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A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions.

Hirve N, Levytskyy RM, Rigaud S, Guimond DM, Zal T, Sauer K, Tsoukas CD.

PLoS One. 2012;7(9):e45158. doi: 10.1371/journal.pone.0045158.


Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.

Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ.

J Biol Chem. 2000 Jan 21;275(3):2219-30.


Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.

Martínez-Florensa M, García-Blesa A, Yélamos J, Muñoz-Suano A, Domínguez-Villar M, Valdor R, Alonso A, García-Cózar F, Aparicio P, Malissen B, Aguado E.

J Leukoc Biol. 2011 Jan;89(1):63-73. doi: 10.1189/jlb.0509342.


Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.

Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL.

Mol Cell Biol. 2000 Sep;20(18):6945-57.


Positive regulation of Itk PH domain function by soluble IP4.

Huang YH, Grasis JA, Miller AT, Xu R, Soonthornvacharin S, Andreotti AH, Tsoukas CD, Cooke MP, Sauer K.

Science. 2007 May 11;316(5826):886-9.


TCR/CD3-Induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the Src homology 2 domain.

Ching KA, Grasis JA, Tailor P, Kawakami Y, Kawakami T, Tsoukas CD.

J Immunol. 2000 Jul 1;165(1):256-62.


Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.

Hussain A, Mohammad DK, Gustafsson MO, Uslu M, Hamasy A, Nore BF, Mohamed AJ, Smith CI.

J Biol Chem. 2013 Mar 8;288(10):7338-50. doi: 10.1074/jbc.M112.374967.


Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.

Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB.

Biochemistry. 2002 Aug 27;41(34):10732-40.


Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.

Yamasaki S, Nishida K, Hibi M, Sakuma M, Shiina R, Takeuchi A, Ohnishi H, Hirano T, Saito T.

J Biol Chem. 2001 Nov 30;276(48):45175-83.


Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha).

Perez-Villar JJ, O'Day K, Hewgill DH, Nadler SG, Kanner SB.

Int Immunol. 2001 Oct;13(10):1265-74.


Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec.

Boyken SE, Fulton DB, Andreotti AH.

Protein Sci. 2012 Sep;21(9):1288-97. doi: 10.1002/pro.2114.


Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.

Devkota S, Joseph RE, Min L, Bruce Fulton D, Andreotti AH.

J Mol Biol. 2015 Aug 28;427(17):2734-47. doi: 10.1016/j.jmb.2015.04.012.


Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain.

Ching KA, Kawakami Y, Kawakami T, Tsoukas CD.

J Immunol. 1999 Dec 1;163(11):6006-13.


In vivo significance of ITK-SLP-76 interaction in cytokine production.

Grasis JA, Guimond DM, Cam NR, Herman K, Magotti P, Lambris JD, Tsoukas CD.

Mol Cell Biol. 2010 Jul;30(14):3596-609. doi: 10.1128/MCB.01657-09.


The lymphoma-associated fusion tyrosine kinase ITK-SYK requires pleckstrin homology domain-mediated membrane localization for activation and cellular transformation.

Rigby S, Huang Y, Streubel B, Chott A, Du MQ, Turner SD, Bacon CM.

J Biol Chem. 2009 Sep 25;284(39):26871-81. doi: 10.1074/jbc.M109.034272.


Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH.

Sci Signal. 2013 Aug 27;6(290):ra76. doi: 10.1126/scisignal.2004298.

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