Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 79

1.

4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.

El Bakali J, Gilleron P, Body-Malapel M, Mansouri R, Muccioli GG, Djouina M, Barczyk A, Klupsch F, Andrzejak V, Lipka E, Furman C, Lambert DM, Chavatte P, Desreumaux P, Millet R.

J Med Chem. 2012 Oct 25;55(20):8948-52. doi: 10.1021/jm3008568. Epub 2012 Oct 12.

PMID:
23017078
2.

Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists.

Aghazadeh Tabrizi M, Baraldi PG, Saponaro G, Moorman AR, Romagnoli R, Preti D, Baraldi S, Ruggiero E, Tintori C, Tuccinardi T, Vincenzi F, Borea PA, Varani K.

J Med Chem. 2013 Jun 13;56(11):4482-96. doi: 10.1021/jm400182t. Epub 2013 Jun 4.

PMID:
23697626
3.

4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series.

El Bakali J, Muccioli GG, Renault N, Pradal D, Body-Malapel M, Djouina M, Hamtiaux L, Andrzejak V, Desreumaux P, Chavatte P, Lambert DM, Millet R.

J Med Chem. 2010 Nov 25;53(22):7918-31. doi: 10.1021/jm100286k. Epub 2010 Oct 27.

PMID:
20979417
4.

7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2) cannabinoid receptor ligands: structural investigations around a novel class of full agonists.

Baraldi PG, Saponaro G, Moorman AR, Romagnoli R, Preti D, Baraldi S, Ruggiero E, Varani K, Targa M, Vincenzi F, Borea PA, Aghazadeh Tabrizi M.

J Med Chem. 2012 Jul 26;55(14):6608-23. doi: 10.1021/jm300763w. Epub 2012 Jul 11.

PMID:
22738271
5.

A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo.

Lunn CA, Fine JS, Rojas-Triana A, Jackson JV, Fan X, Kung TT, Gonsiorek W, Schwarz MA, Lavey B, Kozlowski JA, Narula SK, Lundell DJ, Hipkin RW, Bober LA.

J Pharmacol Exp Ther. 2006 Feb;316(2):780-8. Epub 2005 Oct 28.

PMID:
16258021
6.

Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality.

Stern E, Muccioli GG, Bosier B, Hamtiaux L, Millet R, Poupaert JH, Hénichart JP, Depreux P, Goossens JF, Lambert DM.

J Med Chem. 2007 Nov 1;50(22):5471-84. Epub 2007 Oct 4.

PMID:
17915849
7.

Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.

Tourteau A, Leleu-Chavain N, Body-Malapel M, Andrzejak V, Barczyk A, Djouina M, Rigo B, Desreumaux P, Chavatte P, Millet R.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1322-6. doi: 10.1016/j.bmcl.2014.01.056. Epub 2014 Jan 28.

PMID:
24508127
8.

Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice.

Cluny NL, Keenan CM, Duncan M, Fox A, Lutz B, Sharkey KA.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):973-80. doi: 10.1124/jpet.110.169946. Epub 2010 Jun 22.

PMID:
20571060
9.

Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.

Chu GH, Saeui CT, Worm K, Weaver DG, Goodman AJ, Broadrup RL, Cassel JA, DeHaven RN, LaBuda CJ, Koblish M, Brogdon B, Smith S, Le Bourdonnec B, Dolle RE.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5931-5. doi: 10.1016/j.bmcl.2009.08.063. Epub 2009 Aug 21.

PMID:
19736007
10.

1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.

Muccioli GG, Wouters J, Scriba GK, Poppitz W, Poupaert JH, Lambert DM.

J Med Chem. 2005 Nov 17;48(23):7486-90.

PMID:
16279809
11.

Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists.

Worm K, Weaver DG, Green RC, Saeui CT, Dulay DM, Barker WM, Cassel JA, Stabley GJ, DeHaven RN, LaBuda CJ, Koblish M, Brogdon BL, Smith SA, Dolle RE.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5004-8. doi: 10.1016/j.bmcl.2009.07.057. Epub 2009 Jul 12.

PMID:
19646869
12.

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.

Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T.

J Med Chem. 2006 Mar 23;49(6):2022-7.

PMID:
16539390
13.

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.

Tourteau A, Andrzejak V, Body-Malapel M, Lemaire L, Lemoine A, Mansouri R, Djouina M, Renault N, El Bakali J, Desreumaux P, Muccioli GG, Lambert DM, Chavatte P, Rigo B, Leleu-Chavain N, Millet R.

Bioorg Med Chem. 2013 Sep 1;21(17):5383-94. doi: 10.1016/j.bmc.2013.06.010. Epub 2013 Jun 15.

PMID:
23849204
14.

Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow.

Markt P, Feldmann C, Rollinger JM, Raduner S, Schuster D, Kirchmair J, Distinto S, Spitzer GM, Wolber G, Laggner C, Altmann KH, Langer T, Gertsch J.

J Med Chem. 2009 Jan 22;52(2):369-78. doi: 10.1021/jm801044g.

PMID:
19143566
15.

2-Amino-5-aryl-pyridines as selective CB2 agonists: synthesis and investigation of structure-activity relationships.

Gleave RJ, Beswick PJ, Brown AJ, Giblin GM, Haslam CP, Livermore D, Moses A, Nicholson NH, Page LW, Slingsby B, Swarbrick ME.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6578-81. doi: 10.1016/j.bmcl.2009.10.041. Epub 2009 Oct 13.

PMID:
19864133
16.

Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo.

Pasquini S, Botta L, Semeraro T, Mugnaini C, Ligresti A, Palazzo E, Maione S, Di Marzo V, Corelli F.

J Med Chem. 2008 Aug 28;51(16):5075-84. doi: 10.1021/jm800552f. Epub 2008 Aug 5.

PMID:
18680276
18.

Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.

Frost JM, Dart MJ, Tietje KR, Garrison TR, Grayson GK, Daza AV, El-Kouhen OF, Miller LN, Li L, Yao BB, Hsieh GC, Pai M, Zhu CZ, Chandran P, Meyer MD.

J Med Chem. 2008 Mar 27;51(6):1904-12. doi: 10.1021/jm7011613. Epub 2008 Feb 27.

PMID:
18311894
19.

Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice.

Pasquini S, De Rosa M, Pedani V, Mugnaini C, Guida F, Luongo L, De Chiaro M, Maione S, Dragoni S, Frosini M, Ligresti A, Di Marzo V, Corelli F.

J Med Chem. 2011 Aug 11;54(15):5444-53. doi: 10.1021/jm200476p. Epub 2011 Jul 6.

PMID:
21702498
20.

Synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid CB2 receptor.

Reux B, Nevalainen T, Raitio KH, Koskinen AM.

Bioorg Med Chem. 2009 Jul 1;17(13):4441-7. doi: 10.1016/j.bmc.2009.05.013. Epub 2009 May 12.

PMID:
19477133

Supplemental Content

Support Center