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Functional characterization of newly-discovered mutations in human SR-BI.

Chadwick AC, Sahoo D.

PLoS One. 2012;7(9):e45660. doi: 10.1371/journal.pone.0045660. Epub 2012 Sep 21.


SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport.

Kartz GA, Holme RL, Nicholson K, Sahoo D.

Biochemistry. 2014 Oct 7;53(39):6173-82. doi: 10.1021/bi500706x. Epub 2014 Sep 23.


Extracellular disulfide bonds support scavenger receptor class B type I-mediated cholesterol transport.

Papale GA, Hanson PJ, Sahoo D.

Biochemistry. 2011 Jul 19;50(28):6245-54. doi: 10.1021/bi2005625. Epub 2011 Jun 24.


Tryptophan 415 Is Critical for the Cholesterol Transport Functions of Scavenger Receptor BI.

Holme RL, Miller JJ, Nicholson K, Sahoo D.

Biochemistry. 2016 Jan 12;55(1):103-13. doi: 10.1021/acs.biochem.5b00804. Epub 2015 Dec 23.


Lipoprotein lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent of scavenger receptor BI.

Rinninger F, Brundert M, Brosch I, Donarski N, Budzinski RM, Greten H.

J Lipid Res. 2001 Nov;42(11):1740-51.


Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol.

Varban ML, Rinninger F, Wang N, Fairchild-Huntress V, Dunmore JH, Fang Q, Gosselin ML, Dixon KL, Deeds JD, Acton SL, Tall AR, Huszar D.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4619-24.


Separation of lipid transport functions by mutations in the extracellular domain of scavenger receptor class B, type I.

Connelly MA, De La Llera-Moya M, Peng Y, Drazul-Schrader D, Rothblat GH, Williams DL.

J Biol Chem. 2003 Jul 11;278(28):25773-82. Epub 2003 May 2.


Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks.

Chadwick AC, Sahoo D.

Curr Opin Endocrinol Diabetes Obes. 2013 Apr;20(2):124-31. doi: 10.1097/MED.0b013e32835ed575. Review.


Glycine 420 near the C-terminal transmembrane domain of SR-BI is critical for proper delivery and metabolism of high density lipoprotein cholesteryl ester.

Parathath S, Sahoo D, Darlington YF, Peng Y, Collins HL, Rothblat GH, Williams DL, Connelly MA.

J Biol Chem. 2004 Jun 11;279(24):24976-85. Epub 2004 Apr 1.


Analysis of chimeric receptors shows that multiple distinct functional activities of scavenger receptor, class B, type I (SR-BI), are localized to the extracellular receptor domain.

Connelly MA, de la Llera-Moya M, Monzo P, Yancey PG, Drazul D, Stoudt G, Fournier N, Klein SM, Rothblat GH, Williams DL.

Biochemistry. 2001 May 1;40(17):5249-59.


Expression of scavenger receptor BI in COS-7 cells alters cholesterol content and distribution.

Kellner-Weibel G, de La Llera-Moya M, Connelly MA, Stoudt G, Christian AE, Haynes MP, Williams DL, Rothblat GH.

Biochemistry. 2000 Jan 11;39(1):221-9.


Probucol enhances selective uptake of HDL-associated cholesteryl esters in vitro by a scavenger receptor B-I-dependent mechanism.

Rinninger F, Wang N, Ramakrishnan R, Jiang XC, Tall AR.

Arterioscler Thromb Vasc Biol. 1999 May;19(5):1325-32.


Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1.

Lambert G, Chase MB, Dugi K, Bensadoun A, Brewer HB Jr, Santamarina-Fojo S.

J Lipid Res. 1999 Jul;40(7):1294-303.


The role of human and mouse hepatic scavenger receptor class B type I (SR-BI) in the selective uptake of low-density lipoprotein-cholesteryl esters.

Rhainds D, Brodeur M, Lapointe J, Charpentier D, Falstrault L, Brissette L.

Biochemistry. 2003 Jun 24;42(24):7527-38.


Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36.

Parathath S, Connelly MA, Rieger RA, Klein SM, Abumrad NA, De La Llera-Moya M, Iden CR, Rothblat GH, Williams DL.

J Biol Chem. 2004 Oct 1;279(40):41310-8. Epub 2004 Jul 27.


Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface.

de la Llera-Moya M, Rothblat GH, Connelly MA, Kellner-Weibel G, Sakr SW, Phillips MC, Williams DL.

J Lipid Res. 1999 Mar;40(3):575-80.


Hepatic lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent from SR-BI.

Brundert M, Heeren J, Greten H, Rinninger F.

J Lipid Res. 2003 May;44(5):1020-32. Epub 2003 Mar 1.


Roles of scavenger receptor BI and APO A-I in selective uptake of HDL cholesterol by adrenal cells.

Williams DL, Temel RE, Connelly MA.

Endocr Res. 2000 Nov;26(4):639-51. Review.


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