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Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells.

Clippinger AJ, Alwine JC.

Genes Dev. 2012 Sep 15;26(18):2015-26. doi: 10.1101/gad.196147.112.


Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation.

Clippinger AJ, Maguire TG, Alwine JC.

J Virol. 2011 Sep;85(18):9369-76. doi: 10.1128/JVI.05102-11. Epub 2011 Jul 6.


Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.

Bai Y, Xuan B, Liu H, Zhong J, Yu D, Qian Z.

J Virol. 2015 Aug;89(15):7625-35. doi: 10.1128/JVI.01027-15. Epub 2015 May 13.


The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection.

Clippinger AJ, Maguire TG, Alwine JC.

J Virol. 2011 Apr;85(8):3930-9. doi: 10.1128/JVI.01913-10. Epub 2011 Feb 9.


Amino acid regulation of TOR complex 1.

Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E592-602. doi: 10.1152/ajpendo.90645.2008. Epub 2008 Sep 2. Review.


Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication.

Moorman NJ, Shenk T.

J Virol. 2010 May;84(10):5260-9. doi: 10.1128/JVI.02733-09. Epub 2010 Feb 24.


Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.

Averous J, Lambert-Langlais S, Carraro V, Gourbeyre O, Parry L, B'Chir W, Muranishi Y, Jousse C, Bruhat A, Maurin AC, Proud CG, Fafournoux P.

Cell Signal. 2014 Sep;26(9):1918-27. doi: 10.1016/j.cellsig.2014.04.019. Epub 2014 May 2.


Human cytomegalovirus induces multiple means to combat reactive oxygen species.

Tilton C, Clippinger AJ, Maguire T, Alwine JC.

J Virol. 2011 Dec;85(23):12585-93. doi: 10.1128/JVI.05572-11. Epub 2011 Sep 21.


Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.

Groenewoud MJ, Goorden SM, Kassies J, Pellis-van Berkel W, Lamb RF, Elgersma Y, Zwartkruis FJ.

PLoS One. 2013 Nov 26;8(11):e81649. doi: 10.1371/journal.pone.0081649. eCollection 2013.


Key mediators of intracellular amino acids signaling to mTORC1 activation.

Duan Y, Li F, Tan K, Liu H, Li Y, Liu Y, Kong X, Tang Y, Wu G, Yin Y.

Amino Acids. 2015 May;47(5):857-67. doi: 10.1007/s00726-015-1937-x. Epub 2015 Feb 21. Review.


PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.

Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H.

J Biol Chem. 2014 Oct 24;289(43):29739-49. doi: 10.1074/jbc.M114.584821. Epub 2014 Aug 27.


The human cytomegalovirus protein pUL38 suppresses endoplasmic reticulum stress-mediated cell death independently of its ability to induce mTORC1 activation.

Qian Z, Xuan B, Gualberto N, Yu D.

J Virol. 2011 Sep;85(17):9103-13. doi: 10.1128/JVI.00572-11. Epub 2011 Jun 29. Erratum in: J Virol. 2011 Oct;85(20):10932.


MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.

Fawal MA, Brandt M, Djouder N.

Dev Cell. 2015 Apr 6;33(1):67-81. doi: 10.1016/j.devcel.2015.02.010. Epub 2015 Mar 26.


Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.

Wang X, Fonseca BD, Tang H, Liu R, Elia A, Clemens MJ, Bommer UA, Proud CG.

J Biol Chem. 2008 Nov 7;283(45):30482-92. doi: 10.1074/jbc.M803348200. Epub 2008 Aug 1.


Rheb and Rags come together at the lysosome to activate mTORC1.

Groenewoud MJ, Zwartkruis FJ.

Biochem Soc Trans. 2013 Aug;41(4):951-5. doi: 10.1042/BST20130037. Review.


Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.

Kudchodkar SB, Yu Y, Maguire TG, Alwine JC.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14182-7. Epub 2006 Sep 7.


Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids.

Zheng X, Liang Y, He Q, Yao R, Bao W, Bao L, Wang Y, Wang Z.

Int J Mol Sci. 2014 Nov 13;15(11):20753-69. doi: 10.3390/ijms151120753. Review.


Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.

Kimball SR, Ravi S, Gordon BS, Dennis MD, Jefferson LS.

J Nutr. 2015 Nov;145(11):2496-502. doi: 10.3945/jn.115.215491. Epub 2015 Sep 23.


MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer.

Chen MB, Wei MX, Han JY, Wu XY, Li C, Wang J, Shen W, Lu PH.

Cell Signal. 2014 Jan;26(1):102-9. doi: 10.1016/j.cellsig.2013.07.017. Epub 2013 Jul 27.


Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.

Wagner RJ, Martin KA, Powell RJ, Rzucidlo EM.

Am J Physiol Cell Physiol. 2010 Jul;299(1):C119-27. doi: 10.1152/ajpcell.00429.2009. Epub 2010 Apr 7.

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