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The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction.

Mizutori Y, Chen CR, McLachlan SM, Rapoport B.

Mol Endocrinol. 2008 May;22(5):1171-82. doi: 10.1210/me.2007-0407. Epub 2008 Jan 24.


Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation.

Chen CR, McLachlan SM, Rapoport B.

Endocrinology. 2010 Apr;151(4):1940-7. doi: 10.1210/en.2009-1430. Epub 2010 Feb 24.


Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological function.

Hamidi S, Chen CR, Mizutori-Sasai Y, McLachlan SM, Rapoport B.

Mol Endocrinol. 2011 Jan;25(1):184-94. doi: 10.1210/me.2010-0401. Epub 2010 Nov 24.


Evidence that the thyroid-stimulating hormone (TSH) receptor transmembrane domain influences kinetics of TSH binding to the receptor ectodomain.

Chen CR, McLachlan SM, Rapoport B.

J Biol Chem. 2011 Feb 25;286(8):6219-24. doi: 10.1074/jbc.M110.211003. Epub 2010 Dec 28.


Identification of novel TSH interaction sites by systematic binding analysis of the TSHR hinge region.

Mueller S, Szkudlinski MW, Schaarschmidt J, G√ľnther R, Paschke R, Jaeschke H.

Endocrinology. 2011 Aug;152(8):3268-78. doi: 10.1210/en.2011-0153. Epub 2011 May 31.


Novel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptor.

Chen CR, Salazar LM, McLachlan SM, Rapoport B.

PLoS One. 2012;7(2):e31973. doi: 10.1371/journal.pone.0031973. Epub 2012 Feb 16.


Evidence that the C terminus of the A subunit suppresses thyrotropin receptor constitutive activity.

Chen CR, Chazenbalk GD, McLachlan SM, Rapoport B.

Endocrinology. 2003 Sep;144(9):3821-7.


Antibody protection reveals extended epitopes on the human TSH receptor.

Latif R, Teixeira A, Michalek K, Ali MR, Schlesinger M, Baliram R, Morshed SA, Davies TF.

PLoS One. 2012;7(9):e44669. doi: 10.1371/journal.pone.0044669. Epub 2012 Sep 5.


The hinge region of the TSH receptor stabilizes ligand binding and determines different signaling profiles of human and bovine TSH.

Jaeschke H, Schaarschmidt J, G√ľnther R, Mueller S.

Endocrinology. 2011 Oct;152(10):3986-96. doi: 10.1210/en.2011-1389. Epub 2011 Aug 16.


Defining structural and functional dimensions of the extracellular thyrotropin receptor region.

Kleinau G, Mueller S, Jaeschke H, Grzesik P, Neumann S, Diehl A, Paschke R, Krause G.

J Biol Chem. 2011 Jun 24;286(25):22622-31. doi: 10.1074/jbc.M110.211193. Epub 2011 Apr 27.


The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.

Mueller S, Kleinau G, Szkudlinski MW, Jaeschke H, Krause G, Paschke R.

J Biol Chem. 2009 Jun 12;284(24):16317-24. doi: 10.1074/jbc.M109.005710. Epub 2009 Apr 22.


Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure.

Hamidi S, Chen CR, McLachlan SM, Rapoport B.

Thyroid. 2011 Sep;21(9):1013-20. doi: 10.1089/thy.2011.0147. Epub 2011 Aug 11. Erratum in: Thyroid. 2011 Dec;21(12):1405.


Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.

Schaarschmidt J, Huth S, Meier R, Paschke R, Jaeschke H.

PLoS One. 2014 Oct 23;9(10):e111570. doi: 10.1371/journal.pone.0111570. eCollection 2014.

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