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Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells.

Ohno S, Takanashi M, Sudo K, Ueda S, Ishikawa A, Matsuyama N, Fujita K, Mizutani T, Ohgi T, Ochiya T, Gotoh N, Kuroda M.

Mol Ther. 2013 Jan;21(1):185-91. doi: 10.1038/mt.2012.180.


Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells.

Lee JK, Park SR, Jung BK, Jeon YK, Lee YS, Kim MK, Kim YG, Jang JY, Kim CW.

PLoS One. 2013 Dec 31;8(12):e84256. doi: 10.1371/journal.pone.0084256.


Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line.

Ohshima K, Inoue K, Fujiwara A, Hatakeyama K, Kanto K, Watanabe Y, Muramatsu K, Fukuda Y, Ogura S, Yamaguchi K, Mochizuki T.

PLoS One. 2010 Oct 8;5(10):e13247. doi: 10.1371/journal.pone.0013247.


Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells.

Yang M, Chen J, Su F, Yu B, Su F, Lin L, Liu Y, Huang JD, Song E.

Mol Cancer. 2011 Sep 22;10:117. doi: 10.1186/1476-4598-10-117.


Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner.

Liu ZB, Hou YF, Zhu J, Hu DL, Jin W, Ou ZL, Di GH, Wu J, Shen ZZ, Shao ZM.

Oncogene. 2010 May 20;29(20):2996-3009. doi: 10.1038/onc.2010.70.


Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7.

Webster RJ, Giles KM, Price KJ, Zhang PM, Mattick JS, Leedman PJ.

J Biol Chem. 2009 Feb 27;284(9):5731-41. doi: 10.1074/jbc.M804280200.


Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A1.

Shibahara Y, Miki Y, Onodera Y, Hata S, Chan MS, Yiu CC, Loo TY, Nakamura Y, Akahira J, Ishida T, Abe K, Hirakawa H, Chow LW, Suzuki T, Ouchi N, Sasano H.

J Pathol. 2012 Jul;227(3):357-66. doi: 10.1002/path.4019.


Epidermal growth factor receptor (EGFR)-related protein inhibits multiple members of the EGFR family in colon and breast cancer cells.

Xu H, Yu Y, Marciniak D, Rishi AK, Sarkar FH, Kucuk O, Majumdar AP.

Mol Cancer Ther. 2005 Mar;4(3):435-42.


Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer.

Zhi X, Wang Y, Yu J, Yu J, Zhang L, Yin L, Zhou P.

IUBMB Life. 2012 Nov;64(11):911-20. doi: 10.1002/iub.1086.


MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7.

Kim SJ, Shin JY, Lee KD, Bae YK, Sung KW, Nam SJ, Chun KH.

Breast Cancer Res. 2012 Jan 18;14(1):R14.


Disconnecting the yin and yang relation of epidermal growth factor receptor (EGFR)-mediated delivery: a fully synthetic, EGFR-targeted gene transfer system avoiding receptor activation.

Schäfer A, Pahnke A, Schaffert D, van Weerden WM, de Ridder CM, Rödl W, Vetter A, Spitzweg C, Kraaij R, Wagner E, Ogris M.

Hum Gene Ther. 2011 Dec;22(12):1463-73. doi: 10.1089/hum.2010.231.


A novel taspine derivative, HMQ1611, inhibits breast cancer cell growth via estrogen receptor α and EGF receptor signaling pathways.

Zhan Y, Zhang Y, Liu C, Zhang J, Smith WW, Wang N, Chen Y, Zheng L, He L.

Cancer Prev Res (Phila). 2012 Jun;5(6):864-73. doi: 10.1158/1940-6207.CAPR-11-0575.


Combination therapy with VEGFR2 and EGFR siRNA enhances the antitumor effect of cisplatin in non-small cell lung cancer xenografts.

Chen S, Liu X, Gong W, Yang H, Luo D, Zuo X, Li W, Wu P, Liu L, Xu Q, Ji A.

Oncol Rep. 2013 Jan;29(1):260-8. doi: 10.3892/or.2012.2097.


EGFR over-expression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistance.

Dua R, Zhang J, Nhonthachit P, Penuel E, Petropoulos C, Parry G.

Breast Cancer Res Treat. 2010 Aug;122(3):685-97. doi: 10.1007/s10549-009-0592-x.


Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer.

Bovy N, Blomme B, Frères P, Dederen S, Nivelles O, Lion M, Carnet O, Martial JA, Noël A, Thiry M, Jérusalem G, Josse C, Bours V, Tabruyn SP, Struman I.

Oncotarget. 2015 Apr 30;6(12):10253-66.


Liposomal delivery of MicroRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitor-resistance in lung cancer cells.

Rai K, Takigawa N, Ito S, Kashihara H, Ichihara E, Yasuda T, Shimizu K, Tanimoto M, Kiura K.

Mol Cancer Ther. 2011 Sep;10(9):1720-7. doi: 10.1158/1535-7163.MCT-11-0220.

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