PLoS Genet. 2013 Mar;9(3):e1003354. doi: 10.1371/journal.pgen.1003354. Epub 2013 Mar 21.


skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans.

Ferguson AA, Springer MG, Fisher AL.

Mol Cell Biol. 2010 Jun;30(11):2651-67. doi: 10.1128/MCB.01340-09. Epub 2010 Mar 29.


Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans.

Lashmanova E, Proshkina E, Zhikrivetskaya S, Shevchenko O, Marusich E, Leonov S, Melerzanov A, Zhavoronkov A, Moskalev A.

Pharmacol Res. 2015 Oct;100:228-41. doi: 10.1016/j.phrs.2015.08.009. Epub 2015 Aug 18.


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