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The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage.

Reynolds P, Anderson JA, Harper JV, Hill MA, Botchway SW, Parker AW, O'Neill P.

Nucleic Acids Res. 2012 Nov;40(21):10821-31. doi: 10.1093/nar/gks879. Epub 2012 Sep 24.


DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.

Yu Y, Mahaney BL, Yano K, Ye R, Fang S, Douglas P, Chen DJ, Lees-Miller SP.

DNA Repair (Amst). 2008 Oct 1;7(10):1680-92. doi: 10.1016/j.dnarep.2008.06.015. Epub 2008 Aug 3.


Laser-induced radiation microbeam technology and simultaneous real-time fluorescence imaging in live cells.

Botchway SW, Reynolds P, Parker AW, O'Neill P.

Methods Enzymol. 2012;504:3-28. doi: 10.1016/B978-0-12-391857-4.00001-X. Review.


Modeling damage complexity-dependent non-homologous end-joining repair pathway.

Li Y, Reynolds P, O'Neill P, Cucinotta FA.

PLoS One. 2014 Feb 10;9(2):e85816. doi: 10.1371/journal.pone.0085816. eCollection 2014.


Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate.

Castore R, Hughes C, Debeaux A, Sun J, Zeng C, Wang SY, Tatchell K, Shi R, Lee KJ, Chen DJ, Harrison L.

Mutagenesis. 2011 Nov;26(6):795-803. doi: 10.1093/mutage/ger049. Epub 2011 Aug 2.


DNA-PKcs and ATM co-regulate DNA double-strand break repair.

Shrivastav M, Miller CA, De Haro LP, Durant ST, Chen BP, Chen DJ, Nickoloff JA.

DNA Repair (Amst). 2009 Aug 6;8(8):920-9. doi: 10.1016/j.dnarep.2009.05.006. Epub 2009 Jun 16.


DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

Drouet J, Delteil C, Lefrançois J, Concannon P, Salles B, Calsou P.

J Biol Chem. 2005 Feb 25;280(8):7060-9. Epub 2004 Oct 31.


Biochemical evidence for Ku-independent backup pathways of NHEJ.

Wang H, Perrault AR, Takeda Y, Qin W, Wang H, Iliakis G.

Nucleic Acids Res. 2003 Sep 15;31(18):5377-88.


Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks.

Schulte-Uentrop L, El-Awady RA, Schliecker L, Willers H, Dahm-Daphi J.

Nucleic Acids Res. 2008 May;36(8):2561-9. doi: 10.1093/nar/gkn094. Epub 2008 Mar 10.


TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.

Heo J, Li J, Summerlin M, Hays A, Katyal S, McKinnon PJ, Nitiss KC, Nitiss JL, Hanakahi LA.

DNA Repair (Amst). 2015 Jun;30:28-37. doi: 10.1016/j.dnarep.2015.03.003. Epub 2015 Mar 17.


Mechanisms of DNA double strand break repair and chromosome aberration formation.

Iliakis G, Wang H, Perrault AR, Boecker W, Rosidi B, Windhofer F, Wu W, Guan J, Terzoudi G, Pantelias G.

Cytogenet Genome Res. 2004;104(1-4):14-20. Review.


Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks.

Tomimatsu N, Tahimic CG, Otsuki A, Burma S, Fukuhara A, Sato K, Shiota G, Oshimura M, Chen DJ, Kurimasa A.

J Biol Chem. 2007 Apr 6;282(14):10138-45. Epub 2007 Feb 1.


The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.

Goodarzi AA, Jeggo P, Lobrich M.

DNA Repair (Amst). 2010 Dec 10;9(12):1273-82. doi: 10.1016/j.dnarep.2010.09.013. Epub 2010 Oct 30. Review.


Ku recruits XLF to DNA double-strand breaks.

Yano K, Morotomi-Yano K, Wang SY, Uematsu N, Lee KJ, Asaithamby A, Weterings E, Chen DJ.

EMBO Rep. 2008 Jan;9(1):91-6. Epub 2007 Dec 7.


Repair of a minimal DNA double-strand break by NHEJ requires DNA-PKcs and is controlled by the ATM/ATR checkpoint.

Kühne C, Tjörnhammar ML, Pongor S, Banks L, Simoncsits A.

Nucleic Acids Res. 2003 Dec 15;31(24):7227-37.


DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP.

DNA Repair (Amst). 2005 Aug 15;4(9):1006-18.


APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation.

Macrae CJ, McCulloch RD, Ylanko J, Durocher D, Koch CA.

DNA Repair (Amst). 2008 Feb 1;7(2):292-302.


Suppression of DNA-PKcs and Ku80 individually and in combination: Different effects of radiobiology in HeLa cells.

Zhuang L, Cao Y, Xiong H, Gao Q, Cao Z, Liu F, Qiu H, Yu S, Huang X.

Int J Oncol. 2011 Aug;39(2):443-51. doi: 10.3892/ijo.2011.1041. Epub 2011 May 13.


Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.

Wang H, Zeng ZC, Perrault AR, Cheng X, Qin W, Iliakis G.

Nucleic Acids Res. 2001 Apr 15;29(8):1653-60.


BCLAF1 is a radiation-induced H2AX-interacting partner involved in γH2AX-mediated regulation of apoptosis and DNA repair.

Lee YY, Yu YB, Gunawardena HP, Xie L, Chen X.

Cell Death Dis. 2012 Jul 26;3:e359. doi: 10.1038/cddis.2012.76.

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