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Items: 1 to 20 of 98

1.

Cell polarisation and the immunological synapse.

Angus KL, Griffiths GM.

Curr Opin Cell Biol. 2013 Feb;25(1):85-91. doi: 10.1016/j.ceb.2012.08.013. Epub 2012 Sep 16. Review.

2.

Centrosome polarization delivers secretory granules to the immunological synapse.

Stinchcombe JC, Majorovits E, Bossi G, Fuller S, Griffiths GM.

Nature. 2006 Sep 28;443(7110):462-5. Erratum in: Nature. 2006 Nov 9;444(7116):236.

PMID:
17006514
3.

Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.

de Saint Basile G, Ménasché G, Fischer A.

Nat Rev Immunol. 2010 Aug;10(8):568-79. doi: 10.1038/nri2803. Epub 2010 Jul 16. Review.

PMID:
20634814
4.

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems.

Stinchcombe JC, Salio M, Cerundolo V, Pende D, Arico M, Griffiths GM.

BMC Biol. 2011 Jun 28;9:45. doi: 10.1186/1741-7007-9-45.

5.

Actin depletion initiates events leading to granule secretion at the immunological synapse.

Ritter AT, Asano Y, Stinchcombe JC, Dieckmann NM, Chen BC, Gawden-Bone C, van Engelenburg S, Legant W, Gao L, Davidson MW, Betzig E, Lippincott-Schwartz J, Griffiths GM.

Immunity. 2015 May 19;42(5):864-76. doi: 10.1016/j.immuni.2015.04.013.

6.

Role of centrosome in regulating immune response.

Kumar A, Rajendran V, Sethumadhavan R, Purohit R.

Curr Drug Targets. 2014 May;15(5):558-63. Review.

PMID:
24655141
7.

UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion.

Iizuka Y, Cichocki F, Sieben A, Sforza F, Karim R, Coughlin K, Isaksson Vogel R, Gavioli R, McCullar V, Lenvik T, Lee M, Miller J, Bazzaro M.

J Immunol. 2015 Nov 15;195(10):4760-70. doi: 10.4049/jimmunol.1500979. Epub 2015 Oct 5.

8.

Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity.

Chemin K, Bohineust A, Dogniaux S, Tourret M, Guégan S, Miro F, Hivroz C.

J Immunol. 2012 Sep 1;189(5):2159-68. doi: 10.4049/jimmunol.1200156. Epub 2012 Jul 20.

9.

Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4.

Ménager MM, Ménasché G, Romao M, Knapnougel P, Ho CH, Garfa M, Raposo G, Feldmann J, Fischer A, de Saint Basile G.

Nat Immunol. 2007 Mar;8(3):257-67. Epub 2007 Jan 21.

PMID:
17237785
10.

Natural killer cell cytotoxicity: how do they pull the trigger?

Topham NJ, Hewitt EW.

Immunology. 2009 Sep;128(1):7-15. doi: 10.1111/j.1365-2567.2009.03123.x. Review.

11.

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.

Choudhuri K, Llodrá J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML.

Nature. 2014 Mar 6;507(7490):118-23. doi: 10.1038/nature12951. Epub 2014 Feb 2.

12.

New lamp posts allow for new views of the immunological synapse.

Raju S, Shaw AS.

Immunity. 2015 May 19;42(5):781-3. doi: 10.1016/j.immuni.2015.05.008.

13.

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.

Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM.

Elife. 2014 Mar 4;3:e01310. doi: 10.7554/eLife.01310.

14.

NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence.

Mace EM, Wu WW, Ho T, Mann SS, Hsu HT, Orange JS.

J Immunol. 2012 Nov 15;189(10):4870-80. doi: 10.4049/jimmunol.1201296. Epub 2012 Oct 12.

15.

An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse.

Bertrand F, Müller S, Roh KH, Laurent C, Dupré L, Valitutti S.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6073-8. doi: 10.1073/pnas.1218640110. Epub 2013 Mar 27.

16.

Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis.

Stinchcombe JC, Randzavola LO, Angus KL, Mantell JM, Verkade P, Griffiths GM.

Curr Biol. 2015 Dec 21;25(24):3239-44. doi: 10.1016/j.cub.2015.10.028. Epub 2015 Dec 5.

17.

The immunological synapse: a focal point for endocytosis and exocytosis.

Griffiths GM, Tsun A, Stinchcombe JC.

J Cell Biol. 2010 May 3;189(3):399-406. doi: 10.1083/jcb.201002027. Review.

18.

A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion.

Ménasché G, Ménager MM, Lefebvre JM, Deutsch E, Athman R, Lambert N, Mahlaoui N, Court M, Garin J, Fischer A, de Saint Basile G.

Blood. 2008 Dec 15;112(13):5052-62. doi: 10.1182/blood-2008-02-141069. Epub 2008 Sep 23.

19.

Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse.

Rak GD, Mace EM, Banerjee PP, Svitkina T, Orange JS.

PLoS Biol. 2011 Sep;9(9):e1001151. doi: 10.1371/journal.pbio.1001151. Epub 2011 Sep 13.

20.

Communication, the centrosome and the immunological synapse.

Stinchcombe JC, Griffiths GM.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130463. doi: 10.1098/rstb.2013.0463. Review.

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