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Items: 1 to 20 of 98

1.

Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.

Vashistha H, Singhal PC, Malhotra A, Husain M, Mathieson P, Saleem MA, Kuriakose C, Seshan S, Wilk A, Delvalle L, Peruzzi F, Giorgio M, Pelicci PG, Smithies O, Kim HS, Kakoki M, Reiss K, Meggs LG.

Am J Physiol Renal Physiol. 2012 Dec 15;303(12):F1629-40. doi: 10.1152/ajprenal.00246.2012. Epub 2012 Sep 26.

2.

Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.

Kakoki M, Sullivan KA, Backus C, Hayes JM, Oh SS, Hua K, Gasim AM, Tomita H, Grant R, Nossov SB, Kim HS, Jennette JC, Feldman EL, Smithies O.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.

3.

Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors.

Kakoki M, Kizer CM, Yi X, Takahashi N, Kim HS, Bagnell CR, Edgell CJ, Maeda N, Jennette JC, Smithies O.

J Clin Invest. 2006 May;116(5):1302-9. Epub 2006 Apr 6.

4.

Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis.

Malhotra A, Vashistha H, Yadav VS, Dube MG, Kalra SP, Abdellatif M, Meggs LG.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H380-8. doi: 10.1152/ajpheart.00225.2008. Epub 2008 Dec 5.

5.

Diabetic nephropathy: lessons from the mouse.

Vashistha H, Meggs L.

Ochsner J. 2013 Spring;13(1):140-6.

6.

Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

Camici GG, Schiavoni M, Francia P, Bachschmid M, Martin-Padura I, Hersberger M, Tanner FC, Pelicci P, Volpe M, Anversa P, Lüscher TF, Cosentino F.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5217-22. Epub 2007 Mar 14.

7.

Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes.

Paneni F, Mocharla P, Akhmedov A, Costantino S, Osto E, Volpe M, Lüscher TF, Cosentino F.

Circ Res. 2012 Jul 20;111(3):278-89. doi: 10.1161/CIRCRESAHA.112.266593. Epub 2012 Jun 12.

8.

The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

Natalicchio A, Tortosa F, Labarbuta R, Biondi G, Marrano N, Carchia E, Leonardini A, Cignarelli A, Bugliani M, Marchetti P, Fadini GP, Giorgio M, Avogaro A, Perrini S, Laviola L, Giorgino F.

Diabetologia. 2015 Jun;58(6):1260-71. doi: 10.1007/s00125-015-3563-2. Epub 2015 Mar 26. Erratum in: Diabetologia. 2015 Nov;58(11):2682.

PMID:
25810038
9.

Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice.

Gurley SB, Mach CL, Stegbauer J, Yang J, Snow KP, Hu A, Meyer TW, Coffman TM.

Am J Physiol Renal Physiol. 2010 Mar;298(3):F788-95. doi: 10.1152/ajprenal.90515.2008. Epub 2009 Dec 30.

10.

Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc.

Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci PG, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann KG, Esmon CT, Madhusudhan T, Nawroth PP, Isermann B.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):648-53. doi: 10.1073/pnas.1218667110. Epub 2012 Dec 24.

11.

Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.

Vikram A, Kim YR, Kumar S, Naqvi A, Hoffman TA, Kumar A, Miller FJ Jr, Kim CS, Irani K.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2301-9. doi: 10.1161/ATVBAHA.114.304338. Epub 2014 Aug 21.

12.

p53-p66(shc)/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma.

Yang J, Qiu B, Li X, Zhang H, Liu W.

Toxicol Lett. 2015 Nov 4;238(3):1-10. doi: 10.1016/j.toxlet.2015.07.016. Epub 2015 Jul 26.

PMID:
26222667
13.

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging.

Gambino V, De Michele G, Venezia O, Migliaccio P, Dall'Olio V, Bernard L, Minardi SP, Della Fazia MA, Bartoli D, Servillo G, Alcalay M, Luzi L, Giorgio M, Scrable H, Pelicci PG, Migliaccio E.

Aging Cell. 2013 Jun;12(3):435-45. doi: 10.1111/acel.12060. Epub 2013 Mar 27.

14.

The Ins2Akita mouse as a model of early retinal complications in diabetes.

Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2210-8.

PMID:
15914643
15.

Bradykinin inhibits high glucose- and growth factor-induced collagen synthesis in mesangial cells through the B2-kinin receptor.

Blaes N, Pécher C, Mehrenberger M, Cellier E, Praddaude F, Chevalier J, Tack I, Couture R, Girolami JP.

Am J Physiol Renal Physiol. 2012 Jul 15;303(2):F293-303. doi: 10.1152/ajprenal.00437.2011. Epub 2012 May 9.

16.

p66Shc-generated oxidative signal promotes fat accumulation.

Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, Pelicci PG, Giorgio M.

J Biol Chem. 2008 Dec 5;283(49):34283-93. doi: 10.1074/jbc.M804362200. Epub 2008 Oct 6.

17.

Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways.

Akhmedov A, Montecucco F, Braunersreuther V, Camici GG, Jakob P, Reiner MF, Glanzmann M, Burger F, Paneni F, Galan K, Pelli G, Vuilleumier N, Belin A, Vallée JP, Mach F, Lüscher TF.

Eur Heart J. 2015 Feb 21;36(8):516-26a. doi: 10.1093/eurheartj/ehu400. Epub 2014 Oct 21.

PMID:
25336219
18.

Propofol protects against angiotensin II-induced mouse hippocampal HT22 cells apoptosis via inhibition of p66Shc mitochondrial translocation.

Zhu M, Chen J, Wen M, Sun Z, Sun X, Wang J, Miao C.

Neuromolecular Med. 2014 Dec;16(4):772-81. doi: 10.1007/s12017-014-8326-6. Epub 2014 Aug 24.

PMID:
25151272
19.

p66(Shc) protein, oxidative stress, and cardiovascular complications of diabetes: the missing link.

Francia P, Cosentino F, Schiavoni M, Huang Y, Perna E, Camici GG, Lüscher TF, Volpe M.

J Mol Med (Berl). 2009 Sep;87(9):885-91. doi: 10.1007/s00109-009-0499-3. Epub 2009 Jul 10. Review.

PMID:
19590843
20.

p66(Shc)-induced redox changes drive endothelial insulin resistance.

Paneni F, Costantino S, Cosentino F.

Atherosclerosis. 2014 Oct;236(2):426-9. doi: 10.1016/j.atherosclerosis.2014.07.027. Epub 2014 Aug 5.

PMID:
25150941

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