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Expression and role of epithelial cell adhesion molecule in dysplastic nodule and hepatocellular carcinoma.

Bae JS, Noh SJ, Jang KY, Park HS, Chung MJ, Park CK, Moon WS.

Int J Oncol. 2012 Dec;41(6):2150-8. doi: 10.3892/ijo.2012.1631. Epub 2012 Sep 19.


EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features.

Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, Jia H, Ye Q, Qin LX, Wauthier E, Reid LM, Minato H, Honda M, Kaneko S, Tang ZY, Wang XW.

Gastroenterology. 2009 Mar;136(3):1012-24. doi: 10.1053/j.gastro.2008.12.004. Epub 2008 Dec 6.


Angiogenesis and clinicopathologic characteristics in different hepatocellular carcinoma subtypes defined by EpCAM and α-fetoprotein expression status.

Shan YF, Huang YL, Xie YK, Tan YH, Chen BC, Zhou MT, Shi HQ, Yu ZP, Song QT, Zhang QY.

Med Oncol. 2011 Dec;28(4):1012-6. doi: 10.1007/s12032-010-9600-6. Epub 2010 Jun 23.


EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma.

Terris B, Cavard C, Perret C.

J Hepatol. 2010 Feb;52(2):280-1. doi: 10.1016/j.jhep.2009.10.026. Epub 2009 Nov 10.


Perinodular ductular reaction/epithelial cell adhesion molecule loss in small hepatic nodules.

Zhang Q, Zhang CS, Xin Q, Ma Z, Liu GQ, Liu BB, Wang FM, Gao YT, Du Z.

World J Gastroenterol. 2014 Aug 21;20(31):10908-15. doi: 10.3748/wjg.v20.i31.10908.


Identification of microRNAs specific for epithelial cell adhesion molecule-positive tumor cells in hepatocellular carcinoma.

Ji J, Zheng X, Forgues M, Yamashita T, Wauthier EL, Reid LM, Wen X, Song Y, Wei JS, Khan J, Thorgeirsson SS, Wang XW.

Hepatology. 2015 Sep;62(3):829-40. doi: 10.1002/hep.27886. Epub 2015 Jun 30.


Cancer stem cell markers correlate with early recurrence and survival in hepatocellular carcinoma.

Guo Z, Li LQ, Jiang JH, Ou C, Zeng LX, Xiang BD.

World J Gastroenterol. 2014 Feb 28;20(8):2098-106. doi: 10.3748/wjg.v20.i8.2098.


Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection.

Sun YF, Xu Y, Yang XR, Guo W, Zhang X, Qiu SJ, Shi RY, Hu B, Zhou J, Fan J.

Hepatology. 2013 Apr;57(4):1458-68. doi: 10.1002/hep.26151. Epub 2013 Mar 4.


Expression of stemness markers (CD133 and EpCAM) in prognostication of hepatocellular carcinoma.

Chan AW, Tong JH, Chan SL, Lai PB, To KF.

Histopathology. 2014 Jun;64(7):935-50. doi: 10.1111/his.12342. Epub 2014 Feb 7.


Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma.

Fan QM, Jing YY, Yu GF, Kou XR, Ye F, Gao L, Li R, Zhao QD, Yang Y, Lu ZH, Wei LX.

Cancer Lett. 2014 Oct 1;352(2):160-8. doi: 10.1016/j.canlet.2014.05.008. Epub 2014 Jun 2.


EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma.

Yamashita T, Forgues M, Wang W, Kim JW, Ye Q, Jia H, Budhu A, Zanetti KA, Chen Y, Qin LX, Tang ZY, Wang XW.

Cancer Res. 2008 Mar 1;68(5):1451-61. doi: 10.1158/0008-5472.CAN-07-6013.


Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma.

Yamashita T, Honda M, Nakamoto Y, Baba M, Nio K, Hara Y, Zeng SS, Hayashi T, Kondo M, Takatori H, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Wang XW, Kaneko S.

Hepatology. 2013 Apr;57(4):1484-97. doi: 10.1002/hep.26168. Epub 2013 Jan 18.


Telomere length, TERT and shelterin complex proteins in hepatocellular carcinomas expressing "stemness"-related markers.

Kim H, Yoo JE, Cho JY, Oh BK, Yoon YS, Han HS, Lee HS, Jang JJ, Jeong SH, Kim JW, Park YN.

J Hepatol. 2013 Oct;59(4):746-52. doi: 10.1016/j.jhep.2013.05.011. Epub 2013 May 14.


Epithelial cell adhesion molecule-positive human hepatic neoplastic cells: development of combined hepatocellular-cholangiocarcinoma in mice.

Ogasawara S, Akiba J, Nakayama M, Nakashima O, Torimura T, Yano H.

J Gastroenterol Hepatol. 2015 Feb;30(2):413-20. doi: 10.1111/jgh.12692.


Expression of EpCAM increases in the hepatitis B related and the treatment-resistant hepatocellular carcinoma.

Kimura O, Kondo Y, Kogure T, Kakazu E, Ninomiya M, Iwata T, Morosawa T, Shimosegawa T.

Biomed Res Int. 2014;2014:172913. doi: 10.1155/2014/172913. Epub 2014 Feb 17.


Nuclear EpICD expression and its role in hepatocellular carcinoma.

Park SY, Bae JS, Cha EJ, Chu HH, Sohn JS, Moon WS.

Oncol Rep. 2016 Jul;36(1):197-204. doi: 10.3892/or.2016.4789. Epub 2016 May 6.


The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma.

Zeng SS, Yamashita T, Kondo M, Nio K, Hayashi T, Hara Y, Nomura Y, Yoshida M, Hayashi T, Oishi N, Ikeda H, Honda M, Kaneko S.

J Hepatol. 2014 Jan;60(1):127-34. doi: 10.1016/j.jhep.2013.08.024. Epub 2013 Sep 6.


Presence of EpCAM-positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma.

Schulze K, Gasch C, Staufer K, Nashan B, Lohse AW, Pantel K, Riethdorf S, Wege H.

Int J Cancer. 2013 Nov;133(9):2165-71. doi: 10.1002/ijc.28230. Epub 2013 Jun 11.


Expression of epithelial cell adhesion molecule associated with elevated ductular reactions in hepatocellar carcinoma.

Xu M, Qian G, Xie F, Shi C, Yan L, Yu L, Zheng T, Wei L, Yang J.

Clin Res Hepatol Gastroenterol. 2014 Dec;38(6):699-705. doi: 10.1016/j.clinre.2014.04.015. Epub 2014 Jun 9.


Expressions of hypoxia-inducible factor-1 and epithelial cell adhesion molecule are linked with aggressive local recurrence of hepatocellular carcinoma after radiofrequency ablation therapy.

Yamada S, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Arakawa Y, Kanamoto M, Iwahashi S, Saito Y, Takasu C, Ishikawa D, Shimada M.

Ann Surg Oncol. 2014 Jun;21 Suppl 3:S436-42. doi: 10.1245/s10434-014-3575-z. Epub 2014 Feb 25.


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