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Items: 1 to 20 of 112

1.

Folate binding site of flavin-dependent thymidylate synthase.

Koehn EM, Perissinotti LL, Moghram S, Prabhakar A, Lesley SA, Mathews II, Kohen A.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15722-7. Epub 2012 Sep 10.

2.

An unprecedented mechanism of nucleotide methylation in organisms containing thyX.

Mishanina TV, Yu L, Karunaratne K, Mondal D, Corcoran JM, Choi MA, Kohen A.

Science. 2016 Jan 29;351(6272):507-10. doi: 10.1126/science.aad0300.

3.

Flavin-dependent thymidylate synthase: a novel pathway towards thymine.

Koehn EM, Kohen A.

Arch Biochem Biophys. 2010 Jan 1;493(1):96-102. doi: 10.1016/j.abb.2009.07.016. Epub 2009 Jul 28.

4.

Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.

Basta T, Boum Y, Briffotaux J, Becker HF, Lamarre-Jouenne I, Lambry JC, Skouloubris S, Liebl U, Graille M, van Tilbeurgh H, Myllykallio H.

Open Biol. 2012 Oct;2(10):120120. doi: 10.1098/rsob.120120.

5.

Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.

Griffin J, Roshick C, Iliffe-Lee E, McClarty G.

J Biol Chem. 2005 Feb 18;280(7):5456-67. Epub 2004 Dec 8.

6.

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.

Koehn EM, Fleischmann T, Conrad JA, Palfey BA, Lesley SA, Mathews II, Kohen A.

Nature. 2009 Apr 16;458(7240):919-23. doi: 10.1038/nature07973.

7.

Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria.

Leduc D, Escartin F, Nijhout HF, Reed MC, Liebl U, Skouloubris S, Myllykallio H.

J Bacteriol. 2007 Dec;189(23):8537-45. Epub 2007 Sep 21.

8.

Crystal structure of a flavin-dependent thymidylate synthase from Helicobacter pylori strain 26695.

Zhang X, Zhang J, Guo G, Mao X, Hu Y, Zou Q.

Protein Pept Lett. 2012 Nov;19(11):1225-30.

PMID:
22512654
9.
10.
11.

Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein.

Mathews II, Deacon AM, Canaves JM, McMullan D, Lesley SA, Agarwalla S, Kuhn P.

Structure. 2003 Jun;11(6):677-90.

13.

Oxidase activity of a flavin-dependent thymidylate synthase.

Wang Z, Chernyshev A, Koehn EM, Manuel TD, Lesley SA, Kohen A.

FEBS J. 2009 May;276(10):2801-10. doi: 10.1111/j.1742-4658.2009.07003.x.

14.

Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: calorimetric and crystallographic analysis of the K48Q mutant.

Arvizu-Flores AA, Sugich-Miranda R, Arreola R, Garcia-Orozco KD, Velazquez-Contreras EF, Montfort WR, Maley F, Sotelo-Mundo RR.

Int J Biochem Cell Biol. 2008;40(10):2206-17. doi: 10.1016/j.biocel.2008.02.025. Epub 2008 Mar 6.

15.

Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase.

Mishanina TV, Koehn EM, Conrad JA, Palfey BA, Lesley SA, Kohen A.

J Am Chem Soc. 2012 Mar 7;134(9):4442-8. doi: 10.1021/ja2120822. Epub 2012 Feb 24.

16.

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.

Catalano A, Luciani R, Carocci A, Cortesi D, Pozzi C, Borsari C, Ferrari S, Mangani S.

Eur J Med Chem. 2016 Nov 10;123:649-64. doi: 10.1016/j.ejmech.2016.07.066. Epub 2016 Jul 29.

PMID:
27517810
17.

Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution.

Sampathkumar P, Turley S, Ulmer JE, Rhie HG, Sibley CH, Hol WG.

J Mol Biol. 2005 Oct 7;352(5):1091-104.

PMID:
16139296
18.

Mechanistic studies of a flavin-dependent thymidylate synthase.

Agrawal N, Lesley SA, Kuhn P, Kohen A.

Biochemistry. 2004 Aug 17;43(32):10295-301.

PMID:
15301527
19.

Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.

Ulmer JE, Boum Y, Thouvenel CD, Myllykallio H, Sibley CH.

J Bacteriol. 2008 Mar;190(6):2056-64. doi: 10.1128/JB.01094-07. Epub 2008 Jan 11.

20.

Biochemical characterization of two thymidylate synthases in Corynebacterium glutamicum NCHU 87078.

Kan SC, Liu JS, Hu HY, Chang CM, Lin WD, Wang WC, Hsu WH.

Biochim Biophys Acta. 2010 Sep;1804(9):1751-9. doi: 10.1016/j.bbapap.2010.05.006. Epub 2010 May 31.

PMID:
20595007

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