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SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.

Yang H, Zhang W, Pan H, Feldser HG, Lainez E, Miller C, Leung S, Zhong Z, Zhao H, Sweitzer S, Considine T, Riera T, Suri V, White B, Ellis JL, Vlasuk GP, Loh C.

PLoS One. 2012;7(9):e46364. doi: 10.1371/journal.pone.0046364.


Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders.

Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A.

Cell Signal. 2013 Oct;25(10):1939-48. doi: 10.1016/j.cellsig.2013.06.007. Review.


The protective effect of fenofibrate against TNF-α-induced CD40 expression through SIRT1-mediated deacetylation of NF-κB in endothelial cells.

Wang W, Bai L, Qiao H, Lu Y, Yang L, Zhang J, Lin R, Ren F, Zhang J, Ji M.

Inflammation. 2014 Feb;37(1):177-85.


Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts.

Zhu X, Liu Q, Wang M, Liang M, Yang X, Xu X, Zou H, Qiu J.

PLoS One. 2011;6(11):e27081. doi: 10.1371/journal.pone.0027081.


Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes.

Risitano R, Currò M, Cirmi S, Ferlazzo N, Campiglia P, Caccamo D, Ientile R, Navarra M.

PLoS One. 2014 Sep 26;9(9):e107431. doi: 10.1371/journal.pone.0107431.


Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity.

Lei M, Wang JG, Xiao DM, Fan M, Wang DP, Xiong JY, Chen Y, Ding Y, Liu SL.

Eur J Pharmacol. 2012 Jan 15;674(2-3):73-9. doi: 10.1016/j.ejphar.2011.10.015.


Involvement of the p65/RelA subunit of NF-kappaB in TNF-alpha-induced SIRT1 expression in vascular smooth muscle cells.

Zhang HN, Li L, Gao P, Chen HZ, Zhang R, Wei YS, Liu DP, Liang CC.

Biochem Biophys Res Commun. 2010 Jul 2;397(3):569-75. doi: 10.1016/j.bbrc.2010.05.160.


The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway.

Zhang J, Zhang Y, Xiao F, Liu Y, Wang J, Gao H, Rong S, Yao Y, Li J, Xu G.

Biochem Pharmacol. 2016 Feb 1;101:100-11. doi: 10.1016/j.bcp.2015.11.027.


SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells.

Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, Park SK, Lee SY, Han MK, Kim DH, Kim W.

Biochem Biophys Res Commun. 2012 Mar 9;419(2):206-10. doi: 10.1016/j.bbrc.2012.01.148.


Aqueous extract of Vitex trifolia L. (Labiatae) inhibits LPS-dependent regulation of inflammatory mediators in RAW 264.7 macrophages through inhibition of Nuclear Factor kappa B translocation and expression.

Matsui M, Adib-Conquy M, Coste A, Kumar-Roiné S, Pipy B, Laurent D, Pauillac S.

J Ethnopharmacol. 2012 Aug 30;143(1):24-32. doi: 10.1016/j.jep.2012.05.043.


Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines.

Shen Z, Ajmo JM, Rogers CQ, Liang X, Le L, Murr MM, Peng Y, You M.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1047-53. doi: 10.1152/ajpgi.00016.2009.


SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway.

Lin QQ, Yan CF, Lin R, Zhang JY, Wang WR, Yang LN, Zhang KF.

Cytokine. 2012 Nov;60(2):447-55. doi: 10.1016/j.cyto.2012.05.025.


Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress.

Schug TT, Xu Q, Gao H, Peres-da-Silva A, Draper DW, Fessler MB, Purushotham A, Li X.

Mol Cell Biol. 2010 Oct;30(19):4712-21. doi: 10.1128/MCB.00657-10.


Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera.

Lee JH, Jung HS, Giang PM, Jin X, Lee S, Son PT, Lee D, Hong YS, Lee K, Lee JJ.

J Pharmacol Exp Ther. 2006 Jan;316(1):271-8.


Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation.

Choi KC, Jung MG, Lee YH, Yoon JC, Kwon SH, Kang HB, Kim MJ, Cha JH, Kim YJ, Jun WJ, Lee JM, Yoon HG.

Cancer Res. 2009 Jan 15;69(2):583-92. doi: 10.1158/0008-5472.CAN-08-2442.


Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65.

Sharif-Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau MC, Heyd F, Okayama T, Jin J, Rojas ME, Grimes HL, Zeng H, Möröy T.

Mol Cell Biol. 2010 Aug;30(16):3929-42. doi: 10.1128/MCB.00087-10.


Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.

Shinozaki S, Chang K, Sakai M, Shimizu N, Yamada M, Tanaka T, Nakazawa H, Ichinose F, Yamada Y, Ishigami A, Ito H, Ouchi Y, Starr ME, Saito H, Shimokado K, Stamler JS, Kaneki M.

Sci Signal. 2014 Nov 11;7(351):ra106. doi: 10.1126/scisignal.2005375.


Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit.

Ma J, Liang H, Jin HR, Dat NT, Zhang SY, Jiang YZ, Nan JX, Li D, Wu X, Lee JJ, Jin X.

J Pharmacol Sci. 2012;118(4):447-54.

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