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Items: 1 to 20 of 130

1.

Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.

Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH.

J Biol Chem. 2012 Nov 2;287(45):37868-79. doi: 10.1074/jbc.M112.398750.

2.

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

Thastrup JO, Rafiqi FH, Vitari AC, Pozo-Guisado E, Deak M, Mehellou Y, Alessi DR.

Biochem J. 2012 Jan 1;441(1):325-37. doi: 10.1042/BJ20111879.

3.

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR.

Biochem J. 2006 Jul 1;397(1):223-31.

4.

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.

J Biol Chem. 2005 Dec 30;280(52):42685-93.

5.

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T.

Biochem J. 2013 Apr 1;451(1):111-22. doi: 10.1042/BJ20121903.

6.

SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.

Grimm PR, Taneja TK, Liu J, Coleman R, Chen YY, Delpire E, Wade JB, Welling PA.

J Biol Chem. 2012 Nov 2;287(45):37673-90. doi: 10.1074/jbc.M112.402800.

7.

Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.

Sengupta S, Lorente-Rodríguez A, Earnest S, Stippec S, Guo X, Trudgian DC, Mirzaei H, Cobb MH.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18826-31. doi: 10.1073/pnas.1318676110.

8.

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.

Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10883-8.

9.
10.

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J.

Biochem J. 2014 Mar 15;458(3):559-73. doi: 10.1042/BJ20131478.

11.

Cotransporters, WNKs and hypertension: an update.

Flatman PW.

Curr Opin Nephrol Hypertens. 2008 Mar;17(2):186-92. doi: 10.1097/MNH.0b013e3282f5244e. Review.

PMID:
18277153
12.

WNK1 is required for mitosis and abscission.

Tu SW, Bugde A, Luby-Phelps K, Cobb MH.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1385-90. doi: 10.1073/pnas.1018567108.

13.
14.

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.

Richardson C, Sakamoto K, de los Heros P, Deak M, Campbell DG, Prescott AR, Alessi DR.

J Cell Sci. 2011 Mar 1;124(Pt 5):789-800. doi: 10.1242/jcs.077230.

15.

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT.

Sci Signal. 2014 Jul 15;7(334):re3. doi: 10.1126/scisignal.2005365. Review.

PMID:
25028718
16.

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.

Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR.

J Cell Sci. 2008 Mar 1;121(Pt 5):675-84. doi: 10.1242/jcs.025312.

17.

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S.

Clin Exp Nephrol. 2012 Aug;16(4):530-8.

PMID:
22294159
19.

Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.

Roy A, Goodman JH, Begum G, Donnelly BF, Pittman G, Weinman EJ, Sun D, Subramanya AR.

Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F366-76. doi: 10.1152/ajprenal.00612.2014.

20.
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