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The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites.

Della-Maria J, Hegde ML, McNeill DR, Matsumoto Y, Tsai MS, Ellenberger T, Wilson DM 3rd, Mitra S, Tomkinson AE.

J Biol Chem. 2012 Nov 9;287(46):39233-44. doi: 10.1074/jbc.M112.369975. Epub 2012 Sep 19.


Independent mechanisms of stimulation of polynucleotide kinase/phosphatase by phosphorylated and non-phosphorylated XRCC1.

Lu M, Mani RS, Karimi-Busheri F, Fanta M, Wang H, Litchfeld DW, Weinfeld M.

Nucleic Acids Res. 2010 Jan;38(2):510-21. doi: 10.1093/nar/gkp1023. Epub 2009 Nov 12.


Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.

Zolner AE, Abdou I, Ye R, Mani RS, Fanta M, Yu Y, Douglas P, Tahbaz N, Fang S, Dobbs T, Wang C, Morrice N, Hendzel MJ, Weinfeld M, Lees-Miller SP.

Nucleic Acids Res. 2011 Nov;39(21):9224-37. doi: 10.1093/nar/gkr647. Epub 2011 Aug 8.


Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains.

Cherry AL, Nott TJ, Kelly G, Rulten SL, Caldecott KW, Smerdon SJ.

DNA Repair (Amst). 2015 Nov;35:116-25. doi: 10.1016/j.dnarep.2015.10.002. Epub 2015 Oct 23.


Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.

Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M.

J Biol Chem. 2010 Nov 26;285(48):37619-29. doi: 10.1074/jbc.M109.058719. Epub 2010 Sep 17.


Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK.

Ali AA, Jukes RM, Pearl LH, Oliver AW.

Nucleic Acids Res. 2009 Apr;37(5):1701-12. doi: 10.1093/nar/gkn1086. Epub 2009 Jan 20.


DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.

Parsons JL, Dianova II, Allinson SL, Dianov GL.

Biochemistry. 2005 Aug 9;44(31):10613-9.


Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.

Freschauf GK, Mani RS, Mereniuk TR, Fanta M, Virgen CA, Dianov GL, Grassot JM, Hall DG, Weinfeld M.

J Biol Chem. 2010 Jan 22;285(4):2351-60. doi: 10.1074/jbc.M109.055764. Epub 2009 Nov 23.


The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1.

Hanssen-Bauer A, Solvang-Garten K, Gilljam KM, Torseth K, Wilson DM 3rd, Akbari M, Otterlei M.

DNA Repair (Amst). 2012 Apr 1;11(4):357-66. doi: 10.1016/j.dnarep.2012.01.001. Epub 2012 Jan 26.


XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.

Dianova II, Sleeth KM, Allinson SL, Parsons JL, Breslin C, Caldecott KW, Dianov GL.

Nucleic Acids Res. 2004 May 11;32(8):2550-5. Print 2004.


The structural basis of XRCC1-mediated DNA repair.

London RE.

DNA Repair (Amst). 2015 Jun;30:90-103. doi: 10.1016/j.dnarep.2015.02.005. Epub 2015 Feb 16. Review.


DNA 3'-phosphatase activity is critical for rapid global rates of single-strand break repair following oxidative stress.

Breslin C, Caldecott KW.

Mol Cell Biol. 2009 Sep;29(17):4653-62. doi: 10.1128/MCB.00677-09. Epub 2009 Jun 22.


Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3.

Gao R, Liu Y, Silva-Fernandes A, Fang X, Paulucci-Holthauzen A, Chatterjee A, Zhang HL, Matsuura T, Choudhary S, Ashizawa T, Koeppen AH, Maciel P, Hazra TK, Sarkar PS.

PLoS Genet. 2015 Jan 15;11(1):e1004834. doi: 10.1371/journal.pgen.1004834. eCollection 2015 Jan.


The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response.

Li M, Lu LY, Yang CY, Wang S, Yu X.

Genes Dev. 2013 Aug 15;27(16):1752-68. doi: 10.1101/gad.226357.113.


XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair.

Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW.

Cell. 2001 Jan 12;104(1):107-17.


Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.

Weinfeld M, Mani RS, Abdou I, Aceytuno RD, Glover JN.

Trends Biochem Sci. 2011 May;36(5):262-71. doi: 10.1016/j.tibs.2011.01.006. Epub 2011 Feb 25. Review.


DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair.

Abdou I, Poirier GG, Hendzel MJ, Weinfeld M.

Nucleic Acids Res. 2015 Jan;43(2):875-92. doi: 10.1093/nar/gku1307. Epub 2014 Dec 24.


A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair.

Taylor RM, Moore DJ, Whitehouse J, Johnson P, Caldecott KW.

Mol Cell Biol. 2000 Jan;20(2):735-40.


Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1.

Iftner T, Elbel M, Schopp B, Hiller T, Loizou JI, Caldecott KW, Stubenrauch F.

EMBO J. 2002 Sep 2;21(17):4741-8.

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