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Items: 1 to 20 of 115

1.

A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors.

Li Z, Zheng W, Wang Z, Zeng Z, Zhan H, Li C, Zhou L, Yan C, Spitsbergen JM, Gong Z.

Dis Model Mech. 2013 Mar;6(2):414-23. doi: 10.1242/dmm.010462. Epub 2012 Oct 4.

2.

Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes.

Li Z, Zheng W, Li H, Li C, Gong Z.

PLoS One. 2015 Jul 6;10(7):e0132319. doi: 10.1371/journal.pone.0132319. eCollection 2015.

3.

Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma.

Zheng W, Li Z, Nguyen AT, Li C, Emelyanov A, Gong Z.

PLoS One. 2014 Mar 14;9(3):e91179. doi: 10.1371/journal.pone.0091179. eCollection 2014.

4.

MYC-regulated genes involved in liver cell dysplasia identified in a transgenic model of liver cancer.

Hunecke D, Spanel R, Länger F, Nam SW, Borlak J.

J Pathol. 2012 Dec;228(4):520-33. doi: 10.1002/path.4059. Epub 2012 Nov 6.

PMID:
22653869
5.

A high level of liver-specific expression of oncogenic Kras(V12) drives robust liver tumorigenesis in transgenic zebrafish.

Nguyen AT, Emelyanov A, Koh CH, Spitsbergen JM, Lam SH, Mathavan S, Parinov S, Gong Z.

Dis Model Mech. 2011 Nov;4(6):801-13. doi: 10.1242/dmm.007831. Epub 2011 Jul 4.

6.

Myc-induced liver tumors in transgenic zebrafish can regress in tp53 null mutation.

Sun L, Nguyen AT, Spitsbergen JM, Gong Z.

PLoS One. 2015 Jan 22;10(1):e0117249. doi: 10.1371/journal.pone.0117249. eCollection 2015.

7.

Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis.

Coulouarn C, Gomez-Quiroz LE, Lee JS, Kaposi-Novak P, Conner EA, Goldina TA, Onishchenko GE, Factor VM, Thorgeirsson SS.

Hepatology. 2006 Oct;44(4):1003-11.

PMID:
17006931
8.
9.

Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease.

Zimonjic DB, Ullmannova-Benson V, Factor VM, Thorgeirsson SS, Popescu NC.

Cancer Genet Cytogenet. 2009 May;191(1):17-26. doi: 10.1016/j.cancergencyto.2008.12.014.

10.

Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish.

Lu JW, Yang WY, Tsai SM, Lin YM, Chang PH, Chen JR, Wang HD, Wu JL, Jin SL, Yuh CH.

PLoS One. 2013 Oct 9;8(10):e76951. doi: 10.1371/journal.pone.0076951. eCollection 2013.

11.

Transcriptomic analysis of a transgenic zebrafish hepatocellular carcinoma model reveals a prominent role of immune responses in tumour progression and regression.

Li Z, Luo H, Li C, Huo X, Yan C, Huang X, Al-Haddawi M, Mathavan S, Gong Z.

Int J Cancer. 2014 Oct 1;135(7):1564-73. doi: 10.1002/ijc.28794. Epub 2014 Mar 4.

12.

Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC.

Ritorto MS, Rhode H, Vogel A, Borlak J.

Biol Chem. 2016 Nov 1;397(11):1147-1162. doi: 10.1515/hsz-2016-0133.

PMID:
27232633
13.

Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha.

Santoni-Rugiu E, Nagy P, Jensen MR, Factor VM, Thorgeirsson SS.

Am J Pathol. 1996 Aug;149(2):407-28.

15.

Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2.

Wang B, Hsu SH, Wang X, Kutay H, Bid HK, Yu J, Ganju RK, Jacob ST, Yuneva M, Ghoshal K.

Hepatology. 2014 Feb;59(2):555-66. doi: 10.1002/hep.26712. Epub 2013 Dec 20.

16.

Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing.

Aravalli RN, Talbot NC, Steer CJ.

World J Gastroenterol. 2015 Feb 21;21(7):2011-29. doi: 10.3748/wjg.v21.i7.2011.

17.

Characterization of MYC-induced tumorigenesis by in situ lipid profiling.

Perry RH, Bellovin DI, Shroff EH, Ismail AI, Zabuawala T, Felsher DW, Zare RN.

Anal Chem. 2013 May 7;85(9):4259-62. doi: 10.1021/ac400479j. Epub 2013 Apr 18.

18.

Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish.

Li Z, Huang X, Zhan H, Zeng Z, Li C, Spitsbergen JM, Meierjohann S, Schartl M, Gong Z.

J Hepatol. 2012 Feb;56(2):419-25. doi: 10.1016/j.jhep.2011.07.025. Epub 2011 Aug 31.

PMID:
21888874
19.

Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis.

Conner EA, Lemmer ER, Omori M, Wirth PJ, Factor VM, Thorgeirsson SS.

Oncogene. 2000 Oct 19;19(44):5054-62.

20.

AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.

Ho C, Wang C, Mattu S, Destefanis G, Ladu S, Delogu S, Armbruster J, Fan L, Lee SA, Jiang L, Dombrowski F, Evert M, Chen X, Calvisi DF.

Hepatology. 2012 Mar;55(3):833-45. doi: 10.1002/hep.24736. Epub 2011 Dec 19.

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