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Items: 1 to 20 of 111

1.

Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression.

Imai Y, Boyle S, Varela GM, Caron E, Yin X, Dhir R, Dhir R, Graham MJ, Ahima RS.

Physiol Genomics. 2012 Nov 15;44(22):1125-31. doi: 10.1152/physiolgenomics.00045.2012.

2.

Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide.

Imai Y, Varela GM, Jackson MB, Graham MJ, Crooke RM, Ahima RS.

Gastroenterology. 2007 May;132(5):1947-54.

PMID:
17484887
3.

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.

Yu XX, Murray SF, Pandey SK, Booten SL, Bao D, Song XZ, Kelly S, Chen S, McKay R, Monia BP, Bhanot S.

Hepatology. 2005 Aug;42(2):362-71.

PMID:
16001399
4.

Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice.

Carr RM, Peralta G, Yin X, Ahima RS.

PLoS One. 2014 May 15;9(5):e97118. doi: 10.1371/journal.pone.0097118.

5.

Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice.

Carr RM, Patel RT, Rao V, Dhir R, Graham MJ, Crooke RM, Ahima RS.

Am J Physiol Regul Integr Comp Physiol. 2012 Apr 15;302(8):R996-1003. doi: 10.1152/ajpregu.00177.2011.

6.

Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine.

Frank DN, Bales ES, Monks J, Jackman MJ, MacLean PS, Ir D, Robertson CE, Orlicky DJ, McManaman JL.

PLoS One. 2015 Jul 6;10(7):e0131944. doi: 10.1371/journal.pone.0131944.

7.

Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice.

Soufi N, Hall AM, Chen Z, Yoshino J, Collier SL, Mathews JC, Brunt EM, Albert CJ, Graham MJ, Ford DA, Finck BN.

J Biol Chem. 2014 Oct 24;289(43):30177-88. doi: 10.1074/jbc.M114.595850.

8.

Inhibition of ADRP prevents diet-induced insulin resistance.

Varela GM, Antwi DA, Dhir R, Yin X, Singhal NS, Graham MJ, Crooke RM, Ahima RS.

Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G621-8. doi: 10.1152/ajpgi.90204.2008.

9.

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.

Popov VB, Jornayvaz FR, Akgul EO, Kanda S, Jurczak MJ, Zhang D, Abudukadier A, Majumdar SK, Guigni B, Petersen KF, Manchem VP, Bhanot S, Shulman GI, Samuel VT.

FASEB J. 2016 Mar;30(3):1207-17. doi: 10.1096/fj.15-271999.

10.
11.

Reversion of steatosis by SREBP-1c antisense oligonucleotide did not improve hepatic insulin action in diet-induced obesity mice.

Vitto MF, Luz G, Luciano TF, Marques SO, Souza DR, Pinho RA, Lira FS, Cintra DE, De Souza CT.

Horm Metab Res. 2012 Nov;44(12):885-90. doi: 10.1055/s-0032-1321819.

PMID:
22932913
12.

Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression.

Yu XX, Pandey SK, Booten SL, Murray SF, Monia BP, Bhanot S.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E530-9. doi: 10.1152/ajpendo.00350.2007.

13.
14.

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity.

Bosma M, Sparks LM, Hooiveld GJ, Jorgensen JA, Houten SM, Schrauwen P, Kersten S, Hesselink MK.

Biochim Biophys Acta. 2013 Apr;1831(4):844-52. doi: 10.1016/j.bbalip.2013.01.007.

PMID:
23353597
15.

Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mice.

Kopec AK, Joshi N, Towery KL, Kassel KM, Sullivan BP, Flick MJ, Luyendyk JP.

J Pharmacol Exp Ther. 2014 Nov;351(2):288-97. doi: 10.1124/jpet.114.218545.

16.

Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels.

Bosma M, Hesselink MK, Sparks LM, Timmers S, Ferraz MJ, Mattijssen F, van Beurden D, Schaart G, de Baets MH, Verheyen FK, Kersten S, Schrauwen P.

Diabetes. 2012 Nov;61(11):2679-90. doi: 10.2337/db11-1402.

17.

Delayed liver regeneration after partial hepatectomy in adipose differentiation related protein-null mice.

Kohjima M, Tsai TH, Tackett BC, Thevananther S, Li L, Chang BH, Chan L.

J Hepatol. 2013 Dec;59(6):1246-54. doi: 10.1016/j.jhep.2013.07.025.

18.

Effect of dietary monosodium glutamate on HFCS-induced hepatic steatosis: expression profiles in the liver and visceral fat.

Collison KS, Maqbool ZM, Inglis AL, Makhoul NJ, Saleh SM, Bakheet RH, Al-Johi MA, Al-Rabiah RK, Zaidi MZ, Al-Mohanna FA.

Obesity (Silver Spring). 2010 Jun;18(6):1122-34. doi: 10.1038/oby.2009.502.

19.

Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice.

Yu XX, Watts LM, Manchem VP, Chakravarty K, Monia BP, McCaleb ML, Bhanot S.

PLoS One. 2013 Jul 29;8(7):e66923. doi: 10.1371/journal.pone.0066923.

20.

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.

Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, Guebre-Egziabher F, Jurczak MJ, Kahn M, Guigni BA, Serr J, Hankin J, Murphy RC, Cline GW, Bhanot S, Manchem VP, Brown JM, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1869-74. doi: 10.1073/pnas.1219456110.

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