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1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.

Durk MR, Chan GN, Campos CR, Peart JC, Chow EC, Lee E, Cannon RE, Bendayan R, Miller DS, Pang KS.

J Neurochem. 2012 Dec;123(6):944-53. doi: 10.1111/jnc.12041. Epub 2012 Nov 1.


Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats.

Durk MR, Fan J, Sun H, Yang Y, Pang H, Pang KS, de Lannoy IA.

Pharm Res. 2015 Mar;32(3):1128-40. doi: 10.1007/s11095-014-1524-y. Epub 2014 Oct 16.


Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line.

Zastre JA, Chan GN, Ronaldson PT, Ramaswamy M, Couraud PO, Romero IA, Weksler B, Bendayan M, Bendayan R.

J Neurosci Res. 2009 Mar;87(4):1023-36. doi: 10.1002/jnr.21898.


Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells.

Lim JC, Kania KD, Wijesuriya H, Chawla S, Sethi JK, Pulaski L, Romero IA, Couraud PO, Weksler BB, Hladky SB, Barrand MA.

J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.


Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123.

Tai LM, Reddy PS, Lopez-Ramirez MA, Davies HA, Male DK, Loughlin AJ, Romero IA.

Brain Res. 2009 Oct 6;1292:14-24. doi: 10.1016/j.brainres.2009.07.039. Epub 2009 Jul 23. Erratum in: Brain Res. 2010 Jan 8;1306:184. Male, A David K [corrected to Male, David K].


Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier.

Emmert D, Campos CR, Ward D, Lu P, Namanja HA, Bohn K, Miller DS, Sharom FJ, Chmielewski J, Hrycyna CA.

ACS Chem Neurosci. 2014 Apr 16;5(4):305-17. doi: 10.1021/cn4002329. Epub 2014 Feb 7.


Up-regulation of transporters and enzymes by the vitamin D receptor ligands, 1alpha,25-dihydroxyvitamin D3 and vitamin D analogs, in the Caco-2 cell monolayer.

Fan J, Liu S, Du Y, Morrison J, Shipman R, Pang KS.

J Pharmacol Exp Ther. 2009 Aug;330(2):389-402. doi: 10.1124/jpet.108.149815. Epub 2009 May 4.


Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells.

Regina A, Koman A, Piciotti M, El Hafny B, Center MS, Bergmann R, Couraud PO, Roux F.

J Neurochem. 1998 Aug;71(2):705-15.


Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells.

Chan GN, Hoque MT, Cummins CL, Bendayan R.

J Neurochem. 2011 Jul;118(2):163-75. doi: 10.1111/j.1471-4159.2011.07288.x. Epub 2011 May 25.


Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice.

Chow EC, Durk MR, Maeng HJ, Pang KS.

Biopharm Drug Dispos. 2013 Oct;34(7):402-16. doi: 10.1002/bdd.1856. Epub 2013 Sep 16. Erratum in: Biopharm Drug Dispos. 2014 Mar;35(2):134.


1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1-40 brain-to-blood efflux and peripheral uptake transport.

Guo YX, He LY, Zhang M, Wang F, Liu F, Peng WX.

Neuroscience. 2016 May 13;322:28-38. doi: 10.1016/j.neuroscience.2016.01.041. Epub 2016 Jan 25.


Induction of P-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells.

Chan GN, Patel R, Cummins CL, Bendayan R.

Antimicrob Agents Chemother. 2013 Sep;57(9):4481-8. doi: 10.1128/AAC.00486-13. Epub 2013 Jul 8.


Modulation of p-glycoprotein function by caveolin-1 phosphorylation.

Barakat S, Demeule M, Pilorget A, Régina A, Gingras D, Baggetto LG, Béliveau R.

J Neurochem. 2007 Apr;101(1):1-8. Epub 2007 Feb 26.


MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier.

Kuhnke D, Jedlitschky G, Grube M, Krohn M, Jucker M, Mosyagin I, Cascorbi I, Walker LC, Kroemer HK, Warzok RW, Vogelgesang S.

Brain Pathol. 2007 Oct;17(4):347-53. Epub 2007 Jul 4.


1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo.

Chow EC, Maeng HJ, Liu S, Khan AA, Groothuis GM, Pang KS.

Biopharm Drug Dispos. 2009 Nov;30(8):457-75. doi: 10.1002/bdd.682.


Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice.

Chow EC, Quach HP, Vieth R, Pang KS.

Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E977-89. doi: 10.1152/ajpendo.00489.2012. Epub 2013 Mar 12.


Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation.

Yousif S, Chaves C, Potin S, Margaill I, Scherrmann JM, Declèves X.

J Neurochem. 2012 Nov;123(4):491-503. doi: 10.1111/j.1471-4159.2012.07890.x. Epub 2012 Sep 3.


The effect of vitamin D3 and ketoconazole combination on VDR-mediated P-gp expression and function in human colon adenocarcinoma cells: implications in drug disposition and resistance.

Kota BP, Allen JD, Roufogalis BD.

Basic Clin Pharmacol Toxicol. 2011 Aug;109(2):97-102. doi: 10.1111/j.1742-7843.2011.00693.x. Epub 2011 May 18.

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