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Items: 1 to 20 of 102

1.

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V, Vanhaesebroeck B.

Nat Immunol. 2012 Nov;13(11):1045-1054. doi: 10.1038/ni.2426. Epub 2012 Sep 30. Erratum in: Nat Immunol. 2013 Aug;14(8):877. Berenjeno-Martin, Inma [corrected to Berenjeno, Inma M].

2.

B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells.

Kobayashi Y, Iwata A, Suzuki K, Suto A, Kawashima S, Saito Y, Owada T, Kobayashi M, Watanabe N, Nakajima H.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5121-6. doi: 10.1073/pnas.1222093110. Epub 2013 Mar 11.

3.

Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway.

Zhang S, Yu M, Guo Q, Li R, Li G, Tan S, Li X, Wei Y, Wu M.

Sci Rep. 2015 Nov 3;5:15859. doi: 10.1038/srep15859.

4.

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.

Nature. 2002 Nov 21;420(6913):324-9.

PMID:
12447441
5.

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.

Tanimura N, Saitoh S, Matsumoto F, Akashi-Takamura S, Miyake K.

Biochem Biophys Res Commun. 2008 Mar 28;368(1):94-9. doi: 10.1016/j.bbrc.2008.01.061. Epub 2008 Jan 28.

PMID:
18222170
6.

The Golgi-Associated Plant Pathogenesis-Related Protein GAPR-1 Enhances Type I Interferon Signaling Pathway in Response to Toll-Like Receptor 4.

Zhou Q, Hao L, Huang W, Cai Z.

Inflammation. 2016 Apr;39(2):706-17. doi: 10.1007/s10753-015-0297-8.

PMID:
26678074
7.

IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells.

Strengell M, Lehtonen A, Matikainen S, Julkunen I.

J Leukoc Biol. 2006 Jun;79(6):1279-85. Epub 2006 Mar 21.

PMID:
16551679
8.

The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation.

Ma J, Bang BR, Lu J, Eun SY, Otsuka M, Croft M, Tobias P, Han J, Takeuchi O, Akira S, Karin M, Yagita H, Kang YJ.

Sci Signal. 2013 Oct 1;6(295):ra87. doi: 10.1126/scisignal.2004431.

9.

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.

Horng T, Barton GM, Flavell RA, Medzhitov R.

Nature. 2002 Nov 21;420(6913):329-33.

PMID:
12447442
10.

Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

Andreakos E, Sacre SM, Smith C, Lundberg A, Kiriakidis S, Stonehouse T, Monaco C, Feldmann M, Foxwell BM.

Blood. 2004 Mar 15;103(6):2229-37. Epub 2003 Nov 20.

11.

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.

Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R.

Nat Immunol. 2008 Apr;9(4):361-8. doi: 10.1038/ni1569. Epub 2008 Feb 24.

12.

Endotoxin-induced maturation of MyD88-deficient dendritic cells.

Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S.

J Immunol. 2001 May 1;166(9):5688-94.

13.

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ, Mansell A.

J Biol Chem. 2009 Sep 4;284(36):24192-203. doi: 10.1074/jbc.M109.023044. Epub 2009 Jul 10.

14.

The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling.

Van Acker T, Eyckerman S, Vande Walle L, Gerlo S, Goethals M, Lamkanfi M, Bovijn C, Tavernier J, Peelman F.

J Biol Chem. 2014 Jan 17;289(3):1364-76. doi: 10.1074/jbc.M113.499194. Epub 2013 Dec 2.

15.

Phosphatidylinositol 4-phosphate 5-kinase α facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location.

Nguyen TT, Kim YM, Kim TD, Le OT, Kim JJ, Kang HC, Hasegawa H, Kanaho Y, Jou I, Lee SY.

J Biol Chem. 2013 Feb 22;288(8):5645-59. doi: 10.1074/jbc.M112.410126. Epub 2013 Jan 7.

16.

HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes.

Planès R, Ben Haij N, Leghmari K, Serrero M, BenMohamed L, Bahraoui E.

J Virol. 2016 Jun 10;90(13):5886-98. doi: 10.1128/JVI.00262-16. Print 2016 Jul 1.

18.

TRAM is required for TLR2 endosomal signaling to type I IFN induction.

Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG.

J Immunol. 2014 Dec 15;193(12):6090-102. doi: 10.4049/jimmunol.1401605. Epub 2014 Nov 10.

19.

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.

Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S.

Nat Immunol. 2003 Nov;4(11):1144-50. Epub 2003 Oct 12.

20.

Human cytomegalovirus induces TLR4 signaling components in monocytes altering TIRAP, TRAM and downstream interferon-beta and TNF-alpha expression.

Yew KH, Carpenter C, Duncan RS, Harrison CJ.

PLoS One. 2012;7(9):e44500. doi: 10.1371/journal.pone.0044500. Epub 2012 Sep 7.

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