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DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants.

Ziyab AH, Karmaus W, Holloway JW, Zhang H, Ewart S, Arshad SH.

J Eur Acad Dermatol Venereol. 2013 Mar;27(3):e420-3. doi: 10.1111/jdv.12000. Epub 2012 Sep 25.


Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: results from the Isle of Wight birth cohort.

Ziyab AH, Karmaus W, Zhang H, Holloway JW, Steck SE, Ewart S, Arshad SH.

Clin Exp Allergy. 2014 Sep;44(9):1170-8. doi: 10.1111/cea.12321.


Association of filaggrin variants with asthma and rhinitis: is eczema or allergic sensitization status an effect modifier?

Ziyab AH, Karmaus W, Zhang H, Holloway JW, Steck SE, Ewart S, Arshad SH.

Int Arch Allergy Immunol. 2014;164(4):308-18. doi: 10.1159/000365990. Epub 2014 Sep 23.


Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age.

Ziyab AH, Karmaus W, Yousefi M, Ewart S, Schauberger E, Holloway JW, Zhang H, Arshad SH.

PLoS One. 2012;7(3):e32721. doi: 10.1371/journal.pone.0032721. Epub 2012 Mar 5.


Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.

Bisgaard H, Simpson A, Palmer CN, Bønnelykke K, McLean I, Mukhopadhyay S, Pipper CB, Halkjaer LB, Lipworth B, Hankinson J, Woodcock A, Custovic A.

PLoS Med. 2008 Jun 24;5(6):e131. doi: 10.1371/journal.pmed.0050131.


Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children.

Brown SJ, Relton CL, Liao H, Zhao Y, Sandilands A, McLean WH, Cordell HJ, Reynolds NJ.

Br J Dermatol. 2009 Oct;161(4):884-9. doi: 10.1111/j.1365-2133.2009.09339.x. Epub 2009 Jun 11.


Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age.

Flohr C, England K, Radulovic S, McLean WH, Campbel LE, Barker J, Perkin M, Lack G.

Br J Dermatol. 2010 Dec;163(6):1333-6.


Carriers of filaggrin gene (FLG) mutations avoid professional exposure to irritants in adulthood.

Bandier J, Ross-Hansen K, Carlsen BC, Menné T, Linneberg A, Stender S, Szecsi PB, Meldgaard M, Thyssen JP, Johansen JD.

Contact Dermatitis. 2013 Dec;69(6):355-62. doi: 10.1111/cod.12097. Epub 2013 Jun 28.


Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth.

Bønnelykke K, Pipper CB, Tavendale R, Palmer CN, Bisgaard H.

Pediatr Allergy Immunol. 2010 Sep;21(6):954-61. doi: 10.1111/j.1399-3038.2010.01073.x. Epub 2010 Jun 21.


Filaggrin mutations, atopic eczema, hay fever, and asthma in children.

Weidinger S, O'Sullivan M, Illig T, Baurecht H, Depner M, Rodriguez E, Ruether A, Klopp N, Vogelberg C, Weiland SK, McLean WH, von Mutius E, Irvine AD, Kabesch M.

J Allergy Clin Immunol. 2008 May;121(5):1203-1209.e1. doi: 10.1016/j.jaci.2008.02.014. Epub 2008 Apr 8.


Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease.

Van Limbergen J, Russell RK, Nimmo ER, Zhao Y, Liao H, Drummond HE, Davies G, Gillett PM, McGrogan P, Bisset WM, Mahdi G, Wilson DC, Brown SJ, McLean WH, Satsangi J.

Inflamm Bowel Dis. 2009 Oct;15(10):1492-8. doi: 10.1002/ibd.20926.


Filaggrin null mutations and childhood atopic eczema: a population-based case-control study.

Brown SJ, Relton CL, Liao H, Zhao Y, Sandilands A, Wilson IJ, Burn J, Reynolds NJ, McLean WH, Cordell HJ.

J Allergy Clin Immunol. 2008 Apr;121(4):940-46.e3. doi: 10.1016/j.jaci.2008.01.013. Epub 2008 Mar 4.


Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure.

Schuttelaar ML, Kerkhof M, Jonkman MF, Koppelman GH, Brunekreef B, de Jongste JC, Wijga A, McLean WH, Postma DS.

Allergy. 2009 Dec;64(12):1758-65. doi: 10.1111/j.1398-9995.2009.02080.x. Epub 2009 Oct 14.


Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.

Weidinger S, Baurecht H, Wagenpfeil S, Henderson J, Novak N, Sandilands A, Chen H, Rodriguez E, O'Regan GM, Watson R, Liao H, Zhao Y, Barker JN, Allen M, Reynolds N, Meggitt S, Northstone K, Smith GD, Strobl C, Stahl C, Kneib T, Klopp N, Bieber T, Behrendt H, Palmer CN, Wichmann HE, Ring J, Illig T, McLean WH, Irvine AD.

J Allergy Clin Immunol. 2008 Sep;122(3):560-8.e4. doi: 10.1016/j.jaci.2008.05.050. Erratum in: J Allergy Clin Immunol. 2008 Nov;122(5):976.


The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study.

Henderson J, Northstone K, Lee SP, Liao H, Zhao Y, Pembrey M, Mukhopadhyay S, Smith GD, Palmer CN, McLean WH, Irvine AD.

J Allergy Clin Immunol. 2008 Apr;121(4):872-7.e9. doi: 10.1016/j.jaci.2008.01.026. Epub 2008 Mar 5.


Genotype-phenotype associations in filaggrin loss-of-function mutation carriers.

Landeck L, Visser M, Kezic S, John SM.

Contact Dermatitis. 2013 Mar;68(3):149-55. doi: 10.1111/j.1600-0536.2012.02171.x.


Elder siblings enhance the effect of filaggrin mutations on childhood eczema: results from the 2 birth cohort studies LISAplus and GINIplus.

Cramer C, Link E, Horster M, Koletzko S, Bauer CP, Berdel D, von Berg A, Lehmann I, Herbarth O, Borte M, Schaaf B, Behrendt H, Chen CM, Sausenthaler S, Illig T, Wichmann HE, Heinrich J, Krämer U; LISAplus Study Group and the GINIplus Study Group.

J Allergy Clin Immunol. 2010 Jun;125(6):1254-1260.e5. doi: 10.1016/j.jaci.2010.03.036.


No remarkable differences in rates of sensitization to common type I and IV allergens between FLG loss-of-function mutation carriers and wild-type subjects.

Landeck L, Visser M, Skudlik C, Brans R, Kezic S, John SM.

Contact Dermatitis. 2014 Jan;70(1):27-34. doi: 10.1111/cod.12109. Epub 2013 Jul 15.


Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence.

Venkataraman D, Soto-Ramírez N, Kurukulaaratchy RJ, Holloway JW, Karmaus W, Ewart SL, Arshad SH, Erlewyn-Lajeunesse M.

J Allergy Clin Immunol. 2014 Oct;134(4):876-882.e4. doi: 10.1016/j.jaci.2014.07.033. Epub 2014 Aug 28.

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