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Transcriptome-wide analysis of exosome targets.

Schneider C, Kudla G, Wlotzka W, Tuck A, Tollervey D.

Mol Cell. 2012 Nov 9;48(3):422-33. doi: 10.1016/j.molcel.2012.08.013. Epub 2012 Sep 20.


Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex.

Delan-Forino C, Schneider C, Tollervey D.

PLoS Genet. 2017 Mar 29;13(3):e1006699. doi: 10.1371/journal.pgen.1006699. eCollection 2017 Mar.


Extensive degradation of RNA precursors by the exosome in wild-type cells.

Gudipati RK, Xu Z, Lebreton A, Séraphin B, Steinmetz LM, Jacquier A, Libri D.

Mol Cell. 2012 Nov 9;48(3):409-21. doi: 10.1016/j.molcel.2012.08.018. Epub 2012 Sep 20.


Rrp47 functions in RNA surveillance and stable RNA processing when divorced from the exoribonuclease and exosome-binding domains of Rrp6.

Garland W, Feigenbutz M, Turner M, Mitchell P.

RNA. 2013 Dec;19(12):1659-68. doi: 10.1261/rna.039388.113. Epub 2013 Oct 8.


The exosome component Rrp6 is required for RNA polymerase II termination at specific targets of the Nrd1-Nab3 pathway.

Fox MJ, Gao H, Smith-Kinnaman WR, Liu Y, Mosley AL.

PLoS Genet. 2015 Feb 13;11(2):e1004999. doi: 10.1371/journal.pgen.1004999. eCollection 2015.


The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro.

Drazkowska K, Tomecki R, Stodus K, Kowalska K, Czarnocki-Cieciura M, Dziembowski A.

Nucleic Acids Res. 2013 Apr 1;41(6):3845-58. doi: 10.1093/nar/gkt060. Epub 2013 Feb 12.


The exosome cofactor Rrp47 is critical for the stability and normal expression of its associated exoribonuclease Rrp6 in Saccharomyces cerevisiae.

Feigenbutz M, Garland W, Turner M, Mitchell P.

PLoS One. 2013 Nov 5;8(11):e80752. doi: 10.1371/journal.pone.0080752. eCollection 2013.


Proteomic analysis of yeast mutant RNA exosome complexes.

Lourenço RF, Leme AF, Oliveira CC.

J Proteome Res. 2013 Dec 6;12(12):5912-22. doi: 10.1021/pr400972x. Epub 2013 Nov 26.


Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product.

Reis FP, Barbas A, Klauer-King AA, Tsanova B, Schaeffer D, López-Viñas E, Gómez-Puertas P, van Hoof A, Arraiano CM.

PLoS One. 2013 Nov 12;8(11):e76504. doi: 10.1371/journal.pone.0076504. eCollection 2013. Erratum in: PLoS One. 2015;10(8):e0136810.


Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.

Wasmuth EV, Lima CD.

Mol Cell. 2012 Oct 12;48(1):133-44. doi: 10.1016/j.molcel.2012.07.012. Epub 2012 Aug 16.


Nab3 facilitates the function of the TRAMP complex in RNA processing via recruitment of Rrp6 independent of Nrd1.

Fasken MB, Laribee RN, Corbett AH.

PLoS Genet. 2015 Mar 16;11(3):e1005044. doi: 10.1371/journal.pgen.1005044. eCollection 2015 Mar.


A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.

Milligan L, Decourty L, Saveanu C, Rappsilber J, Ceulemans H, Jacquier A, Tollervey D.

Mol Cell Biol. 2008 Sep;28(17):5446-57. doi: 10.1128/MCB.00463-08. Epub 2008 Jun 30.


Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing.

Wang HW, Wang J, Ding F, Callahan K, Bratkowski MA, Butler JS, Nogales E, Ke A.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16844-9. Epub 2007 Oct 17.


The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome.

Schneider C, Leung E, Brown J, Tollervey D.

Nucleic Acids Res. 2009 Mar;37(4):1127-40. doi: 10.1093/nar/gkn1020. Epub 2009 Jan 7.


Distinct 18S rRNA precursors are targets of the exosome complex, the exoribonuclease RRP6L2 and the terminal nucleotidyltransferase TRL in Arabidopsis thaliana.

Sikorski PJ, Zuber H, Philippe L, Sement FM, Canaday J, Kufel J, Gagliardi D, Lange H.

Plant J. 2015 Sep;83(6):991-1004. doi: 10.1111/tpj.12943.


The RNA polymerase II C-terminal domain-interacting domain of yeast Nrd1 contributes to the choice of termination pathway and couples to RNA processing by the nuclear exosome.

Heo DH, Yoo I, Kong J, Lidschreiber M, Mayer A, Choi BY, Hahn Y, Cramer P, Buratowski S, Kim M.

J Biol Chem. 2013 Dec 20;288(51):36676-90. doi: 10.1074/jbc.M113.508267. Epub 2013 Nov 6.


Activities of human RRP6 and structure of the human RRP6 catalytic domain.

Januszyk K, Liu Q, Lima CD.

RNA. 2011 Aug;17(8):1566-77. doi: 10.1261/rna.2763111. Epub 2011 Jun 24.


Assembly of the yeast exoribonuclease Rrp6 with its associated cofactor Rrp47 occurs in the nucleus and is critical for the controlled expression of Rrp47.

Feigenbutz M, Jones R, Besong TM, Harding SE, Mitchell P.

J Biol Chem. 2013 May 31;288(22):15959-70. doi: 10.1074/jbc.M112.445759. Epub 2013 Apr 11.

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