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Items: 1 to 20 of 103

1.

Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency.

Bouchecareilh M, Hutt DM, Szajner P, Flotte TR, Balch WE.

J Biol Chem. 2012 Nov 2;287(45):38265-78. doi: 10.1074/jbc.M112.404707. Epub 2012 Sep 20.

2.

[Alpha-1-antitrypsin deficiency].

Bouchecareilh M.

Med Sci (Paris). 2014 Oct;30(10):889-95. doi: 10.1051/medsci/20143010016. Epub 2014 Oct 14. Review. French.

3.
4.

Proteostasis strategies for restoring alpha1-antitrypsin deficiency.

Bouchecareilh M, Conkright JJ, Balch WE.

Proc Am Thorac Soc. 2010 Nov;7(6):415-22. doi: 10.1513/pats.201001-016AW. Review.

5.

Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency.

Ordóñez A, Snapp EL, Tan L, Miranda E, Marciniak SJ, Lomas DA.

Hepatology. 2013 May;57(5):2049-60. doi: 10.1002/hep.26173. Epub 2013 Mar 14.

6.

Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization.

Berthelier V, Harris JB, Estenson KN, Baudry J.

PLoS One. 2015 May 11;10(5):e0126256. doi: 10.1371/journal.pone.0126256. eCollection 2015.

7.

SAHA enhances Proteostasis of epilepsy-associated α1(A322D)β2γ2 GABA(A) receptors.

Di XJ, Han DY, Wang YJ, Chance MR, Mu TW.

Chem Biol. 2013 Dec 19;20(12):1456-68. doi: 10.1016/j.chembiol.2013.09.020. Epub 2013 Nov 7.

8.

Intrapleural administration of an AAVrh.10 vector coding for human α1-antitrypsin for the treatment of α1-antitrypsin deficiency.

Chiuchiolo MJ, Kaminsky SM, Sondhi D, Hackett NR, Rosenberg JB, Frenk EZ, Hwang Y, Van de Graaf BG, Hutt JA, Wang G, Benson J, Crystal RG.

Hum Gene Ther Clin Dev. 2013 Dec;24(4):161-73. doi: 10.1089/humc.2013.168.

PMID:
24191907
9.

A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.

Long OS, Benson JA, Kwak JH, Luke CJ, Gosai SJ, O'Reilly LP, Wang Y, Li J, Vetica AC, Miedel MT, Stolz DB, Watkins SC, Züchner S, Perlmutter DH, Silverman GA, Pak SC.

Hum Mol Genet. 2014 Oct 1;23(19):5109-22. doi: 10.1093/hmg/ddu235. Epub 2014 May 16.

10.

Histone deacetylase inhibition is cytotoxic to oligodendrocyte precursor cells in vitro and in vivo.

Dincman TA, Beare JE, Ohri SS, Gallo V, Hetman M, Whittemore SR.

Int J Dev Neurosci. 2016 Nov;54:53-61. doi: 10.1016/j.ijdevneu.2016.08.006. Epub 2016 Aug 29.

PMID:
27587342
11.

ANCA-associated vasculitis is linked to carriage of the Z allele of α₁ antitrypsin and its polymers.

Morris H, Morgan MD, Wood AM, Smith SW, Ekeowa UI, Herrmann K, Holle JU, Guillevin L, Lomas DA, Perez J, Pusey CD, Salama AD, Stockley R, Wieczorek S, McKnight AJ, Maxwell AP, Miranda E, Williams J, Savage CO, Harper L.

Ann Rheum Dis. 2011 Oct;70(10):1851-6. doi: 10.1136/ard.2011.153569. Epub 2011 Aug 5.

PMID:
21821620
12.

Suberoylanilide hydroxamic acid (SAHA)-induced dynamics of a human histone deacetylase protein interaction network.

Sardiu ME, Smith KT, Groppe BD, Gilmore JM, Saraf A, Egidy R, Peak A, Seidel CW, Florens L, Workman JL, Washburn MP.

Mol Cell Proteomics. 2014 Nov;13(11):3114-25. doi: 10.1074/mcp.M113.037127. Epub 2014 Jul 29.

13.

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.

Yamasaki M, Sendall TJ, Pearce MC, Whisstock JC, Huntington JA.

EMBO Rep. 2011 Sep 30;12(10):1011-7. doi: 10.1038/embor.2011.171.

14.

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo.

Chiu HW, Yeh YL, Wang YC, Huang WJ, Chen YA, Chiou YS, Ho SY, Lin P, Wang YJ.

PLoS One. 2013 Oct 10;8(10):e76340. doi: 10.1371/journal.pone.0076340. eCollection 2013.

15.

Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication.

Sato A, Saito Y, Sugiyama K, Sakasegawa N, Muramatsu T, Fukuda S, Yoneya M, Kimura M, Ebinuma H, Hibi T, Ikeda M, Kato N, Saito H.

J Cell Biochem. 2013 Sep;114(9):1987-96. doi: 10.1002/jcb.24541.

PMID:
23519646
16.

In silico modification of suberoylanilide hydroxamic acid (SAHA) as potential inhibitor for class II histone deacetylase (HDAC).

Tambunan US, Bramantya N, Parikesit AA.

BMC Bioinformatics. 2011;12 Suppl 13:S23. doi: 10.1186/1471-2105-12-S13-S23. Epub 2011 Nov 30.

17.

Inhibition of intracellular degradation increases secretion of a mutant form of alpha1-antitrypsin associated with profound deficiency.

Novoradovskaya N, Lee J, Yu ZX, Ferrans VJ, Brantly M.

J Clin Invest. 1998 Jun 15;101(12):2693-701.

18.

Alpha1-antitrypsin deficiency: biological answers to clinical questions.

Coakley RJ, Taggart C, O'Neill S, McElvaney NG.

Am J Med Sci. 2001 Jan;321(1):33-41. Review.

PMID:
11202478
19.

Proteostasis: a new therapeutic paradigm for pulmonary disease.

Bouchecareilh M, Balch WE.

Proc Am Thorac Soc. 2011 May;8(2):189-95. doi: 10.1513/pats.201008-055MS.

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