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Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort study.

Geersing GJ, Erkens PM, Lucassen WA, Büller HR, Cate HT, Hoes AW, Moons KG, Prins MH, Oudega R, van Weert HC, Stoffers HE.

BMJ. 2012 Oct 4;345:e6564. doi: 10.1136/bmj.e6564.


Excluding pulmonary embolism in primary care using the Wells-rule in combination with a point-of care D-dimer test: a scenario analysis.

Lucassen WA, Douma RA, Toll DB, Büller HR, van Weert HC.

BMC Fam Pract. 2010 Sep 13;11:64. doi: 10.1186/1471-2296-11-64.


Qualitative point-of-care D-dimer testing compared with quantitative D-dimer testing in excluding pulmonary embolism in primary care.

Lucassen WA, Erkens PM, Geersing GJ, Büller HR, Moons KG, Stoffers HE, van Weert HC.

J Thromb Haemost. 2015 Jun;13(6):1004-9. doi: 10.1111/jth.12951. Epub 2015 May 9.


Accuracy of the Wells clinical prediction rule for pulmonary embolism in older ambulatory adults.

Schouten HJ, Geersing GJ, Oudega R, van Delden JJ, Moons KG, Koek HL.

J Am Geriatr Soc. 2014 Nov;62(11):2136-41. doi: 10.1111/jgs.13080. Epub 2014 Nov 3.


Alternative diagnoses in patients in whom the GP considered the diagnosis of pulmonary embolism.

Erkens PM, Lucassen WA, Geersing GJ, van Weert HC, Kuijs-Augustijn M, van Heugten M, Rietjens L, ten Cate H, Prins MH, Büller HR, Hoes AW, Moons KG, Oudega R, Stoffers HE.

Fam Pract. 2014 Dec;31(6):670-7. doi: 10.1093/fampra/cmu055. Epub 2014 Sep 12.


Ruling Out Pulmonary Embolism in Primary Care: Comparison of the Diagnostic Performance of "Gestalt" and the Wells Rule.

Hendriksen JM, Lucassen WA, Erkens PM, Stoffers HE, van Weert HC, Büller HR, Hoes AW, Moons KG, Geersing GJ.

Ann Fam Med. 2016 May;14(3):227-34. doi: 10.1370/afm.1930.


Outcomes of high pretest probability patients undergoing d-dimer testing for pulmonary embolism: a pilot study.

Kabrhel C.

J Emerg Med. 2008 Nov;35(4):373-7. doi: 10.1016/j.jemermed.2007.08.070. Epub 2008 Mar 17.


Potential impact of adjusting the threshold of the quantitative D-dimer based on pretest probability of acute pulmonary embolism.

Kabrhel C, Mark Courtney D, Camargo CA Jr, Moore CL, Richman PB, Plewa MC, Nordenholtz KE, Smithline HA, Beam DM, Brown MD, Kline JA.

Acad Emerg Med. 2009 Apr;16(4):325-32. doi: 10.1111/j.1553-2712.2009.00368.x. Epub 2009 Mar 6.


Clinical decision rule and D-dimer have lower clinical utility to exclude pulmonary embolism in cancer patients. Explanations and potential ameliorations.

Douma RA, van Sluis GL, Kamphuisen PW, Söhne M, Leebeek FW, Bossuyt PM, Büller HR.

Thromb Haemost. 2010 Oct;104(4):831-6. doi: 10.1160/TH10-02-0093. Epub 2010 Jul 20.


VIDAS D-dimer in combination with clinical pre-test probability to rule out pulmonary embolism. A systematic review of management outcome studies.

Carrier M, Righini M, Djurabi RK, Huisman MV, Perrier A, Wells PS, Rodger M, Wuillemin WA, Le Gal G.

Thromb Haemost. 2009 May;101(5):886-92. Review.


Different accuracies of rapid enzyme-linked immunosorbent, turbidimetric, and agglutination D-dimer assays for thrombosis exclusion: impact on diagnostic work-ups of outpatients with suspected deep vein thrombosis and pulmonary embolism.

Michiels JJ, Gadisseur A, van der Planken M, Schroyens W, De Maeseneer M, Hermsen JT, Trienekens PH, Hoogsteden H, Pattynama PM.

Semin Thromb Hemost. 2006 Oct;32(7):678-93. Review.


Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer.

Wells PS, Anderson DR, Rodger M, Stiell I, Dreyer JF, Barnes D, Forgie M, Kovacs G, Ward J, Kovacs MJ.

Ann Intern Med. 2001 Jul 17;135(2):98-107.


A simple diagnostic strategy in hospitalized patients with clinically suspected pulmonary embolism.

Kruip MJ, Söhne M, Nijkeuter M, Kwakkel-Van Erp HM, Tick LW, Halkes SJ, Prins MH, Kramer MH, Huisman MV, Büller HR, Leebeek FW; Christopher Study Investigators.

J Intern Med. 2006 Nov;260(5):459-66.


Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis.

Geersing GJ, Zuithoff NP, Kearon C, Anderson DR, Ten Cate-Hoek AJ, Elf JL, Bates SM, Hoes AW, Kraaijenhagen RA, Oudega R, Schutgens RE, Stevens SM, Woller SC, Wells PS, Moons KG.

BMJ. 2014 Mar 10;348:g1340. doi: 10.1136/bmj.g1340. Review.


Pretest probability assessment combined with point-of-care D-dimer testing allows primary care physicians to rule out pulmonary embolism.

Kabrhel C.

Evid Based Med. 2013 Oct;18(5):187-8. doi: 10.1136/eb-2012-101120. Epub 2013 Jan 29. No abstract available.


Validity and clinical utility of the simplified Wells rule for assessing clinical probability for the exclusion of pulmonary embolism.

Douma RA, Gibson NS, Gerdes VE, Büller HR, Wells PS, Perrier A, Le Gal G.

Thromb Haemost. 2009 Jan;101(1):197-200.


Value of D-dimer testing for the exclusion of pulmonary embolism in patients with previous venous thromboembolism.

Le Gal G, Righini M, Roy PM, Sanchez O, Aujesky D, Perrier A, Bounameaux H.

Arch Intern Med. 2006 Jan 23;166(2):176-80.


A simple decision rule including D-dimer to reduce the need for computed tomography scanning in patients with suspected pulmonary embolism.

van Es J, Beenen LF, Douma RA, den Exter PL, Mos IC, Kaasjager HA, Huisman MV, Kamphuisen PW, Middeldorp S, Bossuyt PM.

J Thromb Haemost. 2015 Aug;13(8):1428-35. doi: 10.1111/jth.13011. Epub 2015 Jun 19.

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