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Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells.

Schito L, Rey S, Tafani M, Zhang H, Wong CC, Russo A, Russo MA, Semenza GL.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):E2707-16. doi: 10.1073/pnas.1214019109. Epub 2012 Sep 10.


Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma.

Kodama M, Kitadai Y, Sumida T, Ohnishi M, Ohara E, Tanaka M, Shinagawa K, Tanaka S, Yasui W, Chayama K.

Cancer Sci. 2010 Sep;101(9):1984-9. doi: 10.1111/j.1349-7006.2010.01639.x.


Expression of platelet-derived growth factor receptor β is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis.

Miyazaki H, Yoshimatsu Y, Akatsu Y, Mishima K, Fukayama M, Watabe T, Miyazono K.

Cancer Sci. 2014 Sep;105(9):1116-23. doi: 10.1111/cas.12476. Epub 2014 Sep 11.


HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells.

Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H, Semenza GL.

Oncotarget. 2015 May 20;6(14):11768-78.


PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.

Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L.

Clin Cancer Res. 2011 Jun 1;17(11):3638-48. doi: 10.1158/1078-0432.CCR-10-2456. Epub 2011 Apr 1.


Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer.

Schoppmann SF, Fenzl A, Schindl M, Bachleitner-Hofmann T, Nagy K, Gnant M, Horvat R, Jakesz R, Birner P.

Breast Cancer Res Treat. 2006 Sep;99(2):135-41. Epub 2006 Mar 23.


Imatinib as a key inhibitor of the platelet-derived growth factor receptor mediated expression of cell surface heparan sulfate proteoglycans and functional properties of breast cancer cells.

Malavaki CJ, Roussidis AE, Gialeli C, Kletsas D, Tsegenidis T, Theocharis AD, Tzanakakis GN, Karamanos NK.

FEBS J. 2013 May;280(10):2477-89. doi: 10.1111/febs.12163. Epub 2013 Feb 27.


Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.

Veith C, Zakrzewicz D, Dahal BK, Bálint Z, Murmann K, Wygrecka M, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G.

Thromb Haemost. 2014 Dec;112(6):1288-303. doi: 10.1160/TH13-12-1031. Epub 2014 Sep 18.


β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression.

Shenoy SK, Han S, Zhao YL, Hara MR, Oliver T, Cao Y, Dewhirst MW.

Oncogene. 2012 Jan 19;31(3):282-92. doi: 10.1038/onc.2011.238. Epub 2011 Jun 20.


PDGFRbeta and HIF-1alpha inhibition with imatinib and radioimmunotherapy of experimental prostate cancer.

Kimura Y, Inoue K, Abe M, Nearman J, Baranowska-Kortylewicz J.

Cancer Biol Ther. 2007 Nov;6(11):1763-72. Epub 2007 Aug 12.


Platelet-derived growth factor-B (PDGF-B) induced by hypoxia promotes the survival of pulmonary arterial endothelial cells through the PI3K/Akt/Stat3 pathway.

Li L, Xu M, Li X, Lv C, Zhang X, Yu H, Zhang M, Fu Y, Meng H, Zhou J.

Cell Physiol Biochem. 2015;35(2):441-51. doi: 10.1159/000369709. Epub 2015 Jan 15.


Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice.

Lev DC, Kim SJ, Onn A, Stone V, Nam DH, Yazici S, Fidler IJ, Price JE.

Clin Cancer Res. 2005 Jan 1;11(1):306-14.


Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer.

Bendinelli P, Maroni P, Matteucci E, Luzzati A, Perrucchini G, Desiderio MA.

Eur J Cancer. 2013 Jul;49(11):2608-18. doi: 10.1016/j.ejca.2013.03.002. Epub 2013 Apr 6.


Role of hypoxia-inducible factors in breast cancer metastasis.

Gilkes DM, Semenza GL.

Future Oncol. 2013 Nov;9(11):1623-36. doi: 10.2217/fon.13.92. Review.


PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.

Cao R, Björndahl MA, Religa P, Clasper S, Garvin S, Galter D, Meister B, Ikomi F, Tritsaris K, Dissing S, Ohhashi T, Jackson DG, Cao Y.

Cancer Cell. 2004 Oct;6(4):333-45. Erratum in: Cancer Cell. 2006 Mar;9(3):239.


Hypoxia-inducible factor-1α (HIF-1α) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions.

Yi T, Papadopoulos E, Hagner PR, Wagner G.

J Biol Chem. 2013 Jun 28;288(26):18732-42. doi: 10.1074/jbc.M113.471466. Epub 2013 May 10.


Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer.

Bos R, van Diest PJ, de Jong JS, van der Groep P, van der Valk P, van der Wall E.

Histopathology. 2005 Jan;46(1):31-6.


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