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PDGF receptor-α does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway.

Vanarsdall AL, Wisner TW, Lei H, Kazlauskas A, Johnson DC.

PLoS Pathog. 2012 Sep;8(9):e1002905. doi: 10.1371/journal.ppat.1002905. Epub 2012 Sep 13.


Human cytomegalovirus TR strain glycoprotein O acts as a chaperone promoting gH/gL incorporation into virions but is not present in virions.

Ryckman BJ, Chase MC, Johnson DC.

J Virol. 2010 Mar;84(5):2597-609. doi: 10.1128/JVI.02256-09. Epub 2009 Dec 23.


A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells.

Wille PT, Knoche AJ, Nelson JA, Jarvis MA, Johnson DC.

J Virol. 2010 Mar;84(5):2585-96. doi: 10.1128/JVI.02249-09. Epub 2009 Dec 23.


Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.

Wu Y, Prager A, Boos S, Resch M, Brizic I, Mach M, Wildner S, Scrivano L, Adler B.

PLoS Pathog. 2017 Apr 12;13(4):e1006281. doi: 10.1371/journal.ppat.1006281. eCollection 2017 Apr.


Entry of human cytomegalovirus into porcine endothelial cells depends on both the cellular vascular origin and the viral strain.

Taveira A, Ponroy N, Mueller NJ, Millard AL.

Xenotransplantation. 2014 Jul-Aug;21(4):324-40. doi: 10.1111/xen.12097. Epub 2014 Apr 8.


The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes.

Nogalski MT, Chan GC, Stevenson EV, Collins-McMillen DK, Yurochko AD.

PLoS Pathog. 2013;9(7):e1003463. doi: 10.1371/journal.ppat.1003463. Epub 2013 Jul 11.


Loss of the Human Cytomegalovirus US16 Protein Abrogates Virus Entry into Endothelial and Epithelial Cells by Reducing the Virion Content of the Pentamer.

Luganini A, Cavaletto N, Raimondo S, Geuna S, Gribaudo G.

J Virol. 2017 May 12;91(11). pii: e00205-17. doi: 10.1128/JVI.00205-17. Print 2017 Jun 1.


Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection.

Soroceanu L, Akhavan A, Cobbs CS.

Nature. 2008 Sep 18;455(7211):391-5. doi: 10.1038/nature07209. Epub 2008 Aug 13.


Human cytomegalovirus glycoprotein gO complexes with gH/gL, promoting interference with viral entry into human fibroblasts but not entry into epithelial cells.

Vanarsdall AL, Chase MC, Johnson DC.

J Virol. 2011 Nov;85(22):11638-45. doi: 10.1128/JVI.05659-11. Epub 2011 Aug 31.


HCMV gH/gL/UL128-131 interferes with virus entry into epithelial cells: evidence for cell type-specific receptors.

Ryckman BJ, Chase MC, Johnson DC.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14118-23. doi: 10.1073/pnas.0804365105. Epub 2008 Sep 3.


Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells.

Ryckman BJ, Rainish BL, Chase MC, Borton JA, Nelson JA, Jarvis MA, Johnson DC.

J Virol. 2008 Jan;82(1):60-70. Epub 2007 Oct 17.


Scanning Mutagenesis of Human Cytomegalovirus Glycoprotein gH/gL.

Schultz EP, Lanchy JM, Ellerbeck EE, Ryckman BJ.

J Virol. 2015 Dec 9;90(5):2294-305. doi: 10.1128/JVI.01875-15.


CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells.

Vanarsdall AL, Pritchard SR, Wisner TW, Liu J, Jardetzky TS, Johnson DC.

MBio. 2018 May 8;9(3). pii: e00781-18. doi: 10.1128/mBio.00781-18.


Comparative analysis of gO isoforms reveals that strains of human cytomegalovirus differ in the ratio of gH/gL/gO and gH/gL/UL128-131 in the virion envelope.

Zhou M, Yu Q, Wechsler A, Ryckman BJ.

J Virol. 2013 Sep;87(17):9680-90. doi: 10.1128/JVI.01167-13. Epub 2013 Jun 26.


Expression of Oncogenic Alleles Induces Multiple Blocks to Human Cytomegalovirus Infection.

Xu S, Schafer X, Munger J.

J Virol. 2016 Apr 14;90(9):4346-4356. doi: 10.1128/JVI.00179-16. Print 2016 May.


Human cytomegalovirus tropism for endothelial/epithelial cells: scientific background and clinical implications.

Revello MG, Gerna G.

Rev Med Virol. 2010 May;20(3):136-55. doi: 10.1002/rmv.645. Review.


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